Neuroprotective Effect of Corosolic Acid Against Cerebral Ischemia-Reperfusion Injury in Experimental Rats

Abstract

IntroductionStroke is a devastating disease that affects individuals around the world, often leaving them permanently disabled and unable to think clearly 1,2) . More than 15 million people worldwide are affected by stroke, according to the World Health Organization. Ischemic strokes account for 87％ of all strokes 3) . A thromboembolic occlusion of the cerebral arteries outcomes in an ischemic cascade as well as tissue damage 4,5) . Over the past several decades, estimates of the prevalence of cerebral ischemia have steadily increased 6) . For researchers, the treatment of cerebral ischemia continues to be a significant problem 7,8) . The disease has been linked to neurovascular units, and researchers have been focusing on the neurovascular unit (NVU) as a whole-disease therapy 9) , which has shown to be protective against neuronal injury, neurons, and the blood-brain barrier (BBB) , including extracellular matrix, vascular endothelial

Corosolic acid attenuates cardiac ischemia/reperfusion injury through the PHB2/PINK1/parkin/mitophagy pathway

“…49 Additional, CA also had defensive functions against non-alcoholic steatohepatitis brought on by a high-fat diet and carbon tetrachloride, 50 cerebral I/R injury, liver cancer, and colorectal cancer. 51 , 52 , 53 The studies revealed that CA has numerous biological impacts and merits further, in-depth investigation. We anticipated that CA had protective effects against heart harm caused by I/R in light of the cardiomyocyte protection it provided in other studies.…”