Neuroprotection by curcumin: A review on brain delivery strategies

Askarizadeh, Anis; Barreto, George E.; Henney, Neil C.; Majeed, Muhammed; Sahebkar, Amirhossein

doi:10.1016/j.ijpharm.2020.119476

Cited by 74 publications

(32 citation statements)

References 158 publications

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“…These authors demonstrated that purified curcumin crosses the BBB at lower concentrations than when transported by nanoparticles. Technologies that facilitate the transport of curcumin to the brain, including nanocarriers and polymeric nanoparticles, are currently under investigation ( Tsai et al, 2011 ; Askarizadeh et al, 2020 ). Given this, one of the limitations of the present study is the lack of the definition of the amount of curcumin that crossed the BBB.…”

Section: Discussionmentioning

confidence: 99%

A Combination of Curcuma longa and Diazepam Attenuates Seizures and Subsequent Hippocampal Neurodegeneration

Nascimento

Ferreira

Silva

et al. 2022

Front. Cell. Neurosci.

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Epilepsy is one of the most common neurological disorders, which occurs due to the instability in the inhibitory and excitatory synaptic transmissions in the brain. However, many patients develop resistance to the available drugs, which results in cell degeneration caused due to inadequate control of the seizures. Curcumin, Curcuma longa, is known to be effective for the treatment of organic disorders and may prevent seizures, reduce oxidative stress, and decrease brain damage. Given this, the present study evaluated the antiepileptic effects of C. longa in comparison with both the diazepam and the combined application of these two substances, in terms of their effects on the brain activity and the potential histopathological changes in the hippocampus. This study used male Wistar rats (age: 10–12 weeks; weight: 260 ± 20 g), which were pretreated for 4 days with either saline, C. longa, diazepam, or C. longa + diazepam; and on the fifth day, pentylenetetrazol (PTZ) was administered to induce the seizure. In the C. longa group, a significant increase was observed in the latency of the onset of seizure-related behavior. Surprisingly, however, the combined treatment resulted in the best control of the seizure-related behavior, with the greatest latency of the onset of spasms and isolated clonic seizures. This group also obtained the best results in the electroencephalographic trace and seizure control, with a reduction in the frequency and amplitude of the spike-waves. In the saline group, PTZ significantly reduced the number of cells present in the CA1 and CA3 regions of the hippocampus, while the combined treatment obtained the best results in terms of the preservation of the neuron-like cells. These findings indicate that C. longa may contribute to the control of both seizures and the cell damage induced by PTZ, and that its association with diazepam may be a potentially effective option for the treatment of epilepsy in the future.

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Section: Discussionmentioning

confidence: 99%

A Combination of Curcuma longa and Diazepam Attenuates Seizures and Subsequent Hippocampal Neurodegeneration

Nascimento

Ferreira

Silva

et al. 2022

Front. Cell. Neurosci.

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“…Moreover, when it comes to future treatment THAT the blood-brain barrier (BBB) still represents the major obstacle when it comes to the delivery of pharmacological substances into the brain parenchyma and its neural cells. L48H37 is an analog of curcumin, a hydrophobic polyphenol extracted from the dried rhizomes of Curcuma longa, with limited BBB penetrance, promising approaches via nano delivery of curcumin were recently reported to improve drug delivery ( Askarizadeh et al, 2020 ; Motavaf et al, 2020 ). C20, on the other hand, as a chalcone derivate of flavonoids/isoflavonoids, is of small molecular size and its lipophilicity suggests a great BBB permeability ( Thapa et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits

Göttle

Schichel

Reiche

et al. 2021

Front. Cell. Neurosci.

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Myelin repair in the adult central nervous system (CNS) is driven by successful differentiation of resident oligodendroglial precursor cells (OPCs) and thus constitutes a neurodegenerative process capable to compensate for functional deficits upon loss of oligodendrocytes and myelin sheaths as it is observed in multiple sclerosis (MS). The human endogenous retrovirus type W (HERV-W) represents an MS-specific pathogenic entity, and its envelope (ENV) protein was previously identified as a negative regulator of OPC maturation—hence, it is of relevance in the context of diminished myelin repair. We here focused on the activity of the ENV protein and investigated how it can be neutralized for improved remyelination. ENV-mediated activation of toll like receptor 4 (TLR4) increases inducible nitric oxide synthase (iNOS) expression, prompts nitrosative stress, and results in myelin-associated deficits, such as decreased levels of oligodendroglial maturation marker expression and morphological alterations. The intervention of TLR4 surface expression represents a potential means to rescue such ENV-dependent deficits. To this end, the rescue capacity of specific substances, either modulating V-ATPase activity or myeloid differentiation 2 (MD2)-mediated TLR4 glycosylation status, such as compound 20 (C20), L48H437, or folimycin, was analyzed, as these processes were demonstrated to be relevant for TLR4 surface expression. We found that pharmacological treatment can rescue the maturation arrest of oligodendroglial cells and their myelination capacity and can prevent iNOS induction in the presence of the ENV protein. In addition, downregulation of TLR4 surface expression was observed. Furthermore, mitochondrial integrity crucial for oligodendroglial cell differentiation was affected in the presence of ENV and ameliorated upon pharmacological treatment. Our study, therefore, provides novel insights into possible means to overcome myelination deficits associated with HERV-W ENV-mediated myelin deficits.

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“…Besides, curcumin that is encapsulated in PLGA based-nanoparticulate formulation has shown that formulated curcumin could activate Nrf2 in the presence of H 2 O 2 . Hence, it might be proper to protect neurons against Alzheimer's disease [83].…”

Section: Formulation and Functional Improvement Of Curcuminmentioning

confidence: 99%

Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications

Rahban

Rezaei

Mazaheri³

et al. 2020

Antioxidants

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Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential transcription factor that maintains the cell’s redox balance state and reduces inflammation in different adverse stresses. Under the oxidative stress, Nrf2 is separated from Kelch-like ECH-associated protein 1 (Keap1), which is a key sensor of oxidative stress, translocated to the nucleus, interacts with the antioxidant response element (ARE) in the target gene, and then activates the transcriptional pathway to ameliorate the cellular redox condition. Curcumin is a yellow polyphenolic curcuminoid from Curcuma longa (turmeric) that has revealed a broad spectrum of bioactivities, including antioxidant, anti-inflammatory, anti-tumor, and anti-viral activities. Curcumin significantly increases the nuclear expression levels and promotes the biological effects of Nrf2 via the interaction with Cys151 in Keap1, which makes it a marvelous therapeutic candidate against a broad range of oxidative stress-related diseases, including type 2 diabetes (T2D), neurodegenerative diseases (NDs), cardiovascular diseases (CVDs), cancers, viral infections, and more recently SARS-CoV-2. Currently, the multifactorial property of the diseases and lack of adequate medical treatment, especially in viral diseases, result in developing new strategies to finding potential drugs. Curcumin potentially opens up new views as possible Nrf2 activator. However, its low bioavailability that is due to low solubility and low stability in the physiological conditions is a significant challenge in the field of its efficient and effective utilization in medicinal purposes. In this review, we summarized recent studies on the potential effect of curcumin to activate Nrf2 as the design of potential drugs for a viral infection like SARS-Cov2 and acute and chronic inflammation diseases in order to improve the cells’ protection.

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Neuroprotection by curcumin: A review on brain delivery strategies

Cited by 74 publications

References 158 publications

A Combination of Curcuma longa and Diazepam Attenuates Seizures and Subsequent Hippocampal Neurodegeneration

A Combination of Curcuma longa and Diazepam Attenuates Seizures and Subsequent Hippocampal Neurodegeneration

TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits

Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications

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