Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway

Frandsen, Joel; Narayanasamy, Prabagaran

doi:10.1016/j.redox.2017.10.015

Cited by 97 publications

(75 citation statements)

References 140 publications

(317 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, due to its beneficial effects on mitochondria, resveratrol was proposed as a promising nutraceutical supplement in the treatment of mitochondrial disorders (De Paepe , Van Coster, 2017). Also, due to its antioxidant properties, flavonoids have demonstrated neuroprotective actions against neurodegeneration (Frandsen , Narayanasamy, 2018). Equally, high dietary intake of carotenoids appears to reduce the risk of stroke and stroke mortality (Bahonar et al, 2017).…”

Section: Ros Mitochondrial Dna and Agingmentioning

confidence: 99%

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi

Marchi

Simões

et al. 2018

International Review of Cell and Molecular Biology

284

162

View full text Add to dashboard Cite

Aging has been linked to several degenerative processes that, through the accumulation of molecular and cellular damage, can progressively lead to cell dysfunction and organ failure. Human aging is linked with a higher risk for individuals to develop cancer, neurodegenerative, cardiovascular, and metabolic disorders. The understanding of the molecular basis of aging and associated diseases has been one major challenge of scientific research over the last decades. Mitochondria, the center of oxidative metabolism and principal site of reactive oxygen species (ROS) production, are crucial both in health and in pathogenesis of many diseases. Redox signaling is important for the modulation of cell functions and several studies indicate a dual role for ROS in cell physiology. In fact, high concentrations of ROS are pathogenic and can cause severe damage to cell and organelle membranes, DNA, and proteins. On the other hand, moderate amounts of ROS are essential for the maintenance of several biological processes, including gene expression. In this review, we provide an update regarding the key roles of ROS-mitochondria cross talk in different fundamental physiological or pathological situations accompanying aging and highlighting that mitochondrial ROS may be a decisive target in clinical practice.

show abstract

Section: Ros Mitochondrial Dna and Agingmentioning

confidence: 99%

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi

Marchi

Simões

et al. 2018

International Review of Cell and Molecular Biology

284

162

View full text Add to dashboard Cite

show abstract

“…Henceforth, CHE presents outstanding antioxidant quality, as the anodic peak occurred at 0.2 V, wherein higher reducing power at physiological pH is associated to peak potentials below 0.5 V [8, 9]. …”

Section: Resultsmentioning

confidence: 99%

“…This pattern implies that sample compounds may repeatedly undergo oxidation to restore endogenous antioxidants in physiological environment. Henceforth, the thermodynamic reducing feasibility and their reversible profile imply that CHE possesses noteworthy antioxidant properties [8, 9]. …”

Section: Resultsmentioning

confidence: 99%

“…Cagaita's main phytocompounds, quercetin and catechin, are known for their beneficial action in human health due to anticancer, neuroprotective, and anti-inflammatory activities. Moreover, these phytochemical markers allow sample redox reversibility through catechol/quinone conversion [8] and therefore further strengthen antioxidant activity [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant and Neuroprotective Properties of Eugenia dysenterica Leaves

Thomaz

Peixoto

Oliveira

et al. 2018

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Eugenia dysenterica ex DC Mart. (Myrtaceae), popularly known as “cagaita,” is a Brazilian plant rich in polyphenols and other antioxidant compounds. Aiming to evaluate the potential use of cagaita in pathologies involving oxidative stress, such as neurodegenerative disorders, this study investigated its antioxidant potential and neuroprotective effect. Electrochemical approaches and aluminium-induced neurotoxicity were used to determine respectively in vitro and in vivo antioxidant properties of cagaita. Voltammetric experiments were carried out in a three-electrode system, whose working electrode consisted of glassy carbon. Male Swiss mice were administered with AlCl3 orally at a dose of 100 mg/kg/day and with cagaita leaf hydroalcoholic extract (CHE) at doses of 10, 100, and 300 mg/kg/day. The redox behavior of CHE presented similar features to that of quercetin, a widely known antioxidant standard. CHE prevented mouse memory impairment which resulted from aluminium intake. In addition, biochemical markers of oxidative stress (catalase, superoxide dismutase activity, and lipid peroxidation) were normalized by CHE treatment. The potential of CHE to prevent aluminium-induced neurotoxicity was reflected at the microscopic level, through the decrease of the number of eosinophilic necrosis phenotypes seen in treated groups. Moreover, the protective effect of CHE was similar to that of quercetin, which was taken as the standard. These findings showed that the CHE of cagaita leaves has a potential to protect the brain against oxidative-induced brain damage.

show abstract

“…Flavones are naturally occurring metabolites with a protective biochemical function mostly identi ed in recent studies [43,44]. It is well established that the protective effects of avonoids against heavy metal stress are mainly attributed to three mechanisms, including clearing reactive oxygen species, chelating heavy metals and reducing DNA damage [45,46].…”

Section: The Mechanisms Of Improving the Antioxidant Capacitymentioning

confidence: 99%

Comparative transcriptome combined with metabolome analyses revealed key factors involved in nitric oxide (NO)-regulated cadmium stress adaptation in tall fescue

Zhu

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background: It has been reported that nitric oxide (NO) could ameliorate cadmium (Cd) toxicity in tall fescue; however, the underlying mechanisms of NO mediated Cd detoxification are largely unknown. In this study, we investigated the possible molecular mechanisms of Cd detoxification process by comparative transcriptomic and metabolomic approaches. Results: The application of Sodium nitroprusside (SNP) as NO donor decreased the Cd content of tall fescue by 11% under Cd stress (T1 treatment), but the Cd content was increased by 24% when treated with Carboxy-PTIO (c-PTIO) together with Nitro-L-arginine methyl ester (L-NAME) (T2 treatment). RNA-seq analysis revealed that 904 (414 up- and 490 down-regulated) and 118 (74 up- and 44 down-regulated) DEGs were identified in the T1 vs Cd (only Cd treatment) and T2 vs Cd comparisons, respectively. Moreover, metabolite profile analysis showed that 99 (65 up- and 34-down- regulated) and 131 (45 up- and 86 down-regulated) metabolites were altered in the T1 vs Cd and T2 vs Cd comparisons, respectively. The integrated analyses of transcriptomic and metabolic data showed that 81 DEGs and 15 differentially expressed metabolites were involved in 20 NO-induced pathways. The dominant pathways were antioxidant activities such as glutathione metabolism, arginine and proline metabolism, secondary metabolites such as flavone and flavonol biosynthesis and phenylpropanoid biosynthesis, ABC transporters, and nitrogen metabolism.Conclusions: In general, the results revealed that there are three major mechanisms involved in NO-mediated Cd detoxification in tall fescue, including (a) antioxidant capacity enhancement; (b) accumulation of secondary metabolites related to cadmium chelation and sequestration; and (c) regulation of cadmium ion transportation, such as ABC transporter activation. In conclusion, this study provides new insights into the NO-mediated cadmium stress response.

show abstract

Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway

Cited by 97 publications

References 140 publications

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Antioxidant and Neuroprotective Properties of Eugenia dysenterica Leaves

Comparative transcriptome combined with metabolome analyses revealed key factors involved in nitric oxide (NO)-regulated cadmium stress adaptation in tall fescue

Contact Info

Product

Resources

About