Neuroprotection Strategies During Cardiopulmonary Bypass

Ootaki, Yoshio; Ungerleider, Ross M.

doi:10.1007/978-1-4471-4619-3_76

Cited by 3 publications

(2 citation statements)

References 127 publications

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“…Previous studies also found the same results (21)(22)(23)(24). Some researchers also reported increased sodium levels after liver transplant is associated with postoperative complications (13)(14)(15)(16)(25)(26)(27)(28)(29).…”

Section: Discussionsupporting

confidence: 58%

Association of Perioperative Serum Sodium Level Fluctuation and Postoperative Complications in Coronary Artery Bypass Graft Surgery

Azarfarin

Shekoohi

Totonchi

et al. 2017

Multidiscip CardioAnnal

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Background: Electrolyte abnormalities are common in coronary artery bypass graft surgery (CABG) using cardiopulmonary bypass (CPB). Changes in serum sodium (Na) concentration more than 15 meq/L in perioperative period (Delta Na > 15) is considered as significant fluctuation. The aim of this study was evaluating the relationship between the significant fluctuation of serum Na level and the complications after coronary artery bypass graft surgery. Methods: In this prospective observational study 59 patients who were candidates for CABG with CPB were enrolled into the study. We recorded patients' demographic data, arterial blood gas analysis (ABG), serum electrolytes including Na levels from anesthesia induction, during and after CPB up to 24 hours after admission in ICU. Postoperative complications until discharge from ICU were compared between patients with significant Na fluctuation and those without it.Results: Thirty-nine patients had serum sodium fluctuation equal and more than 15 mEq/L (Delta Na ≥ 15 group). This group was compared with those who had minor Na variation (Delta Na < 15; n = 20). The Na > 15 mEq/L fluctuation group had higher serum Na and lactate levels, lower base excess in ABG. Patients with at least one postoperative complication, were older and had lower ejection fraction and more sodium fluctuations. Logistic regression analysis showed that serum sodium fluctuation more than 15mEq/l was independently associated with post CABG complications. Conclusions: Perioperative serum sodium fluctuation more than 15mEq/L was independently associated with postoperative complications in patients undergoing CABG.

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Section: Discussionsupporting

confidence: 58%

Association of Perioperative Serum Sodium Level Fluctuation and Postoperative Complications in Coronary Artery Bypass Graft Surgery

Azarfarin

Shekoohi

Totonchi

et al. 2017

Multidiscip CardioAnnal

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“…3 The arrested heart and the relative freedom from blood in the surgical environment are among the advantages of the CPB application. 4 On the other hand, it is a non-physiological process associated with many complications. Activating the inflammatory response and coagulation cascade due to blood contact with the artificial surfaces, lack of pulsatile flow may result in ischemic injury and prolonged recovery after heart surgery.…”

Section: Introductionmentioning

confidence: 99%

Pulsatile versus non-pulsatile perfusion in coronary artery bypass operation: The comparison of laboratory and clinical outcomes

et al. 2022

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Introduction The superiority of pulsatile or non-pulsatile perfusion in cardiopulmonary bypass (CPB) regarding morbidity and mortality is still debated. Therefore, we aimed to investigate the effect of different pulse rates in pulsatile perfusion in patients undergoing coronary artery bypass graft (CABG) and compared it with non-pulsatile perfusion. Materials and Methods In this randomized clinical trial, 90 patients who were all candidates for CABG under CPB were enrolled. Patients in groups A and B received pulsatile perfusion with 30 and 70 pulses per minute, and group C received non-pulsatile perfusion. The biochemical and clinical parameters in the ICU were evaluated in the study groups. Results There was no statistically significant difference between patients' clinical outcomes and kidney and liver function markers (all Ps> 0.05). Mean serum lactate level increased but did not show a statistically significant difference between the study groups ( p = 0.8). The mean urine volume at 12 and 24 h after surgery was higher in group A, but there was no statistically significant difference between the three groups during the study period ( p = 0.3). No significant difference was found in the length of the ICU stay between the study groups ( p = 0.2). Conclusion Our studied parameters demonstrated no significant difference between pulsatile and non-pulsatile and between 30 and 70 pulse rate pulsatile perfusion methods. Our findings support that pulsatile perfusion with different pulse rates has no advantages over non-pulsatile perfusion in selected CABG cases.

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Modified Ultrafiltration in Coronary Artery Bypass Grafting: A Randomized, Double-Blinded, Controlled Clinical Trial

Tabaei¹,

Mortazian²,

Yaghoubi³

et al. 2018

Iran Red Crescent Med J

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Neuroprotection Strategies During Cardiopulmonary Bypass

Cited by 3 publications

References 127 publications

Association of Perioperative Serum Sodium Level Fluctuation and Postoperative Complications in Coronary Artery Bypass Graft Surgery

Association of Perioperative Serum Sodium Level Fluctuation and Postoperative Complications in Coronary Artery Bypass Graft Surgery

Pulsatile versus non-pulsatile perfusion in coronary artery bypass operation: The comparison of laboratory and clinical outcomes

Modified Ultrafiltration in Coronary Artery Bypass Grafting: A Randomized, Double-Blinded, Controlled Clinical Trial

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