2005
DOI: 10.1016/j.brainres.2004.11.019
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Neuroprotective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins

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Cited by 33 publications
(15 citation statements)
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“…1MeTIQ was found to inhibit binding of [ 3 H]MK-801 (dizocilpine) to isolated neuronal membranes (Kuszczyk et al 2010) and prevents glutamate-induced excitotoxicity and influx to neurons of calcium radio-labeled with the isotope 45 Ca (Antkiewicz-Michaluk et al 2006). What’s more, as was shown previously 1MeTIQ at concentrations of up to 500 μM does not decrease viability of neurons in primary culture, but exhibits neurotropic and neuroprotective properties (Antkiewicz-Michaluk et al 2006; Kotake et al 2005). In this study we investigated whether 1MeTIQ due to its NMDAR antagonistic properties can prevent Aβ evoked down-regulation of NMDAR associated proteins.…”
Section: Introductionsupporting
confidence: 59%
“…1MeTIQ was found to inhibit binding of [ 3 H]MK-801 (dizocilpine) to isolated neuronal membranes (Kuszczyk et al 2010) and prevents glutamate-induced excitotoxicity and influx to neurons of calcium radio-labeled with the isotope 45 Ca (Antkiewicz-Michaluk et al 2006). What’s more, as was shown previously 1MeTIQ at concentrations of up to 500 μM does not decrease viability of neurons in primary culture, but exhibits neurotropic and neuroprotective properties (Antkiewicz-Michaluk et al 2006; Kotake et al 2005). In this study we investigated whether 1MeTIQ due to its NMDAR antagonistic properties can prevent Aβ evoked down-regulation of NMDAR associated proteins.…”
Section: Introductionsupporting
confidence: 59%
“…It is well established by behavioral, biochemical ex vivo but also in vivo microdialysis studies, that both enantiomers (R)- and (S)- as well as racemic (R,S)-1MeTIQ demonstrate neuroprotective activity, as evidenced by their attenuation of the behavioral and biochemical effects of dopaminergic neurodegeneration induced by experimental neurotoxins such as: MPTP, 1BnTIQ, and rotenone (Antkiewicz-Michaluk et al 2003, 2004, 2011; Kotake et al 1995, 2005; Tasaki et al 1991). …”
Section: Neuroprotectionmentioning
confidence: 99%
“…Increasing evidence has suggested that neuroinflammation (kimCunningham et al, 2005; Herrera et al, 2005; Hong, 2005; Jenner, 2003; McGeer et al, 2001) and oxidative stress (Elkon et al, 2004; Jenner, 2003) are involved in the process of dopaminergic neuronal loss. Inflammation and oxidative stress mediated by activated microglia has been known to be a significant pathological feature of PD (Dexter et al, 1994; Jenner and Olanow, 1998), and that suppression of inflammation and oxidative stress from activated microglia is neuroprotective in various animal models of PD (Kotake et al, 2005; Li et al, 2005a; Liu et al, 2003; Sherer et al, 2003; Testa et al, 2005; Wu et al, 2002). …”
Section: Introductionmentioning
confidence: 99%