Neuroprotective effect of antioxidants on ischaemia and reperfusion-induced cerebral injury

Gupta, R. C.; Singh, Manjeet; Sharma, Ajay

doi:10.1016/s1043-6618(03)00102-6

Cited by 153 publications

(92 citation statements)

References 29 publications

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“…The remaining flavonoid fractions (approximately 15%) include at least 17 more components. Among the flavonoids, quercetin and its dimerized compound show the highest antioxidant activities, which are similar to those displayed by α-tocopherol: antiulcer, antispasmodic, antidiarrheal (Corea et al 2005), anti-HIV (Gupta et al 2003), anticholesterolic, against cardiovascular diseases (Wang, Ng 1999;Fahs, Faucher 2002). Quercetin also shows antiviral activity and enhances the bioavailability of some antiviral drugs (Wu et al 2005).…”

Section: Bulb Quality and Biological Propertiesmentioning

confidence: 79%

Interactions among genotype, environment and agronomic practices on production and quality of storage onion (Allium cepa L.) - A review

Sękara¹,

Pokluda²,

Vacchio³

et al. 2017

Hortic. Sci.

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Sekara A., Pokluda R., Del Vacchio L., Somma S., Caruso G. (2017) The aim of this review is a wide description of the relationships between growing conditions and bulb yield and quality of onion (Allium cepa L.), focused particularly on long-day cultivars suitable for storage. Marketable yield decreases according to the reduction of crop length caused by the increase of growth temperature. The nutritive requirements of storage onion are highest during the vegetative growth. The application of humic substances and the inoculation of mycorrhizae may enhance bulb growth and quality, mainly under stress conditions. Onion is a slow-growth, shallowrooted crop with non-shading habitus and therefore its productivity is highly dependent on water availability in the soil, proper fertilization and weed control. The shelf-life of onion bulbs is a genetic trait, improvable by efficient crop and post-harvest management, and adequate conditions of bulb storage. The quality of storage onion bulbs is ascribed to several indicators, such as thiosulfonates, pyruvic acid, soluble solids, sugars, and many other biological compounds. This review is also focused on onion quality as affected by the interactions among genotype, environment, farming practices and post-harvest management.

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Section: Bulb Quality and Biological Propertiesmentioning

confidence: 79%

Interactions among genotype, environment and agronomic practices on production and quality of storage onion (Allium cepa L.) - A review

Sękara¹,

Pokluda²,

Vacchio³

et al. 2017

Hortic. Sci.

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“…They have also been reported to rescue spatial memory impairment in rats with ischemia-reperfusion-induced cerebral injury (Pu et al, 2007). Rutin was also noted to decrease mitochondrial TBARS (Gupta et al, 2003) and to attenuate morphological damage and ischemic apoptosis (Khan et al, 2009).…”

Section: Discussionmentioning

confidence: 96%

Protective effects ofHammada scopariaflavonoid-enriched fraction on liver injury induced by warm ischemia/reperfusion

Saidi

Bourogâa

Bouaziz

et al. 2015

Pharmaceutical Biology

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Context: Hepatic ischemia/reperfusion injury (IRI) is a major cause of liver damage during liver surgery and transplantation. Plants have historically been used in treating liver damage, and Hammada scoparia (Pomel) (Chenopodiaceae) has been reported to possess a broad spectrum of pharmacological and therapeutic activities. Objective: In this study, a flavonoid-enriched fraction was used before the warm ischemia (WI) process as pharmacological preconditioning and in combination with technical postconditioning to evaluate their protective effects. Materials and methods: The rats were divided into five groups: a sham group; a control group (Control-IR) that was submitted to 60 min WI; a Pharmacological Preconditioning group (PreC-IR) that received flavonoid-enriched fraction (200 mg/kg body weight); a Postconditioning group (PostC) and a PreC + PostC group. Results: The use of the flavonoid-enriched fraction was noted to significantly (p50.05) reduce liver injury, as evidenced by the decrease in liver transaminase activities (AST and ALT) and lactic dehydrogenase (LDH), alkaline phosphatase (ALP), and lipid peroxidation (TBARS), levels as well as the enhancement of antioxidant enzymes (catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)) responses. The results also indicated that, compared with the separate application of pharmacological preconditioning and postconditioning, the combination of both treatments was more effective in reducing tissue oxidative stress levels through modulating SOD, GSH-PX, and CAT activities. Furthermore, the combined protocol further decreased the liver morphological score compared with solo treatment. Discussion and conclusion: Overall, the results indicate that the H. scoparia flavonoid-enriched fraction could be a promising candidate for future application as a pharmacological preconditioning agent against hepatic IRI.

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“…Selenite increases cell proliferation through the upregulation of Bcl-2 expression, mitochondrial membrane potential, ATP generation, and glucose uptake mediated by PI3K pathway. Selenite, as an antioxidant, can also block apoptosis induced by H 2 O 2 , which is related to blocking ASK1 activity and further stimulating the activation of the PI3K/AKT pathway [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Neuroprotection of selenite against ischemic brain injury through negatively regulating early activation of ASK1/JNK cascade via activation of PI3K/AKT pathway

Wang

Zhang

et al. 2007

Acta Pharmacologica Sinica

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Aim: To investigate whether selenite, a known antioxidant, could decrease the activation of apoptosis signal regulating kinase 1/c-jun N-terminal kinase (ASK1/ JNK) signaling cascade in cerebral ischemia/reperfusion (I/R) by activating the phosphatidylinositol 3-kinase (PI3K)/AKT pathway in rat hippocampi, and the neuroprotective effect of selenite against ischemic injury after 15 min of transient brain ischemia. Methods: Transient global brain ischemia was induced by 4-vessel occlusion into adult male Sprague-Dawley rats weighing 250-300 g. The rats were pretreated only with selenite (0.3 mg/kg dissolved in 0.9% saline) every 24 h for 7 d by means of intravenous injection of the tail or combined with LY294002 from d 5 by left cerebral ventricle injection before surgery. Results: Selenite significantly increased AKT1 activation and decreased the activation of ASK1/ JNK cascade via phosphorylating ASK1 at Ser-83 residue by AKT1 during early reperfusion after 15 min transient global brain ischemia. On the contrary, combined pretreatment of the rats with LY294002 (a specific PI3K inhibitor) and selenite significantly inhibited the effects solely with selenite. Conclusion: The activation of the pro-apoptotic ASK1/JNK cascade, which is closely associated with oxidative stress, could be suppressed by selenite through activating the antiapoptotic PI3K/AKT pathway during early reperfusion after cerebral ischemia in rat hippocampi.

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Neuroprotective effect of antioxidants on ischaemia and reperfusion-induced cerebral injury

Cited by 153 publications

References 29 publications

Interactions among genotype, environment and agronomic practices on production and quality of storage onion (Allium cepa L.) - A review

Interactions among genotype, environment and agronomic practices on production and quality of storage onion (Allium cepa L.) - A review

Protective effects ofHammada scopariaflavonoid-enriched fraction on liver injury induced by warm ischemia/reperfusion

Neuroprotection of selenite against ischemic brain injury through negatively regulating early activation of ASK1/JNK cascade via activation of PI3K/AKT pathway

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