Neuroprotection in Cerebrovascular Disease

Sildenafil Versus Aspirin with Intrauterine Growth Restriction

“…8 Grounded on this supposition, some researches have established that low dosage aspirin may correct the intra-vascular non-balance among PGI2 and TXA2, consequently avoiding or delaying the pathogenesis of the disorder . 9 Histologically, IUGR displays a similar faulty placentation as preeclampsia. Therefore, if low dosage aspirin prophylaxis against preeclampsia is operative it may avoid not only that disease but also some situations of IUGR by fluctuating the equilibrium to inhibitions of TXA2 synthesis and thus improve uteroplacental blood flowing .…”

Combined application of hypothermia and medical gases in cerebrovascular diseases

“…In this context, neuroprotective treatment has sprung up, and has achieve good results in basic research, becoming a new direction of stroke research. Neuroprotective treatment refers to the protection of brain parenchyma or brain cells, rather than revascularization, and can be used for the treatment of various cerebrovascular diseases 4. Currently, there are several kinds of mechanisms involved in neuroprotective therapy, including ion channel modulators,5 anti-excitotoxic drugs,6 free radical scavengers,7 neurotrophic factors,8 hypothermia therapy (HT),9 gene therapy and stem cell transplantation 10.…”

"Modulação térmica da lesão isquêmica: estudo in vitro"

“…Na verdade, estudos demonstram que a minoria dos sobreviventes, cerca de 3-10%, conseguem retornar às suas atividades normais e o grande número de incapacitados constitui custo elevado para os sistemas de saúde e de previdência social Jain, 2000;White et al, 2000).…”