Neuroprotective effect of melatonin in a rat model of streptozotocin-induced diabetic neuropathy

Afifi, Noha M.

doi:10.1097/01.ehx.0000428963.44300.63

Cited by 12 publications

(12 citation statements)

References 26 publications

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“…In the sciatic nerves, melatonin has been reported to reduce vacuolization of the myelin sheath, axon-myelin separation and the number of degenerated fibers. In cerebral cortices, melatonin-treated diabetic rats showed the reduction in the neurodegenerative and necrotic changes; spongiosis and reactive astrogliosis were absent and scattered pyknotic neurons with perineural vacuolations and swollen neurons with karolysis were remarkably reduced in animals with cerebral diabetic neuropathy [156,157].…”

Section: Therapeutic Potentials Of Melatonin For Diabetic Neuropathymentioning

confidence: 99%

Melatonin: new insights on its therapeutic properties in diabetic complications

Pourhanifeh

Hosseinzadeh

Dehdashtian

et al. 2020

Diabetol Metab Syndr

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Diabetes and diabetic complications are considered as leading causes of both morbidity and mortality in the world. Unfortunately, routine medical treatments used for affected patients possess undesirable side effects, including kidney and liver damages as well as gastrointestinal adverse reactions. Therefore, exploring the novel therapeutic strategies for diabetic patients is a crucial issue. It has been recently shown that melatonin, as main product of the pineal gland, despite its various pharmacological features including anticancer, anti-aging, antioxidant and antiinflammatory effects, exerts anti-diabetic properties through regulating various cellular mechanisms. The aim of the present review is to describe potential roles of melatonin in the treatment of diabetes and its complications.

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Section: Therapeutic Potentials Of Melatonin For Diabetic Neuropathymentioning

confidence: 99%

Melatonin: new insights on its therapeutic properties in diabetic complications

Pourhanifeh

Hosseinzadeh

Dehdashtian

et al. 2020

Diabetol Metab Syndr

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“…Based on these mechanisms of injury, various prevention and treatment strategies have been already suggested and are under investigation. For instance, the effects of several antioxidants such as vitamin E [ 7 ], melatonin [ 8 ] and date extract [ 1 ], fatty acid contained diets like Omega 3 [ 9 ], aldose reductase inhibitors [ 10 ] and also statins compounds such as atorvastatin [ 11 ] have been investigated.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices

Zangiabadi

Mohtashami

Hojatipour

et al. 2014

The Scientific World Journal

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Diabetes mellitus is the most common metabolic disease with a high prevalence rate in human society that eventually leads to the peripheral nervous system complications in a great number of patients. In the present study, the effects of Angipars on nerve conduction velocity, histological alterations, and behavioral indices were investigated. Diabetes was induced in male rats by intraperitoneal injection of streptozotocin (STZ). Six weeks after STZ injection, animals were divided into five groups control, vehicle, and 3 experimental groups. The vehicle group received 1 mL distilled water daily for two weeks and three experimental groups received, respectively, intraperitoneal injection of 5, 10, and 20 mg/kg Angipars daily for two weeks. Intraperitoneal injection of Angipars, in some extent, could significantly improve behavioral indices of the experimental groups as compared to the vehicle group. Furthermore, mean nerve conduction velocity in the vehicle group showed significant difference with that in the control and the 2nd experimental groups; therefore, Angipars could increase nerve conduction velocity in neuropathic rats. Overall, Angipars exerted positive effects on the treatment and reduction of physiologic symptoms and improvement of sciatic morphological injuries in neuropathic rats.

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“…24 During his study on STZ-induced diabetes in rats, Afifi, observed marked axonal atrophy in sciatic nerve fibers along with axonal shrinkage and sometimes total axonal destruction. 25 They observed a significant decrease in sciatic nerve fibers in the diabetic rats compared with the control. These findings were in agreement with the histopathological findings observed in this study.…”

Section: Figure (2)mentioning

confidence: 94%

Arabic gum acacia improves diabetic peripheral neuropathy in rats: a biochemical and histopathological evidence

Almohaimeed

Amin

El-Aziz

et al. 2018

Int J Basic Clin Pharmacol

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INTRODUCTIONDiabetes mellitus (DM) is thought to be a noteworthy risk to public health. Data from the World Health Organization (WHO) showed that almost half of all deaths attributable to high blood glucose occur before the age of 70 years. WHO projects that diabetes will be the seventh leading cause of death in 2030. 1 Diabetic peripheral neuropathy (DPN) is a frequent complication of diabetes mellitus.Studies conducted in the Middle East revealed high rates of DPN ranged from 35% to 65%. The DPN is more frequently represented than other complications of Diabetes Mellitus. It was reported that it is responsible for 50%-75% of non-traumatic amputations. Painful DPN has high grade of functional disability which influences health-related quality of life. 2 Hyperglycemia is basic for occurrence and advancement of DPN with the etiological hypotheses on metabolic or vascular causes. 3 Regardless of numerous investigations on DPN, the present ABSTRACT Background: Diabetic peripheral neuropathy (DPN) is a frequent complication of diabetes mellitus and unfortunately, its present therapeutic alternatives are exceptionally poor. Objectives of this study was to assess the antidiabetic, antioxidant and hypolipidemic action of Gum Arabic (GA) and its role in promoting the functional recovery from diabetic neuropathy developed in in an experimental model of diabetic neuropathy. Methods: Sixty adult male Sprague-Dawley rats were utilized and randomly assigned into six groups (n= 10); control, Arabic gum-treated, untreated diabetic, diabetic received metformin, diabetic received metformin and B12 vitamin and diabetic received metformin, B12 vitamin and AG. Locomotor activity and hyperalgesia were assed at the end of the study. Fasting and two hours postprandial blood glucose, serum insulin levels, lipid Profile, oxidants/antioxidants parameters were assessed in the blood. Sciatic nerve was assessed histopathologically. Results: The locomotor activity of the untreated diabetic rats was significantly (p<0.001) reduced compared to the control group while it was significantly increased in all treated groups. The lipid profile and Malondialdehyde were significantly improved in all treated groups. Levels of CAT, GSH, SOD, GPx were significantly decreased in untreated diabetic group compared to the control while they were significantly increased in all treated groups compared to the untreated diabetic group. Sciatic nerve fibers of untreated diabetic rats showed degenerated axons with dilated myelin sheaths and degenerated Schwann cells. The nerve had significantly fewer fiber compared to the control. These changes were alleviated in all the treated groups specifically that received metformin, vitamin B12 and GA. Conclusions: It could be concluded that Arabic gum had hypoglycemic, antioxidant and hypolipidemic activity and had a protective effect on diabetic neuropathy. Based on this it is recommended that human clinical trials are necessary to prove this therapeutic effect.

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Neuroprotective effect of melatonin in a rat model of streptozotocin-induced diabetic neuropathy

Cited by 12 publications

References 26 publications

Melatonin: new insights on its therapeutic properties in diabetic complications

Melatonin: new insights on its therapeutic properties in diabetic complications

The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices

Arabic gum acacia improves diabetic peripheral neuropathy in rats: a biochemical and histopathological evidence

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