2011
DOI: 10.3389/fneur.2011.00023
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Neuroprotective Effect of Hyperbaric Oxygen Therapy on Anterior Ischemic Optic Neuropathy

Abstract: The study investigated the therapeutic effect of hyperbaric oxygen (HBO) on anterior ischemic optic neuropathy in a rodent model (rAION). rAION was laser-induced in one eye of 63 mice. The fellow (uninjured) eye served as an internal control. Thirty-three mice underwent two 90-min sessions of 100% oxygen (2 atm) treatment immediately following injury and one session daily thereafter for up to 14 days. The remaining mice were untreated. Retinas were harvested at different time points, and mRNA levels of various… Show more

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Cited by 15 publications
(15 citation statements)
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“…After removal of the filament and wound closure, animals receiving HBOT were placed in a chamber containing 100% oxygen at 2.5 atmospheres pressure for 60 minutes, as previously reported [11], without receiving further anesthesia. The time between filament removal and achieving 2.5 atmospheres 100% oxygen was approximately 10 minutes.…”
Section: Induction Of Middle Cerebral Artery Occlusionmentioning
confidence: 99%
“…After removal of the filament and wound closure, animals receiving HBOT were placed in a chamber containing 100% oxygen at 2.5 atmospheres pressure for 60 minutes, as previously reported [11], without receiving further anesthesia. The time between filament removal and achieving 2.5 atmospheres 100% oxygen was approximately 10 minutes.…”
Section: Induction Of Middle Cerebral Artery Occlusionmentioning
confidence: 99%
“…[9][10][11][12][13][14][15] In addition, there have been a number of studies searching for the effect of hyperbaric oxygen on radiation induced optic neuropathy 16,17 and ischemic optic neuropathy. 18,19 Kihara 20 showed a positive effect to of HBO on experimental ischemic neuropathy. Only a few studies have addressed the effect of hyperbaric oxygen on other types of neuropathy.…”
Section: Introductionmentioning
confidence: 95%
“…There is evidence from multiple investigators to support a positive effect of HBO in accelerating recovery after traumatic nerve injury . In addition, there have been a number of studies searching for the effect of hyperbaric oxygen on radiation induced optic neuropathy and ischemic optic neuropathy . Kihara showed a positive effect to of HBO on experimental ischemic neuropathy.…”
Section: Introductionmentioning
confidence: 99%
“…Rodent models of AION (rAION) have so far proved invaluable for testing potential novel treatments. Hyperbaric oxygen administered during the critical period immediately after induction of injury proved effective in preventing RGC loss ( 50 ). Intravenous or intravitreous prostaglandin J2 proffered almost equal protection when administered 5 h before rAION injury or immediately after, suggesting that it may have an even longer therapeutic window in humans in whom the injury develops more slowly, with episodes of recurring ONH edema ( 51 , 52 ).…”
Section: Animal Models Of Na-aion: the Future Targets Of Medical Treamentioning
confidence: 99%