Neuroprotection in Alzheimer Disease

Jain, Kewal K.

doi:10.1007/978-1-4939-9465-6_8

Cited by 3 publications

(4 citation statements)

References 145 publications

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“…Exosome releases increased intracellular calcium ( Ca 2+ ) (Jain, 2019 ). Specifically, Veletić et al ( 2019 ) have shown that depolarization of neurons and glial cells, such as astrocytes, can trigger multivesicular exosome release therefrom.…”

Section: Introductionmentioning

confidence: 99%

A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease

Shaheen

Singh

Melnik

2021

Front. Comput. Neurosci.

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Exosomes are nano-sized extracellular vesicles that perform a variety of biological functions linked to the pathogenesis of various neurodegenerative disorders. In Alzheimer's disease (AD), for examples, exosomes are responsible for the release of Aβ oligomers, and their extracellular accumulation, although the underpinning molecular machinery remains elusive. We propose a novel model for Alzheimer's Aβ accumulation based on Ca2+-dependent exosome release from astrocytes. Moreover, we exploit our model to assess how temperature dependence of exosome release could interact with Aβ neurotoxicity. We predict that voltage-gated Ca2+ channels (VGCCs) along with the transient-receptor potential M8 (TRPM8) channel are crucial molecular components in Alzheimer's progression.

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Section: Introductionmentioning

confidence: 99%

A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease

Shaheen

Singh

Melnik

2021

Front. Comput. Neurosci.

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“…Similarly, a model of diabetic nephropathy suggested that treatment with pioglitazone reduces glomerular sclerosis, fibrosis, and hypertrophy by lowering ICAM-1, E-selectin, and albuminuria [ 98 , 99 ]. However, a study on women with polycystic ovarian syndrome found that pioglitazone treatment for insulin resistance dramatically improved endothelial-independent function, adipokines, and ET-1 [ 100 ]. Furthermore, VIP modulation played a significant role in carbohydrate and lipid metabolism [ 101 ], in addition to being a potent anti-inflammatory and neuroendocrine vasodilator [ 102 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, in an STZ-induced diabetes mellitus rat model, pioglitazone administration for four weeks in a row restored ET-1, superoxide dehydrogenase (SOD), and NAD(P)H oxidase activity, thereby restoring aortic function [ 100 , 103 ]. Pitocco et al [ 104 ] reported pioglitazone’s effectiveness in treating pulmonary hypertension rats via inhibiting cellular remodeling, proliferation, and inflammation of VSMCs.…”

Section: Discussionmentioning

confidence: 99%

Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR Expression

et al. 2022

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Type 2 diabetes mellitus (T2D) is a world wild health care issue marked by insulin resistance, a risk factor for the metabolic disorder that exaggerates endothelial dysfunction, increasing the risk of cardiovascular complications. Peroxisome proliferator-activated receptor PPAR) agonists have therapeutically mitigated hyperlipidemia and hyperglycemia in T2D patients. Therefore, we aimed to experimentally investigate the efficacy of newly designed synthetic PPARα/Ƴ partial agonists on a High-Fat Diet (HFD)/streptozotocin (STZ)-induced T2D. Female Wistar rats (200 ± 25 g body weight) were divided into four groups. The experimental groups were fed the HFD for three consecutive weeks before STZ injection (45 mg/kg/i.p) to induce T2D. Standard reference PPARƳ agonist pioglitazone and the partial synthetic PPARƳ (PIO; 20 mg/kg/BW, orally) were administered orally for 2 weeks after 72 h of STZ injection. The aorta tissue was isolated for biological ELISA, qRT-PCR, and Western blotting investigations for vascular inflammatory endothelial mediators endothelin-1 (ET-1), intracellular adhesion molecule 1 (ICAM-1), E-selectin, and anti-inflammatory vasoactive intestinal polypeptide (VIP), as well as microRNA126-5p and p-AKT/p-Pi3k/p-PDK-1/p-mTOR, endothelial Nitric Oxide Synthase (eNOS) immunohistochemical staining all are coupled with and histopathological examination. Our results revealed that HFD/STZ-induced T2D increased fasting blood glucose, ET-1, ICAM-1, E-selectin, and VIP levels, while decreasing the expression of both microRNA126-5p and p-AKT/p-Pi3k/p-PDK-1/p-mTOR phosphorylation. In contrast, the partial synthetic PPARƳ derivative evidenced a vascular alteration significantly more than reference PIO via decreasing (ET-1), ICAM-1, E-selectin, and VIP, along with increased expression of microRNA126-5p and p-AKT/p-Pi3k/p-PDK-1/p-mTOR. In conclusion, the partial synthetic PPARƳ derivative significantly affected HFD/STZ-induced T2D with vascular complications in the rat aorta.

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“…Selenium is also known as a "doubleedged element", because it has a very narrow threshold between nutritional deficiencies (40 µg/d) and toxic levels (400 µg/d) [1]. Total dissolved selenium (TDSe) in natural water exhibits complex behavior as it exists in multiple oxidation states (-II, IV, and VI) and participates in a variety of complex biogeochemical cycling processes [2][3][4][5]. Selenium has antioxidant, anticancer and antagonistic effects against heavy metals.…”

Section: Introductionmentioning

confidence: 99%

Field Determination and Spatial Distribution of Se (IV) in Coastal Seawater of China

Liu,

Pan,

Wei

et al. 2024

JMSE

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A portable electrochemical system based on rGO/AuNPs/Nafion was constructed for selenium (IV) field determination in coastal seawater of the North Yellow Sea, East China Sea and South China Sea. This system demonstrated a low determination limit (0.03 μg/L), a wide linear range of concentration (0.1–30 μg/L), exceptional reproducibility and repeatability, and excellent selectivity. Each individual, entire test could be accomplished within 8 min. In Yantai Sishili Bay, the Se (IV) concentrations ranged from 0.16–3.59 μg/L (average 1.43 μg/L). In Shengshan Island, the Se (IV) concentrations ranged from 0.20–5.18 μg/L (average 2.06 μg/L). In Zhelin Bay, the Se (IV) concentrations ranged from 0.87–4.87 μg/L (average 3.13 μg/L). The average concentrations of Se (IV) in surface seawater showcased an increasing trend from the north to the south of China, suggesting Zhelin Bay > Shengshan Island > Sishili Bay. The system develops a new, competitive method for water quality assessment, and contributes to the accurate study of the biogeochemical cycles of selenium.

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Neuroprotection in Alzheimer Disease

Cited by 3 publications

References 145 publications

A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease

A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease

Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR Expression

Field Determination and Spatial Distribution of Se (IV) in Coastal Seawater of China

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