Neuroprotective and Neurotrophic Effects of Quinic Acids from Aster scaber in PC12 Cells.

Abstract

Aster scaber T. (Asteraceae) has been used to treat bruises, snakebite, headache, and dizziness in traditional Chinese medicine. In the present study, the neuroprotective effect of four quinic acid derivatives from A. scaber on amyloid Abeta-induced PC12 cell toxicity was investigated. When cells were treated with quinic acid derivatives prior to Abeta, cell toxicity was significantly diminished. Among quinic acid derivatives, (-)4,5-dicaffeoyl quinic acid (1) gave the highest protection against Abeta-induced cell toxicity. In addition, the neurotrophic effects of compounds were evaluated by microscopically monitoring their potency to induce neurite outgrowth in PC12 cells. Four quinic acid derivatives from A. scaber promoted neurite outgrowth in PC12 cells. Interestingly, a novel quinic acid, (-)3,5-dicaffeoyl-muco-quinic acid (2) was more effective than the other compounds in promoting neurite outgrowth. Unlike nerve growth factor, the withdrawal of quinic acids did not result in any significant decrease in cell viability. The results suggest that quinic acid derivatives from A. scaber might potentially be used as a therapeutic agent in Alzheimer disease.

Importance of Espresso Coffee Machine Parameters on the Extraction of Chlorogenic Acids in a Certified Italian Espresso by Using SPE-HPLC-DAD

“…Caffeoylquinic acid derivatives, like 3-O-caffeoylquinic acid (3-CQA), 5-O-caffeoylquinic acid (5-CQA) and 3,5-di-O-caffeoylquinic acid (3,, are natural pohenolic compounds that have been isolated from a variety of traditional medicine plants and present a broad spectrum of pharmacological properties, including antioxidant, hepatoprotectant, antibacterial, antihistaminic and other biological effects (Basnet, Matsushige, Hase, Kadota, & Namba, 1996;Kwon, Jung, & Shin, 2000). Recently, it has been demonstrated that caffeoylquinic acid derivatives possess also neuroprotective effects (Hur, Soh, & Kim, 2001;Soh, Kim, Sohn, Lee, & Kim, 2003). More, it is reported that 3,5-diCQA exhibited neuroprotective properties against neuronal cell death that can be applied in the development of brain protection, as well as in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and ischemia (Kim, Park, Jeon, Kwon, & Chun, 2005).…”

Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study

“…Recently, increasing attention has been directed to CGA (the ester of caffeic acid with quinic acid), given its high abundance in coffee, its antioxidant activity (Gomez-Ruiz et al 2007;Zang et al 2003), and the suggestion that CGA and/or its metabolites are bioavailable in brain tissue (de Paulis et al 2002). CGA and its derivatives have displayed antioxidant and neuroprotective properties in models of neurodegenerative and pathological disease (Chu et al 2009;Han et al 2010;Hur et al 2001;Kim et al 2005;Silva et al 2004). In addition, there are reports of behavioral effects of CGA including the demonstration that CGA and/or its derivatives reduce anxiety-related behavior (Bouayed et al 2007), improve spatial learning and memory (Han et al 2010), and reduce behavioral deficits (Lapchak 2007) in a variety of in vivo animal models of disease or behavior.…”

Neuroprotective effects of 3,5-dicaffeoylquinic acid on hydrogen peroxide-induced cell death in SH-SY5Y cells

“…Recently, it has been demonstrated that caffeoylquinic acid derivatives possess neuroprotective effects in Aβ-induced PC12 toxicity (Hur et al, 2001) and tetrahydropapaveroline (THP)-induced C6 glioma cell death (Soh et al, 2003). However, the mechanism by which these caffeoylquinic acid derivatives exert neuroprotection is unclear.…”