2018
DOI: 10.1016/j.nano.2018.01.020
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Neuroprotective effect of gold nanoparticles composites in Parkinson's disease model

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Cited by 92 publications
(43 citation statements)
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“…The CTS@GNP-pDNA-NGF systems that resulted were transfected into cells by NGF receptor-mediated endocytosis, in order to suppress the expression of α-syn and inhibit the apoptosis of PC12 cells and substantia nigra striatum dopaminergic neurons. The data confirmed that CTS@GNP-pDNA-NGF presented notable therapeutic properties in both in vitro and in vivo PD models [125].…”
Section: Current Research Advances In Nanoparticle-based Treatmentsupporting
confidence: 67%
“…The CTS@GNP-pDNA-NGF systems that resulted were transfected into cells by NGF receptor-mediated endocytosis, in order to suppress the expression of α-syn and inhibit the apoptosis of PC12 cells and substantia nigra striatum dopaminergic neurons. The data confirmed that CTS@GNP-pDNA-NGF presented notable therapeutic properties in both in vitro and in vivo PD models [125].…”
Section: Current Research Advances In Nanoparticle-based Treatmentsupporting
confidence: 67%
“…90 There are also many reports indicating the advantages of using NPs in PD therapy. 10 Hu et al 91 analyzed Au NPs loaded with plasmid DNA and obtained through the combination of electrostatic adsorption and photochemical immobilization methods with regard to their therapeutic effects in PD models. 91 The authors observed that these systems could successfully cross the BBB and inhibit the apoptosis of PC12 cells and dopaminergic neurons in PD mice brain.…”
Section: Neurodegenerative Diseasesmentioning
confidence: 99%
“…10 Hu et al 91 analyzed Au NPs loaded with plasmid DNA and obtained through the combination of electrostatic adsorption and photochemical immobilization methods with regard to their therapeutic effects in PD models. 91 The authors observed that these systems could successfully cross the BBB and inhibit the apoptosis of PC12 cells and dopaminergic neurons in PD mice brain. In a study conducted by Cao et al, 92 rat models of PD were separately given chitosan-coated levodopa liposomes/benserazide and levodopa/benserazide.…”
Section: Neurodegenerative Diseasesmentioning
confidence: 99%
“…Alternatively, suppression of α-syn overexpression has been demonstrated using gold NPs which could load plasmid DNA, cross the blood–brain barrier and target specific cells. For example, the group of Y. Guan achieved successful results in carrying pDNA into the neurons, and thus inhibiting dopaminergic neuron apoptosis (Hu et al, 2018). These approaches have the potential to suppress α-syn expression, providing a highly efficient treatment for PD.…”
Section: New Technologies For the Diagnosis Clinical Assessment And mentioning
confidence: 99%