Neuroprotective Effect of Apigenin on Depressive-Like Behavior: Mechanistic Approach

Bijani, Soroush; Dizaji, Rana; Sharafi, Ali; Hosseini, Mir-Jamal

doi:10.1007/s11064-021-03473-0

Cited by 28 publications

(18 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apienin, luteolin and rosmarinic acid of P. frutescens have been showed their possibility potential for anti-COVID-19 as the inhibitors [ 43 , [49] , [50] , [51] ]. The active constituents- apigenin, caffeic acid and chlorogenic acid in P. cablin showed that anti-inflammtory activity of apigenin in the dose at 20 mg/kg for tested animals on escalating the inflammatory and oxidative response [52] . Caffeic acid and chlorogenic acid also inhibited pro-inflammatory TNF-α and H 2 O 2 -induced IL-8 production [53] .…”

Section: Resultsmentioning

confidence: 96%

Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development

Tsai

Hsieh

Ting

et al. 2022

Journal of the Taiwan Institute of Chemical Engineers

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 96%

Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development

Tsai

Hsieh

Ting

et al. 2022

Journal of the Taiwan Institute of Chemical Engineers

View full text Add to dashboard Cite

“…It seems that an increase in ROS levels subsequently leads to oxidative damage and pathogenesis of transient cerebral ischemia or stroke. The elevation in ROS production stimulated interaction with macromolecules and activation of cell death signaling pathways [ 21 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…The FRAP test is designed to measure the total level of cellular antioxidants using 2,4,6-Tri(2-pyridyl)-s-triazine (TPTZ) as the sensitive reagent. The rise in absorbance at 593 nm was determined by the antioxidant activity of the generated ferrous ions [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery

Mozafari

Rashidzadeh

Bijani

et al. 2023

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

Ischemic stroke is the most common among various stroke types and the second leading cause of death, worldwide. Edaravone (EDV) is one of the cardinal antioxidants that is capable of scavenging reactive oxygen species, especially hydroxyl molecules, and has been already used for ischemic stroke treatment. However, poor water solubility, low stability, and bioavailability in aqueous media are major EDV drawbacks. Thus, to overcome the aforementioned drawbacks, nanogel was exploited as a drug carrier of EDV. Furthermore, decorating the nanogel surface with glutathione as targeting ligands would potentiate the therapeutic efficacy. Nanovehicle characterization was assessed with various analytical techniques. Size (199 nm, hydrodynamic diameter) and zeta potential (-25 mV) of optimum formulation were assessed. The outcome demonstrated a diameter of around 100 nm, sphere shape, and homogenous morphology. Encapsulation efficiency and drug loading were determined to be 99.9% and 37.5%, respectively. In vitro drug release profile depicted a sustained release process. EDV and glutathione presence in one vehicle simultaneously made the possibility of antioxidant effects on the brain in specific doses, which resulted in elevated spatial memory and learning along with cognitive function in Wistar rats. In addition, significantly lower MDA and PCO and higher levels of neural GSH and antioxidant levels were observed, while histopathological improvement was approved. The developed nanogel can be a suited vehicle for drug delivery of EDV to the brain and improve ischemia-induced oxidative stress cell damage.

show abstract

“…This flavonoid attenuated CUMS-induced depressive-like behaviors and attenuated the increase in HMGB1/TLR4/NFκB expression [151]. Other flavonoids, such as flavones, apigenin, and hesperidin, demonstrated antidepressant effects by inhibiting TLR4 signaling in animal models [70,152,153]. Finally, curcumin, the yellow pigment in Indian saffron, isolated from the rhizome of Curcuma longa, has been investigated as a neuroprotective agent in several pathological conditions [154].…”

Section: Tlr4 In Mood Disorders and Evidence Of Antidepressant Effect...mentioning

confidence: 99%

Toll-like receptor 4 in the interface between neuroimmune response and behavioral alterations caused by stress

Souza-Junior

Cunha

Lisboa

2022

Explor Neuroprot Ther

View full text Add to dashboard Cite

Different stressors can elicit neuroinflammatory responses modulated by innate immunity receptors, such as the family of Toll-like receptors (TLRs). The TLR4, a pattern recognition receptor (PRR), is involved in many diseases, such as inflammatory and central nervous system (CNS) diseases. Stress exposure can regulate the expression of PRRs, including TLR4, in the brain of animals, especially in the hippocampus and prefrontal cortex. Moreover, TLR4 modulates behavior and neuroinflammatory responses in the brain. In addition, to TLR4, the endocannabinoid (eCB) system plays a role in stress response and immunity, acting as a regulatory, stress-buffer system. This system is involved in many TLRs-mediated immune responses, such as microglia activation. Therefore, pharmacological approaches targeting the eCB system could modulate neuroinflammatory responses to stress by interfering with the TLR4 pathway. Although the connection between TLR4, stress, and neuroinflammation is well documented, almost no pre-clinical studies investigate the possible direct relationship between TLR4, behavior, stress, and the eCB system. Studies exploring the relationship between stress, neuroinflammation, TLR4, and the eCB system were searched using Pubmed, Web of Science, and Embase databases. Based on this search, this review is focused on the involvement of TLR4 receptors and signaling in neuroinflammation and the behavioral consequences of stress exposure. Moreover, evidence of the eCB system modulating TLR4-mediated responses was brought to the attention, pointing out a possible regulatory role of these responses by eCBs in behavior changes related to mood disorders.

show abstract

Neuroprotective Effect of Apigenin on Depressive-Like Behavior: Mechanistic Approach

Cited by 28 publications

References 47 publications

Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development

Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development

Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery

Toll-like receptor 4 in the interface between neuroimmune response and behavioral alterations caused by stress

Contact Info

Product

Resources

About