Neuroprotective effect of Da Chuanxiong Formula against cognitive and motor deficits in a rat controlled cortical impact model of traumatic brain injury

Liu, Zhi Ke; Ng, Chun Fai; Shiu, Hoi Ting; Wong, Hai Ming; Chin, Wai; Zhang, Jin Fang; Lam, P. M.; Poon, Wai-sang; Lau, Clara Bik‐San; Leung, Ping Chung; Ko, Chun‐Hay

doi:10.1016/j.jep.2018.02.004

Cited by 32 publications

(24 citation statements)

References 48 publications

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“…Treatment with DCXF aqueous extract 1 week before and 11 days after the induction TBI by a CCI model in rat improved the learning ability, memory retention, and proliferation of neural stem cells (NSCs). Results also showed that DCXF reduced activation of astrocytes and microglia, BBB permeability, brain edema, and neuronal loss in the brain with TBI …”

Section: Resultsmentioning

confidence: 86%

“…In a CCI model of TBI, it was shown that DCXF aqueous extract improved the proliferation of NSCs and reduced BBB damage as well as brain edema. This also alleviated the neuronal loss and improvement in neurological functions including learning, memory, and motor abilities mainly through inhibition of inflammation process . The protective effect of breviscapine on neurobehavioral disorders after TBI may be associated with its mechanism of improving energy metabolism, free radical scavenging, inhibition of intracellular Ca 2+ , overload, excitatory amino acid toxicity, inflammatory suppression, regulation of brain blood vessel activity, and suppression of IL‐6 expression .…”

Section: Molecular Mechanisms Underlying the Neuroprotective Effects mentioning

confidence: 99%

“…Results also showed that DCXF reduced activation of astrocytes and microglia, BBB permeability, brain edema, and neuronal loss in the brain with TBI. 16 3.10 | Erigeron breviscapus E. breviscapus known as "Dengzhanxixin," belonging to the Asteraceae family, is a plant species endemic to southwestern China. It has been used in traditional Chinese medicine for various conditions including digestive disorders, heart disease, cerebral infarction, and apoplexy.…”

Section: Crocus Sativusmentioning

confidence: 99%

“…This also alleviated the neuronal loss and improvement in neurological functions including learning, memory, and motor abilities mainly through inhibition of inflammation process. 16 The protective effect of breviscapine on neurobehavioral disorders after TBI may be associated with its mechanism of improving energy metabolism, free radical scavenging, inhibition of intracellular Ca 2+ , overload, excitatory amino acid toxicity, inflammatory suppression, regulation of brain blood vessel activity, and suppression of IL-6 expression. 17,208,209 The protective effect of G. elata on TBI could be associated with the reduction of pro-inflammatory cytokines, inflammation, and astrocytes' accumulation.…”

Section: Molecular Mechanisms Underlying the Neuroprotective Effectmentioning

confidence: 99%

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Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies with Actaea racemosa, Artemisia annua, Aframomum melegueta, Carthamus tinctorius, Cinnamomum zeylanicum, Crocus sativus, Cnidium monnieri, Curcuma longa, Gastrodia elata, Malva sylvestris, Da Chuanxiong Formula, Erigeron breviscapus, Panax ginseng, Salvia tomentosa, Satureja khuzistanica, Nigella sativa, Drynaria fortune, Dracaena cochinchinensis, Polygonum cuspidatum, Rosmarinus officinalis, Rheum tanguticum, Centella asiatica, and Curcuma zedoaria show a significant decrease in neuronal injury by different mechanisms such as increasing superoxide dismutase and catalase activities, suppressing nuclear factor kappa B (NF‐κB), interleukin 1 (IL‐1), glial fibrillary acidic protein, and IL‐6 expression. The aim of this study was to evaluate the neuroprotective effects of medicinal plants in central nervous system pathologies by reviewing the available literature.

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Section: Resultsmentioning

confidence: 86%

Section: Molecular Mechanisms Underlying the Neuroprotective Effects mentioning

confidence: 99%

Section: Crocus Sativusmentioning

confidence: 99%

Section: Molecular Mechanisms Underlying the Neuroprotective Effectmentioning

confidence: 99%

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Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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“…In animal studies of immature cortices, A. sinensis demonstrated neuroprotective effects following hypoxic brain damage [52]. Gastrodia elata can reduce brain edema and neuronal loss, and improve neural stem cell proliferation [53]. Paeoniflorin, extracted from Paeonia lactiflora, can suppress neuronal apoptosis and promote neurogenesis [51].…”

Section: Cerebral Infarction and Intracranial Hemorrhagementioning

confidence: 99%

Effect of Traditional Chinese Medicine on Long-Term Outcomes of Snakebite in Taiwan

Huang

Hsieh

2020

Toxins

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Herein, we review the characteristics of the six predominant venomous snakes in Taiwan and the effects of traditional Chinese medicine on the long-term outcomes of snakebite venom. We electronically searched databases, including PubMed, ClinicalKey, China National Knowledge Infrastructure, National Digital Library of Theses and Dissertations in Taiwan, and Airiti Library, from their inception to November 2019 by using the following Medical Subject Headings’ keywords: snakebite, long-term, chronic, Chinese medicine, CAM, herb, and Taiwan. The most common long-term effects of snakebite envenomation include “migraine-like syndrome”, brain injuries caused by hypoxia or intracranial hemorrhage, and chronic kidney disease. In addition, hypopituitarism is also worth mentioning. Traditional Chinese medicine can potentially be used in a complementary or alternative treatment for these effects, but additional studies are needed.

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Chinese herbal medicine in brain injury and other neurological disorders

Liu

Hung

et al. 2023

Treatments, Nutraceuticals, Supplements, and Herbal Medicine in Neurological Disorders

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Neuroprotective effect of Da Chuanxiong Formula against cognitive and motor deficits in a rat controlled cortical impact model of traumatic brain injury

Cited by 32 publications

References 48 publications

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Effect of Traditional Chinese Medicine on Long-Term Outcomes of Snakebite in Taiwan

Chinese herbal medicine in brain injury and other neurological disorders

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