Neuroprotection or neurotoxicity? new insights into the effects of Acanthopanax senticosus harms on nervous system through cerebral metabolomics analysis

Zhang, Shuai-nan; Li, Xu‐zhao; Wang, Yu; zhang, Na; Yang, Zhiming; liu, Shu-min; Lü, Fang

doi:10.1016/j.jep.2014.08.037

Cited by 32 publications

(18 citation statements)

References 35 publications

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“…The contents of eleutheroside B and eleutheroside E in AS were 7.63 70.34% (w/w) and 10.907 0.22% (w/w), respectively (Li et al, 2014a;Li et al, 2014b). The fingerprint analysis of the same batch of extract was also shown in our pre-studies (Li et al, 2014a;Li et al, 2014b;Zhang et al, 2014).…”

Section: Plant Materials and Extractionsupporting

confidence: 72%

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Cerebral potential biomarkers discovery and metabolic pathways analysis of α-synucleinopathies and the dual effects of Acanthopanax senticosus Harms on central nervous system through metabolomics analysis

Zhang

Lü

et al. 2015

Journal of Ethnopharmacology

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Section: Plant Materials and Extractionsupporting

confidence: 72%

Section: Plant Materials and Extractionmentioning

confidence: 99%

Cerebral potential biomarkers discovery and metabolic pathways analysis of α-synucleinopathies and the dual effects of Acanthopanax senticosus Harms on central nervous system through metabolomics analysis

Zhang

Lü

et al. 2015

Journal of Ethnopharmacology

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“…The yield of the extract is 1.3% (w/w). The fingerprint analysis of the same batch of extract was also shown in our previous studies (Li et al ., ; Li et al ., ; Zhang et al ., ).…”

Section: Methodsmentioning

confidence: 99%

“…The voucher specimen (hlj-201003) of the herb was authenticated by Professor Ke Fu, Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine. The preparation of extracts was shown in our previous studies (Li et al, 2013b;Li et al, 2014a;Li et al, 2014b;Liu et al, 2012;Zhang et al, 2014). Briefly, the crude drugs were extracted three times with 10 volume of 80% ethanol for 2h each and purified by AB-8 macroporous adsorption resin.…”

Section: Methodsmentioning

confidence: 99%

Microarray Expression Analysis for the Paradoxical Roles ofAcanthopanax senticosusHarms in Treating α-Synucleinopathies

Zhang

Lü

et al. 2015

Phytother. Res.

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α-Synuclein is a key player in the pathogenesis of neurodegenerative disorders with Lewy bodies. Our previous studies have also showed that Acanthopanax senticosus harms (AS) could significantly suppress α-synuclein overexpression and toxicity. Identifying the RNAs related to α-synucleinopathies may facilitate understanding the pathogenesis of the diseases and the safe application of AS in the clinic. Microarray expression profiling of long non-coding RNAs (lncRNAs) and mRNAs was undertaken in control non-transgenic and human α-synuclein transgenic mice. The effects of AS on central nervous system (CNS) in pathology and physiology were investigated based on the lncRNA/mRNA targets analysis. In total, 341 lncRNAs and 279 mRNAs were differentially expressed by α-synuclein stimulus, among which 29 lncRNAs and 25 mRNAs were involved in the anti-α-synucleinopathies mechanism of AS. However, the levels of 19/29 lncRNAs and 12/25 mRNAs in AS group were similar to those in α-synuclein group, which may cause potential neurotoxicity analogous to α-synuclein. This study demonstrated that some of lncRNAs/mRNAs were involved in α-synuclein related pathophysiology, and AS produced the bidirectional effects on CNS under pathological and physiological conditions.

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“…Metabonomics is a well-established method in systems biology, but it is still emerging for the study of herbal intervention [4,12,13]. Metabonomics provide a powerful platform for monitoring multiple endogenous metabolite levels simultaneously in the samples from cell lines [14], tissues [4], and body fluids [13,15].…”

Section: Asmentioning

confidence: 99%

Metabonomic Study of the Effects of Acanthopanax senticosus on Peripheral System of Rats

Zhang

Liu

et al. 2015

Planta Med

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Acanthopanax senticosus is extensively used to treat various nervous and cerebrovascular diseases in traditional medicinal systems in China and Russia. Ultrahigh-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry coupled with pattern recognition methods was used to investigate the effects of A. senticosus on the peripheral system in rats. The analysis of possible pathways influenced by A. senticosus was performed with MetaboAnalyst and Cytoscape software. After treatment with A. senticosus, 21 modulated metabolites in heart tissue, 20 in liver tissue, 14 in spleen tissue, 17 in lung tissue, 16 in kidney tissue, and 12 in a serum sample were identified and considered potential biomarkers of A. senticosus treatments. The regulation of some endogenous metabolites by A. senticosus could be beneficial for the treatment of several peripheral system diseases, such as hypertension, cancer, and oxidative stress, etc. However, there were also some upregulated endogenous metabolites producing potential toxicity to the peripheral system. A metabonomic analysis revealed that protection and toxicity coexisted in the effects of A. senticosus on the peripheral system, which may be a practical guide for its safe use and beneficial to the expansion of its application.

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Neuroprotection or neurotoxicity? new insights into the effects of Acanthopanax senticosus harms on nervous system through cerebral metabolomics analysis

Cited by 32 publications

References 35 publications

Cerebral potential biomarkers discovery and metabolic pathways analysis of α-synucleinopathies and the dual effects of Acanthopanax senticosus Harms on central nervous system through metabolomics analysis

Cerebral potential biomarkers discovery and metabolic pathways analysis of α-synucleinopathies and the dual effects of Acanthopanax senticosus Harms on central nervous system through metabolomics analysis

Microarray Expression Analysis for the Paradoxical Roles ofAcanthopanax senticosusHarms in Treating α-Synucleinopathies

Metabonomic Study of the Effects of Acanthopanax senticosus on Peripheral System of Rats

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