Neuroprotective effect of Hongjing I granules on erectile dysfunction in a rat model of bilateral cavernous nerve injury

Ma, Ke; Zhao, Fan; Ye, Miaoyong; Zhou, Kang; Huang, Wenjie; Zhao, Jianfeng; Ma, Yan; Shou, Qiyang; Lv, Bodong

doi:10.1016/j.biopha.2020.110405

Cited by 10 publications

(7 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The administration of Hongjing I granules (a new herbal formula derived from traditional Chinese medicine) improved ED in CNI rats dose‐dependent. Furthermore, this herbal treatment increased nNOS expression, Schwann cells viability and promoted neurites regeneration of major pelvic ganglia 207 …”

Section: Introductionmentioning

confidence: 89%

“…Furthermore, this herbal treatment increased nNOS expression, Schwann cells viability and promoted neurites regeneration of major pelvic ganglia. 207 The data mentioned above suggest that several herbal components may protect the peripheral nerve from damage. Also, these alternative natural approaches might protect the cavernosal nerve against crush injury through stimulating the release of neurotrophic factors, increasing neuronal survival, and preserving the nNOS, nerve fibers, and contents of the penile CC.…”

Section: Galaninmentioning

confidence: 99%

See 1 more Smart Citation

An update on the current status and future prospects of erectile dysfunction following radical prostatectomy

Asker

Yilmaz‐Oral

Öztekin³

et al. 2022

The Prostate

View full text Add to dashboard Cite

Background: Radical prostatectomy (RP) and radiation treatment are standard options for localized prostate cancer. Even though nerve-sparing techniques have been increasingly utilized in RP, erectile dysfunction (ED) due to neuropraxia remains a frequent complication. Erectile function recovery rates after RP remain unsatisfactory, and many men still suffer despite the availability of various therapies. Objective: This systematic review aims to summarize the current treatments for post-RP-ED, assess the underlying pathological mechanisms, and emphasize promising therapeutic strategies based on the evidence from basic research. Method: Evaluation and review of articles on the relevant topic published between 2010 and 2021, which are indexed and listed in the PubMed database. Results: Phosphodiesterase type 5 inhibitors, intracavernosal and intraurethral injections, vacuum erection devices, pelvic muscle training, and surgical procedures are utilized for penile rehabilitation. Clinical trials evaluating the efficacy of erectogenic drugs in this setting are conflicting and far from being conclusive. The use of androgen deprivation therapy in certain scenarios after RP further exacerbates the already problematic situation and emphasizes the need for effective treatment strategies. Conclusion: This article is a detailed overview focusing on the pathophysiology and mechanism of the nerve injury developed during RP and a compilation of various strategies to induce cavernous nerve regeneration to improve erectile function (EF). These strategies include stem cell therapy, gene therapy, growth factors, lowintensity extracorporeal shockwave therapy, immunophilins, and various pharmacological approaches that have induced improvements in EF in experimental models of cavernous nerve injury. Many of the mentioned strategies can improve EF following RP if transformed into clinically applicable safe, and effective techniques with reproducible outcomes.

show abstract

Section: Introductionmentioning

confidence: 89%

Section: Galaninmentioning

confidence: 99%

An update on the current status and future prospects of erectile dysfunction following radical prostatectomy

Asker

Yilmaz‐Oral

Öztekin³

et al. 2022

The Prostate

View full text Add to dashboard Cite

show abstract

“…A 25 G metal needle was inserted and connected to a PE50 catheter filled with heparin sodium normal saline. The catheter was connected to a MP160 pressure transducer (Biopac Systems, Inc.) to measure the internal pressure of the cavernous body (Ma et al., 2020). The cavernous nerve was stimulated with a bipolar electric hook, and ICP was recorded.…”

Section: Methodsmentioning

confidence: 99%

Application of laser speckle blood perfusion imaging in the evaluation of erectile function in rats

Zhou

et al. 2021

Andrologia

Self Cite

View full text Add to dashboard Cite

show abstract

“…42 Ma et al confirmed that nNOS was significantly down-regulated in the penile tissues of BCNI rats, accompanied by an increase in TH, which is similar to our results obtained by western blot and immunofluorescence staining. 43 However, ALCAR can promote the level of nNOS in the corpus cavernosum, inhibit the expression of TH, and improve the erectile function of BCNI rats.…”

Section: Radical Prostatectomy (Rp) Is One Of the Most Used Treatmentsmentioning

confidence: 99%

Acetyl‐L‐carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration

Wang

Song

et al. 2022

Andrology

View full text Add to dashboard Cite

Background: Neurogenic erectile dysfunction (NED) caused by cavernous nerve (CN) injury is a typical complication after pelvic surgery, which lacks efficient treatments.Acetyl-L-carnitine (ALCAR) has been proven to promote nerve repair. Objectives:To investigate the effect and potential mechanism of ALCAR in the treatment of NED.Materials and methods: Thirty-two rats were randomly divided into bilateral CN injury (BCNI) group, BCNI + lower-dose ALCAR (50 mg/kg/day) group, BCNI + higher-dose (100 mg/kg/day) group, and sham-operated group. Erectile function was assessed 14 days after daily intraperitoneal injection of ALCAR or placebo. The penile tissues were gathered for subsequent histological and molecular biological analysis. Rat Schwann cell (SC) line S16 was used to verify the mechanism of ALCAR in vitro. Results:We found that the erectile function of the rats in the BCNI group was severely impaired, which was improved considerably in both BCNI+ALCAR-LD and BCNI+ALCAR-HD groups. Also, we observed decreased smooth muscle and increased collagen content in the corpus cavernosum in the BCNI group. The expressions of fibrosis markers transforming growth factor-beta (TGF-β), connective tissue growth factor (CTGF), and Smad 2/3 were significantly up-regulated in the BCNI group. The above changes were alleviated after the administration of lower and higher-dose ALCAR.Meanwhile, the nitric oxide (NO)/cyclic guanosine monophosphate pathway (cGMP) was promoted and the Ras homolog gene family member A (RhoA)/Rho-associated protein kinase (ROCK) pathway was inhibited in the corpus cavernosum of BCNI rats after ALCAR treatment, accompanied by increased neuronal nitric oxide synthase (nNOS) and down-regulated tyrosine hydroxylase (TH). In vitro, ALCAR promoted the migration and proliferation of SC and increased the expression of 22-kD peripheral

show abstract

Neuroprotective effect of Hongjing I granules on erectile dysfunction in a rat model of bilateral cavernous nerve injury

Cited by 10 publications

References 46 publications

An update on the current status and future prospects of erectile dysfunction following radical prostatectomy

An update on the current status and future prospects of erectile dysfunction following radical prostatectomy

Application of laser speckle blood perfusion imaging in the evaluation of erectile function in rats

Acetyl‐L‐carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration

Contact Info

Product

Resources

About