Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage

Lin, Yu; Chen, Hwei-Hsien; Ko, Chien-Hsin; Chan, Ming‐Huan

doi:10.1016/j.ejphar.2006.03.035

Cited by 123 publications

(80 citation statements)

References 25 publications

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“…Honokiol has also been found to have a variety of pharmacological action, such as antiinfl ammatory action (22), antithrombotic activity (23), anti-arrhythmic activity (24), neuroprotective activity (15), antioxidative action (25), and anxiolytic action (26). Numerous animal studies have also demonstrated that honokiol acts as an anti-stress agent and a potent suppressor of oxidative damage and cancer (27).…”

Section: Magnolol and Honokiolmentioning

confidence: 99%

“…The potent activity of honokiol and magnolol appears to be due to the presence of hydroxyl and allylic groups on a biphenolic moiety (10 Magnolol, a hydroxylated biphenyl compound isolated from the stem bark of Magnolia officinalis, is commonly used to treat acute pain, cough, anxiety, and gastrointestinal disorders in East Asia (11). Various pharmacological actions have been reported for magnolol, including anti-inflammatory activity, antimicrobial activity (12), antiperoxidative activity (13), anti-coagulatory activity, anti-oxidant activity (14), neuroprotective activity (15), antitumor action (16)(17)(18), alleviation of inflammatory pain (19), and protection of cortical neuronal cells from chemical hypoxia (20).…”

Section: Magnolol and Honokiolmentioning

confidence: 99%

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Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of <i>Magnolia officinalis </i>

Tang

Du³

et al. 2011

DD&T

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Magnolol and honokiol, main active compounds from the bark of Magnolia officinalis, have been found to have various pharmacological actions, including anti-oxidative, anti-inflammatory, anti-tumor, and anti-microbial properties, without appreciable toxicity. Recently, the anti-tumor activity of magnolol and honokiol has been extensively investigated. Magnolol and honokiol were found to possess anti-tumor activity by targeting the apoptosis pathways, which have been considered as targets for cancer therapies. This review will focus on the mechanisms by which magnolol and honokiol act on apoptosis pathways in cancer that have been characterized thus far, including the death receptormediated pathway, mitochondria-mediated pathway, caspase-mediated common pathway, and regulation of apoptosis-related proteins. These breakthrough findings may have important implications for targeted cancer therapy and modern applications of traditional Chinese medicine.

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Section: Magnolol and Honokiolmentioning

confidence: 99%

Section: Magnolol and Honokiolmentioning

confidence: 99%

Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of <i>Magnolia officinalis </i>

Tang

Du³

et al. 2011

DD&T

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“…1) is the major component isolated from the bark of the roots and stems of various Magnolia species (5). To date, various pharmacological effects of honokiol, such as neuroprotective, anticancer, cardiotonic, and anti-inflammatory activities have been reported (6)(7)(8). It is believed that the molecular mechanisms involved in honokiol pharmacology are managed by modulation of a signaling cascade composed of Ras, Raf, the extracellular signal-regulated kinase (ERK), and NF-κB/IκB kinase (IKK) in response to TNF-α or LPS stimulation and via control of the cellular redox system (9,10).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes

Lee¹,

Cho²

2009

BMB Reports

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“…Magnolol was also shown to protect neuronal cells against ischemia and chemical hypoxia damages [8,19]. In addition, honokiol and magnolol were recently shown to protect cerebellar granule cells from glucose deprivation-induced damage [25]. Furthermore, we showed that 4-O-methylhonokiol can prevent Ab 1-42 -induced memory impairment in mice by protecting neuronal cells damaged by Ab (unpublished data).…”

Section: Discussionmentioning

confidence: 82%

Neurite Outgrowth Effect of 4-O-methylhonokiol by Induction of Neurotrophic Factors Through ERK Activation

et al. 2009

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Compounds isolated from Magnolia officinalis such as magnolol, honokiol and obovatol exhibit several pharmacological effects on CNS including depressant, anxiolytic and anticonvulsant effects, as well as neuroprotective effects against chemical and heat damages. Recently, honokiol was found to have a neurotrophic effect in fetal rat cortical neurons. In the present study, we show that 4-O-methylhonokiol, a novel compound from Magnolia officinalis, promotes neurite outgrowth in a concentration- dependent manner in rat embryonic neuronal cells. In parallel with the neurite outgrowth activity, the expression of neurite outgrowth marker proteins is also increased by treatment with 4-O-methylhonokiol. We also found that 4-O-methylhonokiol promotes the release of NGF and BDNF into cell culture medium. In addition, lower concentration of 4-O-methylhonokiol (1 and 2 lM) further enhanced neurite outgrowth and expression of neurite outgrowth marker proteins in the presence of NGF (50 ng/ml) or BDNF (10 ng/ml). Subsequently, we found that 4-O-methylhonokiol activates ERK in a concentration- dependent manner. However, the neurite outgrowth activity and the NGF and BDNF release induced by 4-O-methylhonokiol are suppressed by an ERK-specific inhibitor. These results suggest that 4-O-methylhonokiol has the ability to induce neurite outgrowth via the increase of neurotrophic factor levels through ERK activation.

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Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage

Cited by 123 publications

References 25 publications

Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of <i>Magnolia officinalis </i>

Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of <i>Magnolia officinalis </i>

Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes

Neurite Outgrowth Effect of 4-O-methylhonokiol by Induction of Neurotrophic Factors Through ERK Activation

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