Neuroprotective Activity of Curcumin and<i>Emblica officinalis</i>Extract against Carbofuran‐Induced Neurotoxicity in Wistar Rats

Kuttan, Ramadasan; Binitha, Ponnamparambil Purushothaman

doi:10.1002/9781119155195.ch23

Cited by 5 publications

(1 citation statement)

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“…Because these cells are unable to boost glucose transport to offset the high quantity of glucose circulating in the circulation, this impaired response of the cells to insulin is possible. Peripheral insulin resistance (PIR) enhances the risk of several serious illnesses, including type 2 diabetes, heart disease, Alzheimer's disease, and stroke [25,26]. Another consequence of the increase in oxidative stress and the accumulation of HNE molecules, which are known to be associated with aging, is reduced neuronal glucose metabolism for energy production.…”

Section: Impaired Energy Metabolismmentioning

confidence: 99%

Untitled

2023

BJSTR

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Critical changes in cellular and molecular processes that occur with ageing disturb the central nervous system's homeostatic equilibrium. Metal accumulation makes the brain more vulnerable to neurotoxic shocks through mechanisms such mitochondrial failure, calcium-ion dyshomeostasis in neurons, a buildup of damaged molecules, reduced DNA repair, decreased neurogenesis, and impaired energy metabolism. These characteristics have been shown to be the cause of neuronal damage that result in a variety of neurological diseases. According to several studies, the development of neurodegenerative disorders including Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis is strongly correlated with metal buildup, aberrant protein expression, and protein synthesis. This review illustrates iron metal's accumulation and impacts on the development of neurological disorders in relation to the ageing brain.

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Section: Impaired Energy Metabolismmentioning

confidence: 99%