Neuroprotective effect of histamine H3 receptor blockade on methamphetamine-induced cognitive impairment in mice

Luo, Hu; Li, Xiaofang; Fan, Runyue; Ruan, Yuer; Qian, Liyin; Shen, Yao; Si, Zizhen; Li, Longhui; Liu, Yu

doi:10.1016/j.pbb.2022.173512

Cited by 5 publications

(3 citation statements)

References 57 publications

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“…Since METH exposure can also lead to poor performances in other cognitive phenotypes, 35,37–39 we also conducted a Y‐maze test to further confirm the neuroprotective effects of KOR antagonist (Figure 7A,B). We found that METH decreased number (Figure 7E, F (2, 33) = 6.921, p = 0.0031) and rate of spontaneous alteration (SAP) (Figure 7F, F (2, 33) = 13.33, p < 0.0001) and increased incorrect same arms returns (SAR) (Figure 7D, F ((2, 33) = 4.995, p = 0.0127), which was reserved by norBNI microinjections into PL before METH treatment.…”

Section: Resultsmentioning

confidence: 99%

“…Since METH exposure can also lead to poor performances in other cognitive phenotypes, 35,[37][38][39] we also conducted a Y-maze test to further confirm the neuroprotective effects of KOR antagonist (Figure 7A,B). We found that METH decreased number (Figure 7E, F The medial prefrontal cortex (mPFC) is a crucial brain region involved in cognition.…”

Section: Intra-pl But Not Il Injection Of Kor Antagonist Prevents Met...mentioning

confidence: 99%

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Prelimbic cortex dynorphin/κ opioid receptor system modulates methamphetamine‐induced cognitive impairment

Cheng,

Deng,

Deng

et al. 2023

Addiction Biology

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Chronic exposure to methamphetamine (METH) causes severe and persistent cognitive impairment. The present study aimed to investigate the role of dynorphin/κ opioid receptor (KOR) system in the development of METH‐induced cognitive impairment. We found that mice showed significant cognitive impairment in the novel object recognition test (NOR) following daily injections of METH (10 mg/kg) for seven consecutive days. Systemic blockade of KOR prevented METH‐induced cognitive impairment by pretreatment of the selective KOR antagonist norBNI (10 mg/kg, i.p.) or KOR deletion. Then, significant increased dynorphin and KOR mRNA were observed exclusively in prelimbic cortex (PL) other than infralimbic cortex. Finally, microinjection with norBNI into PL also improved cognitive memory in METH‐treated mice using NOR and spontaneous alternation behaviour test. Our results demonstrated that dynorphin/KOR system activation in PL may be a possible mechanism for METH‐induced cognitive impairment and shed light on KOR antagonists as a potential neuroprotective agent against the cognitive deficits induced by drug abuse.

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Section: Resultsmentioning

confidence: 99%

Section: Intra-pl But Not Il Injection Of Kor Antagonist Prevents Met...mentioning

confidence: 99%

Prelimbic cortex dynorphin/κ opioid receptor system modulates methamphetamine‐induced cognitive impairment

Cheng,

Deng,

Deng

et al. 2023

Addiction Biology

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“…As reported in Table 1 , it seems that NOR memory is affected by MA administration through diverse pathophysiological mechanisms, 28 , 52 , 53 and looking at the mechanisms of this alteration needs consideration of different molecular pathways, though the use of the NOR paradigm is extremely helpful in elucidating the neurobiological consequences of MA administration and also the cognitive dysfunctions associated with long term use of psychostimulants including MA. It consider that the main mechanism of recognition memory deficit is the alternation in the monoaminergic system.…”

Section: Discussionmentioning

confidence: 99%

A Review on the Disruption of Novel Object Recognition Induced by Methamphetamine

Seyedhosseini Tamijani,

Beirami,

Ghazvini

et al. 2023

Addict Health

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Background: Methamphetamine (MA), is a widely abused synthetic psychostimulant that leads to irreversible brain damage manifested as cognitive impairments in humans and animals. The novel object recognition (NOR) task is a commonly used behavioral assay for the investigation of non-spatial memory in rodents. This test is based on the natural tendency of rodents to spend more time exploring a novel object than a familiar one. NOR test has been used in many studies investigating cognitive deficits caused by MA in rodents. The objective of the present study was to review neurobiological mechanisms that might be responsible for MA-induced NOR alterations. Methods: A PubMed search showed 83 publications using novel object recognition and methamphetamine as keywords in the past 10 years. Findings: The present study revealed different MA regimens cause recognition memory impairment in rodents. In addition, it was found that the main neurobiological mechanism involved in MA-induced recognition deficits is the dysfunction of monoaminergic systems. Conclusion: NOR is a useful test to assess the cognitive functions following MA administration and evaluate the efficacy of new therapeutic agents in MA-addicted individuals.

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The role of heterodimers formed by histamine H3 receptors and dopamine D1 receptors on the methamphetamine-induced conditioned place preference

Fan,

Gong,

et al. 2024

European Journal of Pharmacology

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Neuroprotective effect of histamine H3 receptor blockade on methamphetamine-induced cognitive impairment in mice

Cited by 5 publications

References 57 publications

Prelimbic cortex dynorphin/κ opioid receptor system modulates methamphetamine‐induced cognitive impairment

Prelimbic cortex dynorphin/κ opioid receptor system modulates methamphetamine‐induced cognitive impairment

A Review on the Disruption of Novel Object Recognition Induced by Methamphetamine

The role of heterodimers formed by histamine H3 receptors and dopamine D1 receptors on the methamphetamine-induced conditioned place preference

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