Neuroplasticity-dependent and -independent mechanisms of chronic deep brain stimulation in stressed rats

Bambico, Francis Rodriguez; Bregman, Tatiana; Diwan, Mustansir; Li, J; Darvish-Ghane, Soroush; Li, Z; Laver, Bryce; Amorim, Beatriz Oliveira; Covolan, Luciene; Nóbrega, José N.; Hamani, Clement

doi:10.1038/tp.2015.166

Cited by 62 publications

(35 citation statements)

References 43 publications

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“…As such, axons from IL cells undergoing depolarization block, fibers en passant, and those innervating the stimulated target would still be responsive and may be activated at 130 Hz (Hamani et al, 2010). Under these circumstances, the net effect of IL DBS would correspond to that of an excitation, with IL projections being tonically driven and able to release neurotransmitters, increase BDNF levels, and enhance plasticity in downstream structures (eg, brainstem, amygdala, hippocampus) as well as in the target region (Bambico et al, 2015;Hamani et al, 2010).…”

Section: Prefrontal Cortexmentioning

confidence: 99%

Deep Brain Stimulation in Animal Models of Fear, Anxiety, and Posttraumatic Stress Disorder

Reznikov

Binko

Nóbrega

et al. 2016

Neuropsychopharmacol

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Although medications and psychotherapy are often effective for the treatment of posttraumatic stress disorder (PTSD), 20-30% of patients do not respond to these conventional therapies. In psychiatry, DBS has been either approved or is currently under investigation for different disorders. At present, whether DBS may be used to treat PTSD remains unknown. Preclinical research may provide the scientific rationale for helping conceive and further improve such trials. Some of the animal models commonly used to date are more suitable for investigating mechanisms of anxiety and fear than the long-lasting behavior that characterized PTSD. That said, mechanisms and neurocircuits involved in paradigms such as fear conditioning and extinction share several common features with those of PTSD. In this article, we review preclinical studies in which electrical stimulation has been delivered to animal models of PTSD-like behavior. In those studies, commonly targeted regions were the basolateral amygdala, ventral striatum, hippocampus, and prefrontal cortex. Overall, stimulation delivered at high frequencies to most of these targets improved fear extinction and anxiety-like behavior. Though further research is certainly needed, promising findings from DBS studies in animals are encouraging and suggest a positive future perspective for the field.

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Section: Prefrontal Cortexmentioning

confidence: 99%

Deep Brain Stimulation in Animal Models of Fear, Anxiety, and Posttraumatic Stress Disorder

Reznikov

Binko

Nóbrega

et al. 2016

Neuropsychopharmacol

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“…Beside changes in neurochemical and neurotrophin profiles, neuroplasticity changes induced by DBS have also been investigated. For instance, Bambico et al reported increased hippocampal neurogenesis and BDNF levels after vmPFC-DBS, which led to anti-anhedonic-like behaviors, but was not sufficient for an overall antidepressant-like effect [ 98 ]. Correspondingly, Liu et al found a correlation between vmPFC-HFS and hippocampal neurogenesis and improvements in short- and long-term memory in middle-aged rats.…”

Section: Preclinical Studies Of Electrical Stimulation In the Medimentioning

confidence: 99%

“…In contrast, Winter et al showed that 1 h of vmPFC-DBS with established DBS parameters in rodents did not increase the percentage of BrdU and Dcx double-stained cells in the dentate gyrus compared to the control [ 123 ]. Although research on the interaction between neurogenesis and substrates such as serotonin is ongoing, BDNF may be required to exert this antidepressant-like effect [ 98 ]. Neurogenesis is a widely investigated mechanism of DBS and these results indicate positive effects in the hippocampal region.…”

Section: Potential Mechanisms Of Stimulation-induced Antidepressanmentioning

confidence: 99%

“…The neurotrophin BDNF is important in synaptic regulation, neuronal survival, and differentiation of new neuron terminals in the adult brain [ 130 , 131 , 132 ]. Preclinical studies reported that depressive-like rats subjected to chronic unpredictable stress [ 92 , 98 ] or olfactory bulbectomy [ 33 ] had lower BDNF levels, whereas DBS increased BDNF levels, thus preventing the development of depressive-like behaviors. Extracellularly, pro-BDNF is cleaved by tissue plasminogen activator/plasmin to form mature BDNF.…”

Section: Potential Mechanisms Of Stimulation-induced Antidepressanmentioning

confidence: 99%

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A Decade of Progress in Deep Brain Stimulation of the Subcallosal Cingulate for the Treatment of Depression

Khairuddin

Ngo

Lim

et al. 2020

JCM

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Major depression contributes significantly to the global disability burden. Since the first clinical study of deep brain stimulation (DBS), over 446 patients with depression have now undergone this neuromodulation therapy, and 29 animal studies have investigated the efficacy of subgenual cingulate DBS for depression. In this review, we aim to provide a comprehensive overview of the progress of DBS of the subcallosal cingulate in humans and the medial prefrontal cortex, its rodent homolog. For preclinical animal studies, we discuss the various antidepressant-like behaviors induced by medial prefrontal cortex DBS and examine the possible mechanisms including neuroplasticity-dependent/independent cellular and molecular changes. Interestingly, the response rate of subcallosal cingulate Deep brain stimulation marks a milestone in the treatment of depression. DBS achieved response and remission rates of 64–76% and 37–63%, respectively, from clinical studies monitoring patients from 6–24 months. Although some studies showed its stimulation efficacy was limited, it still holds great promise as a therapy for patients with treatment-resistant depression. Overall, further research is still needed, including more credible clinical research, preclinical mechanistic studies, precise selection of patients, and customized electrical stimulation paradigms.

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“…This has been primarily evaluated in the hippocampus with more limited evaluation of the SVZ and RMS. Stimulation of the anterior thalamus ( Hamani et al, 2011 ), nucleus accumbens ( Schmuckermair et al, 2013 ), ventromedial PFC ( Bambico et al, 2015 ), entorhinal cortex ( Stone et al, 2011 ), and medial septum ( Jeong et al, 2014 ) have all been demonstrated to increase neurogenesis. Importantly neurogenesis has also been demonstrated in humans.…”

Section: Regenerative Aspects Of Nbm Dbsmentioning

confidence: 99%

Nucleus Basalis of Meynert Stimulation for Dementia: Theoretical and Technical Considerations

et al. 2018

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Deep brain stimulation (DBS) of nucleus basalis of Meynert (NBM) is currently being evaluated as a potential therapy to improve memory and overall cognitive function in dementia. Although, the animal literature has demonstrated robust improvement in cognitive functions, phase 1 trial results in humans have not been as clear-cut. We hypothesize that this may reflect differences in electrode location within the NBM, type and timing of stimulation, and the lack of a biomarker for determining the stimulation’s effectiveness in real time. In this article, we propose a methodology to address these issues in an effort to effectively interface with this powerful cognitive nucleus for the treatment of dementia. Specifically, we propose the use of diffusion tensor imaging to identify the nucleus and its tracts, quantitative electroencephalography (QEEG) to identify the physiologic response to stimulation during programming, and investigation of stimulation parameters that incorporate the phase locking and cross frequency coupling of gamma and slower oscillations characteristic of the NBM’s innate physiology. We propose that modulating the baseline gamma burst stimulation frequency, specifically with a slower rhythm such as theta or delta will pose more effective coupling between NBM and different cortical regions involved in many learning processes.

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Neuroplasticity-dependent and -independent mechanisms of chronic deep brain stimulation in stressed rats

Cited by 62 publications

References 43 publications

Deep Brain Stimulation in Animal Models of Fear, Anxiety, and Posttraumatic Stress Disorder

Deep Brain Stimulation in Animal Models of Fear, Anxiety, and Posttraumatic Stress Disorder

A Decade of Progress in Deep Brain Stimulation of the Subcallosal Cingulate for the Treatment of Depression

Nucleus Basalis of Meynert Stimulation for Dementia: Theoretical and Technical Considerations

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