Neuroprotective and antioxidant activities of saponins’ mixture from Astragalus glycyphylloides in a model of 6-hydroxydopamine-induced oxidative stress on isolated rat brain synaptosomes

Kondeva-Burdina, Magdalena; Krasteva, Ilina; G, Popov; Manov, Vasil

doi:10.3897/pharmacia.66.e37997

Cited by 3 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the saponin neuroactivity could be a result of the p38 and p53 signal pathway mediation [ 87 ]. Isolated saponin from Astragalus glycyphylloides showed the most significant neuroprotective capacity, at 60 µg/mL, against oxidative stress in isolated brain synaptosomes [ 161 ].…”

Section: Neuroprotective Mechanistic Narratives Of Active Principles ...mentioning

confidence: 99%

Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules

Oyeyinka

Afolayan

2022

Foods

View full text Add to dashboard Cite

Active principles in plant-based foods, especially staple fruits, such as bananas and plantains, possess inter-related anti-inflammatory, anti-apoptotic, antioxidative, and neuromodulatory activities. Neurodegenerative diseases affect the functionality of the central and peripheral nervous system, with attendant cognitive deficits being hallmarks of these conditions. The dietary constitution of a wide range of bioactive compounds identified in this review further iterates the significance of the banana and plantain in compromising, halting, or preventing the pathological mechanisms of neurological disorders. The neuroprotective mechanisms of these biomolecules have been identified by using protein expression regulation and specific gene/pathway targeting, such as the nuclear and tumor necrosis factors, extracellular signal-regulated and mitogen-activated protein kinases, activator protein-1, and the glial fibrillary acidic protein. This review establishes the potential double-edged neuro-pharmacological fingerprints of banana and plantain fruits in their traditionally consumed pulp and less utilized peel component for human nutrition.

show abstract

Section: Neuroprotective Mechanistic Narratives Of Active Principles ...mentioning

confidence: 99%

Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules

Oyeyinka

Afolayan

2022

Foods

View full text Add to dashboard Cite

show abstract

“…Thus, neuroprotection is in direct connection with antioxidant activity [ 11 ]. Sub-cellular fractions (synaptosomes, mitochondria, and microsomes) are a convenient object for the investigation of neuronal damage and its mechanisms, as included in [ 14 ]. The availability of specific enzymes (incl.…”

Section: Introductionmentioning

confidence: 99%

Cycloartane Saponins from Astragalus glycyphyllos and Their In Vitro Neuroprotective, Antioxidant, and hMAO-B-Inhibiting Effects

et al. 2023

Self Cite

View full text Add to dashboard Cite

Astragalus glycyphyllos (Fabaceae) is used in the traditional medicine of many countries against hepatic and cardiac disorders. The plant contains mainly flavonoids and saponins. From a defatted methanol extract from its overground parts, a new triterpenoid saponin, 3-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-xylopyranosyl]-24-O-α-L-arabinopyranosyl-3β,6α,16β,24(R),25-pentahydroxy-20R-cycloartane, together with the rare saponin astrachrysoside A, were isolated using various chromatography methods. The compounds were identified via extensive high resolution electrospray ionisation mass spectrometry (HRESIMS) and NMR analyses. Both saponins were examined for their possible antioxidant and neuroprotective activity in three different in vitro models. Rat brain synaptosomes, mitochondria, and microsomes were isolated via centrifugation using Percoll gradient. They were treated with the compounds in three different concentrations alone, and in combination with 6-hydroxydopamine or tert-butyl hydroperoxide as toxic agents. It was found that the compounds had statistically significant dose-dependent in vitro protective activity on the sub-cellular fractions. The compounds exhibited a weak inhibitory effect on the enzyme activity of human recombinant monoamine oxidase type B (hMAO-B), compared to selegiline.

show abstract

Neurobiological Effects of Chemical Compounds of Species of the Genus <i>Astragalus</i> L. and Prospects for Their Use in Medicine (Review)

Berezutsky

Дурнова

Matvienko

2023

Razrabotka i registraciâ lekarstvennyh sredstv

View full text Add to dashboard Cite

Introduction. The genus Astragalus L. is one of the largest genera of flowering plants and includes at least 3,270 species. Individual species of this genus have long been used in traditional and scientific medicine. In recent years, species of the genus Astragalus L. have attracted attention because of the detection of a wide range of neurobiological effects in its representatives. The review presents an analysis of the literature data on experimental and partly clinical studies of various neurobiological effects of extracts and chemical compounds of species of this genus and the prospects for their use in medicine.Text. A variety of neuroprotective effects of these compounds has been established. In many cases, inhibition of oxidative stress, which plays an important role in the development of a number of neurodegenerative diseases, has been noted as a neuroprotective mechanism. Chemical compounds contained in representatives of this genus protect brain neurons from ischemic damage, the effects of neurotoxins and glutamate, and beta-amyloid deposition. These substances have been found to inhibit increased acetylcholinesterase activity and dimyelination processes. These compounds also improve cognitive functions, including memory and learning. Their anticonvulsant effect has been established. Of particular interest is the data indicating the possibility of using some chemical compounds contained in representatives of the genus Astragalus L. in therapy of mental diseases, particularly schizophrenia.Conclusion. The analysis of experimental works for the last ten years shows that extracts and chemical compounds of species of the genus Astragalus L. have a very heterogeneous spectrum of neurobiological action and, probably, may find application in the future as therapeutic agents in neurological and psychiatric practice. Unfortunately, in contrast to a large number of preclinical experiments, clinical trials of these compounds are sporadic. It is also noteworthy that less than one percent of the species of this genus have been investigated to date with respect to neurobiological activity. Thus, more extensive research, clinical trials, studies to standardize and establish therapeutic doses for humans of extracts and chemical compounds of species of the genus Astragalus L. are needed.

show abstract

Neuroprotective and antioxidant activities of saponins’ mixture from Astragalus glycyphylloides in a model of 6-hydroxydopamine-induced oxidative stress on isolated rat brain synaptosomes

Cited by 3 publications

References 9 publications

Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules

Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules

Cycloartane Saponins from Astragalus glycyphyllos and Their In Vitro Neuroprotective, Antioxidant, and hMAO-B-Inhibiting Effects

Neurobiological Effects of Chemical Compounds of Species of the Genus <i>Astragalus</i> L. and Prospects for Their Use in Medicine (Review)

Contact Info

Product

Resources

About