Neuroplasticity Following Stroke from a Functional Laterality Perspective: A fNIRS Study

Song, Ying; Sun, ZhiFang; Wei⁃zhen, SUN; Luo, MeiLing; Du, YiJun; Jing, Jing; Wang, Yonghui

doi:10.1007/s10548-023-00946-z

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…Baskett et al (1996) noted sensorimotor impairments on the unaffected side in patients with right-lesion strokes, indicating compensatory adaptations associated with S1–M1 coupling in the affected hemisphere—observations that are consistent with our own findings [ 48 ]. In addition, Ying et al (2023) observed a negative correlation between motor function and the resting-state functional connectivity strength of the left S1 and M1 [ 49 ], further supporting the notion that improved motor function corresponds with reduced dependence on these brain areas. These examples highlighted the complex neural adaptations during stroke recovery, where decreased activation in specific regions indicated effective adaptation and rehabilitation.…”

Section: Discussionmentioning

confidence: 88%

Use of cortical hemodynamic responses in digital therapeutics for upper limb rehabilitation in patients with stroke

Kim,

Lee

et al. 2024

J NeuroEngineering Rehabil

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Background Stroke causes long-term disabilities, highlighting the need for innovative rehabilitation strategies for reducing residual impairments. This study explored the potential of functional near-infrared spectroscopy (fNIRS) for monitoring cortical activation during rehabilitation using digital therapeutics. Methods This cross-sectional study included 18 patients with chronic stroke, of whom 13 were men. The mean age of the patients was 67.0 ± 7.1 years. Motor function was evaluated through various tests, including the Fugl–Meyer assessment for upper extremity (FMA-UE), grip and pinch strength test, and box and block test. All the patients completed the digital rehabilitation program (MotoCog®, Cybermedic Co., Ltd., Republic of Korea) while being monitored using fNIRS (NIRScout®, NIRx Inc., Germany). Statistical parametric mapping (SPM) was employed to analyze the cortical activation patterns from the fNIRS data. Furthermore, the K-nearest neighbor (K-NN) algorithm was used to analyze task performance and fNIRS data to classify the severity of motor impairment. Results The participants showed diverse task performances in the digital rehabilitation program, demonstrating distinct patterns of cortical activation that correlated with different motor function levels. Significant activation was observed in the ipsilesional primary motor area (M1), primary somatosensory area (S1), and contralateral prefrontal cortex. The activation patterns varied according to the FMA-UE scores. Positive correlations were observed between the FMA-UE scores and SPM t-values in the ipsilesional M1, whereas negative correlations were observed in the ipsilesional S1, frontal lobe, and parietal lobe. The incorporation of cortical hemodynamic responses with task scores in a digital rehabilitation program substantially improves the accuracy of the K-NN algorithm in classifying upper limb functional levels in patients with stroke. The accuracy for tasks, such as the gas stove-operation task, increased from 44.4% using only task scores to 83.3% when these scores were combined with oxy-Hb t-values from the ipsilesional M1. Conclusions The results advocated the development of tailored digital rehabilitation strategies by combining the behavioral and cerebral hemodynamic data of patients with stroke. This approach aligns with the evolving paradigm of personalized rehabilitation in stroke recovery, highlighting the need for further extensive research to optimize rehabilitation outcomes.

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Section: Discussionmentioning

confidence: 88%

Use of cortical hemodynamic responses in digital therapeutics for upper limb rehabilitation in patients with stroke

Kim,

Lee

et al. 2024

J NeuroEngineering Rehabil

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“…Tras la repetición de una tarea motora específica se activan estructuras subcorticales que consiguen la mejora del movimiento y de la realización de la misma. Por lo que el aprendizaje motor implica cambios en la neuroplasticidad tanto a nivel cortical como subcortical que dependen del entrenamiento en la rehabilitación [210,211]. Así mismo, el aprendizaje motor interactúa con otros procesos además de los motores, como los cognitivos, sensoriales, perceptivo y/o emocionales.…”

Section: Neurorehabilitación Del Paciente Post-ictusunclassified

Efectos de la Terapia en Espejo vs. Ejercicio Terapéutico Cognoscitivo en la mejora de las funciones del miembro superior en pacientes con ictus

Fernández Solana

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Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery

Zich,

Ward,

Forss

et al. 2024

Preprint

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Improving outcomes after stroke depends on understanding both the causes of initial function/impairment and the mechanisms of recovery. Recovery in patients with initially low function/high impairment is variable, suggesting the factors relating to initial function/impairment are different to the factors important for subsequent recovery. Here we aimed to determine the contribution of altered brain structure and function to initial severity and subsequent recovery of the upper limb post-stroke. The Nine-Hole Peg Test was recorded in week 1 and one-month post-stroke and used to divide 36 stroke patients (18 females, age: M = 66.56 years) into those with high/low initial function and high/low subsequent recovery. We determined differences in week 1 brain structure (Magnetic Resonance Imaging) and function (Magnetoencephalography, tactile stimulation) between high/low patients for both initial function and subsequent recovery. Lastly, we examined the relative contribution of changes in brain structure and function to recovery in patients with low levels of initial function. Low initial function and low subsequent recovery are related to lower sensorimotor β power and greater lesion-induced disconnection of contralateral [ipsilesional] white-matter motor projection connections. Moreover, differences in intra-hemispheric connectivity (structural and functional) are unique to initial motor function, while differences in inter-hemispheric connectivity (structural and functional) are unique to subsequent motor recovery. Function-related and recovery-related differences in brain function and structure after stroke are related, yet not identical. Separating out the factors that contribute to each process is key to identifying potential therapeutic targets for improving outcomes.

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Neuroplasticity Following Stroke from a Functional Laterality Perspective: A fNIRS Study

Cited by 4 publications

References 46 publications

Use of cortical hemodynamic responses in digital therapeutics for upper limb rehabilitation in patients with stroke

Use of cortical hemodynamic responses in digital therapeutics for upper limb rehabilitation in patients with stroke

Efectos de la Terapia en Espejo vs. Ejercicio Terapéutico Cognoscitivo en la mejora de las funciones del miembro superior en pacientes con ictus

Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery

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