Neuroprotectin D1 Reduces the Severity of Herpes Simplex Virus–Induced Corneal Immunopathology

Rajasagi, Naveen K.; Reddy, Pradeep B. J.; Mulik, Sachin; Gjörstrup, P.; Rouse, Barry T.

doi:10.1167/iovs.13-12152

Cited by 53 publications

(46 citation statements)

References 36 publications

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“…RvE1 and PD1 are each potent and topically active in this infectious mouse model, reducing pro-inflammatory mediators and stimulating IL-10 66,67 . H5N1 virus lethal dissemination activates genes in mice tracked to LX biosynthesis, where sustained inflammation inhibits LX-mediated anti-inflammatory host responses, permitting viral dissemination 68 .…”

Section: Cellular Events In Resolution Of Acute Inflammationmentioning

confidence: 93%

“…Exogenous LXA 4 , RvE1 and PD1 each upregulate CCR5 expression on leukocytes that bind chemokines, facilitating their clearance and resolution 90 . Exogenous PD1 reduces CD4 + T cell infiltration into cornea 66 , as does RvE1 in Herpes simplex viral infections 67 . Exogenous RvD1 reduces CD11b + leukocytes and CD4 + and CD8 + T lymphocytes within the eye in uveitis 91 .…”

Section: Cellular Events In Resolution Of Acute Inflammationmentioning

confidence: 97%

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Pro-resolving lipid mediators are leads for resolution physiology

Serhan

2014

Nature

2,430

2,862

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Preface Advances on mechanisms in resolution of acute inflammation uncovered a new genus of pro-resolving lipid mediators that include separate families of molecules: lipoxins, resolvins, protectins and maresins, collectively coined specialized pro-resolving mediators (SPM). Synthetic SPM possess potent bioactions when administered in vivo. In animal experiments, SPM evoke anti-inflammatory and novel pro-resolving mechanisms as well as enhance microbial clearance. While identified in inflammation-resolution, SPM are conserved structures with functions also in host defense, pain, organ protection and tissue remodeling. This review covers SPM mechanisms and new omega-3 essential fatty acid pathways that open a path for physiologic functions.

show abstract

Section: Cellular Events In Resolution Of Acute Inflammationmentioning

confidence: 93%

Section: Cellular Events In Resolution Of Acute Inflammationmentioning

confidence: 97%

Pro-resolving lipid mediators are leads for resolution physiology

Serhan

2014

Nature

2,430

2,862

View full text Add to dashboard Cite

show abstract

“…RvE1 and PD1 are each potent and topically active in this infectious mouse model, reducing pro-inflammatory mediators and stimulating IL-10 [75, 76]. H5N1 virus lethal dissemination activates genes in mice tracked to LX biosynthesis, where sustained inflammation inhibits LX-mediated anti-inflammatory host responses that permit viral dissemination [77].…”

Section: Infectious Exudates and Resolution Programs In Host Defensementioning

confidence: 99%

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

Serhan¹,

Chiang²,

Dalli³

2015

Seminars in Immunology

479

412

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Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro-resolving mediators (SPM) including lipoxins, resolvins, protectins and maresins that are each temporally produced by resolving-exudates with distinct actions for return to homeostasis. SPM evoke potent anti-inflammatory and novel pro-resolving mechanisms as well as enhance microbial clearance. While born in inflammation-resolution, SPM are conserved structures with functions discovered in microbial defense, pain, organ protection and tissue regeneration, wound healing, cancer, reproduction, and neurobiology-cognition. This review covers these SPM mechanisms and other new omega-3 PUFA pathways that open their path for functions in resolution physiology.

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“…NPD1 is an endogenously produced lipid mediator that acts 1) to improve corneal nerve regeneration and 2) as an anti-inflammatory molecule [20,21]. For example, rabbits with experimental stromal defects treated with NPD1 showed enhanced neurite outgrowth, corneal sensitivity, and tear production, along with decreased neutrophil infiltration compared to controls [19].…”

Section: Neuroprotectinmentioning

confidence: 99%