Neuroprotective and neuroregenerative effects of low-intensity aerobic exercise on sciatic nerve crush injury in mice

Bobinski, Franciane; Martins, Daniel Fernandes; Bratti, T.; Mazzardo-Martins, Leidiane; Winkelmann-Duarte, E.C.; Guglielmo, Luiz Guilherme Antonacci; Santos, Adair R.S.

doi:10.1016/j.neuroscience.2011.07.075

Cited by 113 publications

(114 citation statements)

References 56 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…In all three conditions, mechanical hyperalgesia was reduced compared with sedentary controls. However, the study, which was confirmed by a subsequent study, shows that exercise reduces local inflammatory mediators and nerve degeneration induced by the nerve injury (5,10). Thus the decrease in mechanical hyperalgesia in the nerve injury studies could be directly related to the decrease in inflammation and injury.…”

Section: Exercise Effects In Animal Models Of Painmentioning

confidence: 54%

Regular physical activity prevents development of chronic pain and activation of central neurons

Sluka

O’Donnell

Danielson

et al. 2013

Journal of Applied Physiology

167

168

View full text Add to dashboard Cite

show abstract

Section: Exercise Effects In Animal Models Of Painmentioning

confidence: 54%

Regular physical activity prevents development of chronic pain and activation of central neurons

Sluka

O’Donnell

Danielson

et al. 2013

Journal of Applied Physiology

167

168

View full text Add to dashboard Cite

show abstract

“…Functional motor recovery of 15 GSK3 S/A and 13 wt mice after SNC was determined by calculating the SSI as described previously 24,51 . Mice were lifted from the ground to photograph the left and right hind paws, respectively.…”

Section: Methodsmentioning

confidence: 99%

Sustained GSK3 activity markedly facilitates nerve regeneration

et al. 2014

View full text Add to dashboard Cite

Promotion of axonal growth of injured DRG neurons improves the functional recovery associated with peripheral nerve regeneration. Both isoforms of glycogen synthase kinase 3 (GSK3; a and b) are phosphorylated and inactivated via phosphatidylinositide 3-kinase (PI3K)/AKT signalling upon sciatic nerve crush (SNC). However, the role of GSK3 phosphorylation in this context is highly controversial. Here we use knock-in mice expressing GSK3 isoforms resistant to inhibitory PI3K/AKT phosphorylation, and unexpectedly find markedly accelerated axon growth of DRG neurons in culture and in vivo after SNC compared with controls. Moreover, this enhanced regeneration strikingly accelerates functional recovery after SNC. These effects are GSK3 activity dependent and associated with elevated MAP1B phosphorylation. Altogether, our data suggest that PI3K/AKT-mediated inhibitory phosphorylation of GSK3 limits the regenerative outcome after peripheral nerve injury. Therefore, suppression of this internal 'regenerative break' may potentially provide a new perspective for the clinical treatment of nerve injuries.

show abstract

“…Importantly, however, continuous exercise reverses this phenotypic change and normalizes pain thresholds (Groover et al, 2013). Finally, Schwann cell proliferation is increased following exercise and may play an important role in the increase in axonal regeneration necessary for appropriate response to peripheral nerve injury The benefits seen with peripheral nerve regeneration are significant enough to achieve improved values in both functional and morphological markers of nerve and motor function post exercise (Bobinski et al, 2011). These studies bolster the idea that axonal regeneration responds positively to exercise.…”

Section: Sensory Pathways Sensitive To Exercisementioning

confidence: 99%

Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain

2016

View full text Add to dashboard Cite

The utilization of physical activity as a therapeutic tool is rapidly growing in the medical community and the role exercise may offer in the alleviation of painful disease states is an emerging research area. The development of neuropathic pain is a complex mechanism, which clinicians and researchers are continually working to better understand. The limited therapies available for alleviation of these pain states are still focused on pain abatement and as opposed to treating underlying mechanisms. The continued research into exercise and pain may address these underlying mechanisms, but the mechanisms which exercise acts through are still poorly understood. The objective of this review is to provide an overview of how the peripheral nervous system responds to exercise, the relationship of inflammation and exercise, and experimental and clinical use of exercise to treat pain. Although pain is associated with many conditions, this review highlights pain associated with diabetes as well as experimental studies on nerve damages-associated pain. Because of the global effects of exercise across multiple organ systems, exercise intervention can address multiple problems across the entire nervous system through a single intervention. This is a double-edged sword however, as the global interactions of exercise also require in depth investigations to include and identify the many changes that can occur after physical activity. A continued investment into research is necessary to advance the adoption of physical activity as a beneficial remedy for neuropathic pain. The following highlights our current understanding of how exercise alters pain, the varied pain models used to explore exercise intervention, and the molecular pathways leading to the physiological and pathological changes following exercise intervention.

show abstract

Neuroprotective and neuroregenerative effects of low-intensity aerobic exercise on sciatic nerve crush injury in mice

Cited by 113 publications

References 56 publications

Regular physical activity prevents development of chronic pain and activation of central neurons

Regular physical activity prevents development of chronic pain and activation of central neurons

Sustained GSK3 activity markedly facilitates nerve regeneration

Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain

Contact Info

Product

Resources

About