Neuroprotective effect of acute interferon-beta 1b treatment after spinal cord injury

Sengul, Goksin; Çoban, Mustafa Kemal; Çakır, Mürteza; Coşkun, Şahin; Aksoy, Hülya; Hacımüftüoğlu, Ahmet; Saruhan, Fatih; Calik, Muhammed

doi:10.5137/1019-5149.jtn.6651-12.1

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…Sengul et al reported that histopathological evaluation in the physiological saline group showed a considerable increase in hemorrhage, edema, neuronal degeneration, and inflammation in a spinal cord injury model (36). In the present study, considerable laceration, diffuse hemorrhage, intense edema, and neuronal degeneration (Nissl losses and red degeneration) were observed in the gray matter and edema, intense axonal degeneration, and spherule structures were observed in the white matter in the sham group (Figure 3B).…”

Section: A B C Dsupporting

confidence: 62%

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Investigation of neuroprotective and therapeutic effect of hesperidin in experimental spinal cord injury

Yurtal¹,

Altuğ²,

Ünsaldi³

et al. 2020

Turkish Neurosurgery

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AIM:To investigate the neuroprotective and therapeutic efficacy of hesperidin against secondary damage following traumatic spinal cord injury. MATERIAL and METHODS:A total of 32 male Wistar albino rats weighing 250-300 g were randomly divided into four groups (n=4): group I, control group; group II, sham group; group III, preconditioning group, and group IV, treatment group. A rat model of spinal cord injury was established by dropping a weight of 100 g/cm on the spinal cord exposed at T7-T10 with dorsal laminectomy. In neurological examination after the trial period, inclined planed test, modified Tarlov scale, and finger extension test were performed. Furthermore, the bioefficacy of hesperidin was investigated histopathologically, biochemically, and immunohistochemically using blood and tissue samples obtained from the experimental animals. RESULTS:Neurological examination following spinal cord injury revealed that hesperidin significantly contributed to improvement in the 24-hour period. Biochemical analyses revealed that hesperidin showed anti-inflammatory effects by decreasing IL-1β and TNF-α levels at the 24th hour as well as strong antioxidant activity by increasing TAS levels in groups III and IV. Histopathologically, hesperidin reduced hemorrhage, laceration, axonal and neuronal degeneration, necrosis, inflammatory reaction, and edema in groups III and IV. Immunohistochemically, hesperidin reduced the number of caspase 3-positive apoptotic cells in groups III and IV. CONCLUSION:Hesperidin showed antioxidant, anti-inflammatory, and anti-apoptotic effects during the acute period following spinal cord injury; thus, hesperidin shows neuroprotective and therapeutic efficacy in spinal cord injury.

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Section: A B C Dsupporting

confidence: 62%

“…against spinal cord injuries are aimed at preventing secondary injuries (36). Contusion models are important tools for exploring progressive secondary tissue injury, demyelination, and apoptosis in spinal cord injury (40).…”

Section: A B C Dmentioning

confidence: 99%

Investigation of neuroprotective and therapeutic effect of hesperidin in experimental spinal cord injury

Yurtal¹,

Altuğ²,

Ünsaldi³

et al. 2020

Turkish Neurosurgery

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“…With respect to other therapies involving chaperones, improvement in functional recovery in rats with a contusion spinal cord injury following interferon-beta 1b treatment was found to be related to enhanced HSP70 expression in the cord along with reduced polymorphonuclear leucocyte infiltration, hemorrhage, oedema and necrosis (Sengul et al, 2013 ). An interesting therapeutic intervention in spinal cord injury experiments has been the use of exercise in injured animals.…”

Section: Therapeutic Strategies That Involve Chaperonesmentioning

confidence: 99%

Chaperone Proteins in the Central Nervous System and Peripheral Nervous System after Nerve Injury

2017

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Injury to axons of the central nervous system (CNS) and the peripheral nervous system (PNS) is accompanied by the upregulation and downregulation of numerous molecules that are involved in mediating nerve repair, or in augmentation of the original damage. Promoting the functions of beneficial factors while reducing the properties of injurious agents determines whether regeneration and functional recovery ensues. A number of chaperone proteins display reduced or increased expression following CNS and PNS damage (crush, transection, contusion) where their roles have generally been found to be protective. For example, chaperones are involved in mediating survival of damaged neurons, promoting axon regeneration and remyelination and, improving behavioral outcomes. We review here the various chaperone proteins that are involved after nervous system axonal damage, the functions that they impact in the CNS and PNS, and the possible mechanisms by which they act.

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“…SKY, lokal ve sistemik sekonder mekanizmaları tetikleyerek, esas olarak yaygın hücre ölümünden sorumlu olan kronik bir inflamatuar duruma neden olur [15]. Omurilik yaralanmalarında birincil yaralanmayı önlemenin imkânsız olmasından dolayı araştırmacıların geliştirmeye çalıştığı tedavi stratejileri ikincil yaralanmaları önlemeyi amaçlamaktadır [16]. Erken evrede, klinikte omurilik yaralanmasının geleneksel tedavisi, yüksek dozlarda metilprednizolon (MP) ile kombine cerrahi tedavidir [17].…”

Section: Discussionunclassified

Ratlarda deneysel spinal kord yaralanmasında Hesperidin’in nöroprotektif etkisi

Aydın¹,

Keskin²

2022

Pamukkale Medical Journal

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Bu çalışmada, ratlarda deneysel omurilik yaralanmasında farklı dozlarda hesperidinin (HSP) oksidatif hasara karşı koruyucu etkisini histopatolojik ve biyokimyasal değerlendirmeler kullanarak araştırmayı amaçladık. Gereç ve yöntem: Çalışma 4 grup ve her grupta 10 adet Wistar albino cinsi rat olacak şekilde planlandı. Grup 1 (kontrol grubu): laminektomi yapıldı. Laminektomi sonrası üç gruba (G2, G3, G4) travma uygulandı. Grup 2 (patoloji grubu): laminektomi yapıldı ve ekstradural klip uygulandı. Grup 3 (düşük doz HSP): laminektomi yapılıp, ekstradural klip uygulandı ve tek doz düşük doz HSP intraperitoneal olarak verildi (50 mg/kg). Grup 4 (yüksek doz HSP): laminektomi yapılıp, ekstradural klip uygulandı ve tek doz yüksek doz HSP intraperitoneal olarak verildi (100 mg/kg). Nöroprotektif etkiyi değerlendirmek için alınan doku örnekleri biyokimyasal ve histopatolojik olarak incelendi. Bulgular: Travma gruplarındaki inflamatuar bulgular ve nöron sayısının morfometrik sonuçları, Grup 4'te diğer gruplara kıyasla istatiksel olarak anlamlı şekilde daha iyiydi. Klinik motor muayene ve eğik düzlem test sonuçları açısından gruplar arasında fark yoktu. Her iki tedavi grubunda (Grup3, Grup4), lipid peroksidasyonunun son ürünü olan malondialdehit anlamlı bir farklılık gözlemlenmezken (p>0,05); total antioksidan plazma seviyelerinde kontrol ve patoloji gruplarına kıyasla istatistiksel olarak anlamlı bir farklılık gözlemlendi (p:0,001). Sonuç: Sonuçlarımız, yüksek doz HSP' nin spinal kord hasarında nöronların sayısındaki azalmaya olumlu etkisi ve hafif dejenerasyon bulguları ile neuroprotektif etki sağlayabileceğini düşündürmektedir.

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Neuroprotective effect of acute interferon-beta 1b treatment after spinal cord injury

Cited by 7 publications

References 13 publications

Investigation of neuroprotective and therapeutic effect of hesperidin in experimental spinal cord injury

Investigation of neuroprotective and therapeutic effect of hesperidin in experimental spinal cord injury

Chaperone Proteins in the Central Nervous System and Peripheral Nervous System after Nerve Injury

Ratlarda deneysel spinal kord yaralanmasında Hesperidin’in nöroprotektif etkisi

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