Neuroprotective Effect of Bioflavonoids Against Carbon Tetrachloride Induced Neurotoxicity in Rats

Abstract

The present study was undertaken to explore the neuroprotective potential of bioflavonoids against carbon tetrachloride (CCl4) induced neurotoxicity in rats. Neurotoxicity was induced by CCl4 (3ml/kg body weight) in wistar rats. Blood biochemical, hematological parameters and histopathological studies were carried out to assess the neuroprotective effect. Administration of CCl4 has induced significant neurotoxicity in rats, which was evident from enhanced levels of potassium and decreased levels of sodium. Pretreatment with quercetin (50 mg/kg dose orally) significantly reversed CCl4 induced neurotoxicity than the silymarin (50 mg/kg dose orally). From the obtained results it can be concluded that quercetin exerted a significant neuroprotective effect against CCl4 induced neurotoxicity in rats than silymarin (p<0.001) for sodium and potassium in blood biochemical parameters, packed cell volume, mean corpuscular hemoglobin count and red blood cells as well in attenuation of pathological changes in brain tissues.