Neuroprotective action of bacterial melanin in rats after corticospinal tract lesions

Effects of Bacterial Melanin on Movement, Posture, and Skilled Balancing Deficits After Unilateral Destruction of Substantia Nigra Pars Compacta in Rats

“…Balancing movements of the paralyzed hindlimb after the surgery recovered completely within 1-3 postoperative testing days. Earlier in the acute experiments, we have shown the favorable effect of the selected concentration of BM solution used in the present study (Petrosyan et al, 2012).…”

“…BM supports the survival of neurons in SNc after induced destruction and preserves dopaminergic cell bodies. The substance promotes also sprouting of nerve fibers, as it has been shown in series of experiments conducted in rats (Petrosyan et al, 2012).…”

Initial training facilitates posttraumatic motor recovery in rats after pyramidal tract lesion and in conditions of induced regeneration

“…BM has proved to be a potent stimulator of axonal growth and nerve fiber sprouting (Petrosyan et al 2012). In experiments on rats after motor tract lesion, BM showed a clear protective role, stimulating the regeneration of damaged motor tract fibers.…”

“…To make the study results more reliable, recovery of motor skills was evaluated also in conditions of stimulated regeneration. Bacterial melanin (BM) has proved to be a potent stimulator of axonal growth (Petrosyan et al 2012;Petrosyan and Gevorkyan 2013). In a previous series of experiments, BM was used to facilitate recovery processes in rats after unilateral ablation of the sensorimotor cortex that had caused paresis of limbs (Gevorkyan et al 2007(Gevorkyan et al , 2008.…”

“…A model of balancing ICR is used to assess the speed and pattern of recovery. In experiments with destruction of motor tracts in rats injected with BM, recovery of conductance in the motor tract and accelerated recovery of motor functions have been observed (Petrosyan 2008;Petrosyan et al 2012).…”