Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines

Protective effects of phenolic constituents from Cytisus multiflorus, Lamium album L. and Thymus citriodorus on liver cells

“…Besides these two compounds, the flavanone eriodictyol also showed high ROS scavenging capacity (about 50%). This fact is in accordance with previous literature data reporting a powerful antioxidant potential of this compound in several cellular models, including neuronal cell cultures, monocytes and retinal pigment epithelial ARPE-19 cells (Cho et al, 2012). One curious finding is the increase of ROS production caused by chrysin (Fig.…”

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

“…Pretreatment was required in many reported studies in which resveratrol was demonstrated to be neuroprotective, which is consistent with a preconditioning/hermetic mechanism of action Della-Morte et al, 2009;Khan et al, 2012). In addition to resveratrol, several other phytochemicals have been reported to activate SIRT1, including butein and fisetin (Howitz et al, 2003;Bauer et al, 2004;Wood et al, 2004), and are neuroprotective in one or more models (Burdo et al, 2008;Cho et al, 2012). Although activation of SIRT1 by phytochemicals can be neuroprotective, because SIRT1 activity consumes NAD + , it may hasten the demise of neurons under conditions of limited energy availability as may occur during cerebral ischemia .…”

Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-κB inhibition

“…Prior studies have shown that quercetin has a good capacity for scavenging ROS and yielding neuroprotection. Quercetin has been shown to inhibit LPS-induced upregulation of both iNOS and COX-2, as well as expression of p38 mitogen-activated protein kinase (p38-MAPK), TNF-α, and NF-кB [15,35,36] . Additionally, quercetin has been reported to reduce DNA fragmentation, the Bax/Bcl-2 ratio, nuclear translocation of apoptosis-inducing factor, and PARP cleavage [37] .…”