Neuroprotection and enhanced neurogenesis by extract from the tropical plant Knema laurina after inflammatory damage in living brain tissue

Häke, Ines; Schönenberger, Silvia; Neumann, Jens; Franke, Katrin; Paulsen-Merker, K; Reymann, Klaus G.; Ismail, Ghazally; Din, Laily B.; Said, Ikram M.; Latiff, A.; Wessjohann, Ludger A.; Zipp, Frauke; Ullrich, Oliver

doi:10.1016/j.jneuroim.2008.10.007

Cited by 19 publications

(25 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, Moon et al [37] observed that an aqueous extract of Benincasa hispida Cogniaux reduced NF-jB promoter activity in glucose-induced vascular inflammation of human umbilical vein endothelial cells. The extract of the tropical plant Knema laurina (Myristicaceae) was used for centuries for the treatment of digestive and inflammatory diseases and inhibited NF-jB-translocation in brain tissue after inflammatory damage [21]. Lampronti et al [30] evaluated the inhibitory effects of Bangladeshi medicinal plant extracts on interactions between selected transcription factors and target DNA sequences and discovered that extracts from Terminalia arjuna and Saraca asoka appeared to be most efficient in inhibiting NF-jB binding activities.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf extract are mediated via modulation of the nuclear factor-κB pathway

et al. 2010

View full text Add to dashboard Cite

Azadirachta indica (neem tree) is used in traditional Indian medicine for its pharmacological properties including cancer prevention and treatment. Here, we studied a neem extract's anti-inflammatory potential via the nuclear factor-jB (NF-jB) signaling pathway, linked to cancer, inflammation, and apoptosis. Cultured human leukemia cells were treated with a methanolic neem leaf extract with or without tumor necrosis factor (TNF)-a stimulation. Inhibition of NF-jB activity was demonstrated by luciferase assay and electrophoretic mobility shift assay (EMSA). Inhibition of viability by neem extracts was assessed by luminescent assays. Western blot analysis allowed assessing the inhibitory effect of the neem extract on TNF-a-induced degradation of inhibitor of jB (IjB) and nuclear translocation of the NF-jB p50/p65 heterodimer. Inhibition of IjB kinase (IKK) activity was shown as well as the effect of neem extract on the induction of apoptotic cell death mechanisms by nuclear fragmentation analysis and flow cytometry analysis. In conclusion, our data provide evidence for a strong effect of the neem extract on proinflammatory cell signaling and apoptotic cell death mechanisms, contributing to a better understanding of the mechanisms triggered by Azadirachta indica.

show abstract

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf extract are mediated via modulation of the nuclear factor-κB pathway

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Over the years, Curcumin [1, 7-bis(4-hydroxy-3methoxyphenyl)-1, 6-heptadiene-3, 5-dione] has emerged as a multifunctional phytochemical with antioxidant, anti-inflammatory, anticancer, and neuroprotective properties [1–5]. However, in neurodegenerative diseases like Alzheimer's disease (AD) the molecular mechanism of action of Curcumin is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation

Banerjee

2014

Bioinorganic Chemistry and Applications

View full text Add to dashboard Cite

Mononuclear complexes of Curcumin with Cu(II) and Zn(II) have been synthesized and, characterized and their effects on the fibrillization and aggregation of amyloid-beta (Aβ) peptide have been studied. FTIR spectroscopy and atomic force microscopy (AFM) observations demonstrate that the complexes can inhibit the transition from less structured oligomers to β-sheet rich protofibrils which act as seeding factors for further fibrillization. The metal complexes also impart more improved inhibitory effects than Curcumin on peptide fibrillization.

show abstract

“…In this section, we calculate the equilibrium points of the system (11)- (16) and determine the parameter conditions for the existence of the different types of biological states. We find the steady-state solutions as follows:…”

Section: Equilibrium Pointsmentioning

confidence: 99%

“…The proof is clearly found from the steady states imposing (M 0 ; M 1 ; M 2 ; N SC ; D; C) > 0. Thus the models (11)- (16) obtain three points of equilibrium in the recovery stage by using MATHEMATICA.…”

Section: Equilibrium Pointsmentioning

confidence: 99%

“…This reaction is important in removing damaged cells from the brain tissue; however, it can also increase the harm to brain cells by producing free radicals that are toxic to healthy cells [2,14,15]. There has been an increasing amount of evidence suggesting that ischemic inflammation may be vital to the issue of pathogens, as ischemic stroke results not only in damage and neuronal loss but also in sustained neuroinflammation after stroke [3,16,17]. Microglial cells have been shown to take part in the neural analysis associated with adult brain function responsible for the harm occurring in the brain when a stroke occurs [3].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dynamic Modelling of Interactions between Microglia and Endogenous Neural Stem Cells in the Brain during a Stroke

2020

View full text Add to dashboard Cite

In this paper, we study the interactions between microglia and neural stem cells and the impact of these interactions on the brain cells during a stroke. Microglia cells, neural stem cells, the damage on brain cells from the stroke and the impacts these interactions have on living brain cells are considered in the design of mathematical models. The models consist of ordinary differential equations describing the effects of microglia on brain cells and the interactions between microglia and neural stem cells in the case of a stroke. Variables considered include: resident microglia, classically activated microglia, alternatively activated microglia, neural stem cells, tissue damage on cells in the brain, and the impacts these interactions have on living brain cells. The first model describes what happens in the brain at the stroke onset during the first three days without the generation of any neural stem cells. The second model studies the dynamic effect of microglia and neural stem cells on the brain cells following the generation of neural stem cells and potential recovery after this stage. We look at the stability and the instability of the models which are both studied analytically. The results show that the immune cells can help the brain by cleaning dead cells and stimulating the generation of neural stem cells; however, excessive activation may cause damage and affect the injured region. Microglia have beneficial and harmful functions after ischemic stroke. The microglia stimulate neural stem cells to generate new cells that substitute dead cells during the recovery stage but sometimes the endogenous neural stem cells are highly sensitive to inflammatory in the brain.

show abstract

Neuroprotection and enhanced neurogenesis by extract from the tropical plant Knema laurina after inflammatory damage in living brain tissue

Cited by 19 publications

References 40 publications

Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf extract are mediated via modulation of the nuclear factor-κB pathway

Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf extract are mediated via modulation of the nuclear factor-κB pathway

Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation

Dynamic Modelling of Interactions between Microglia and Endogenous Neural Stem Cells in the Brain during a Stroke

Contact Info

Product

Resources

About