Neuroprotective Effect of Methanolic Extract of Sargassum Wightii on Haloperidol Induced Catalepsy and Tardive Dyskinesia in Albino Rats

Introduction: The pathogenesis of Parkinson’s disease (PD) is multifactorial in which oxidative stress, neuroinflammation, and mitochondrial dysfunction are the leading factors. Currently, the antioxidant and anti-inflammatory agents of natural sources as neuroprotectants have raised much attention. The current study aimed to explore the neuroprotective effect of methanolic extract of Sargassum wightii in male Wistar albino rats against rotenone-induced PD. Methods: The rats were administered with rotenone (10 mg/kg orally) daily for 28 days to induce PD. S. wightii (200 mg/kg and 400 mg/kg) and levodopa+carbidopa combination (10 mg/kg) were administered to different groups of rats one hour prior to rotenone for 28 days. Behavioral parameters (akinesia, tremor, motor coordination, and locomotor activities) and body weight were recorded on days 14th and 28th of drug treatment. On the 28th day, the animals were sacrificed for the neurobiochemical analyses of brain tissue. Results: Rotenone treatment caused a significant reduction in behavioural parameters (P < 0.001), neurochemical deficits (P < 0.001), and elevation of oxidative stress markers (P < 0.001) in the brain. Pre-treatment with S. wightii at 200 mg/kg and 400 mg/kg doses significantly attenuated the rotenone-induced behavioral alterations and restored the mitochondrial NADH dehydrogenase activity and dopamine level in the striatum (P < 0.001). Moreover, 400 mg/kg of S. wightii restored the rotenone-induced increased oxidative stress markers like malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH) in the striatum (P < 0.01). Conclusion: S. wightii has provided a neuroprotective effect, probably by virtue of its antioxidant and dopamine restoring potential. Hence, it may offer a promising and new therapeutic lead for the treatment of PD but needs further research.

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“…The animals were observed for 24 hours. No mortality or behavioral changes were observed during the study period (16).…”

Section: Acute Toxicity Testmentioning

confidence: 92%

“…The methanolic extract of S. wightii was subjected to a phytochemical screening test in our earlier study and was found to contain polyphenols, terpenoids, tannins, flavonoids, and polysaccharides (16).…”

Section: Phytochemical Screening Of Plant Extractmentioning

confidence: 99%

Neuroprotective effect of methanolic extract of Sargassum wightii on rotenone-induced parkinsonism-like symptoms in Wistar albino rats

Rout

Rath

Bhattamisra

et al. 2021

J Herbmed Pharmacol

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“…of 1 for each paw was added to the scores of steps I and II. Thus, the highest score for any animal was 3.5 (cut off score) and that reflects total catalepsy [31,32].…”

Section: Bala and Abidmentioning

confidence: 99%

Neuroprotective Effect of Hydroalcoholic Extract of Amaranthus Tricolor Leaves on Experimental Animals

Bala

Abid

2020

Asian J Pharm Clin Res

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Objective: The research work deals with the screening of hydroalcoholic extract of Amaranthus tricolor (HAEATL) leaves for central nervous system activity (anti-stress, nootropic, and anti-cataleptic activity). Methods: The screening of scopolamine and different model-induced neurodisorder rats were treated with 200 and 400 mg/kg body weight dose of hydroalcoholic extract of A. tricolor lives in 7 days’ experimental schedule. It has been reported that the antioxidant, hepatoprotective, hematological, and antimicrobial activities. Results: The result of the study reflected that HAEATL (200 and 400 mg/kg) was effective in all methods and showed anti-stress, nootropic, and anti-cataleptic activity in a dose-dependent manner. The results are represented that the HAEATL produce the significant decreased the swimming time, increased the anoxia time, decreased level of biochemical parameters such as glucose and cholesterol except blood urea nitrogen, decreased level of white blood cell and red blood cell, and more significantly decreased the catalepsies score on 7th day compared to the control group. Conclusion: The above valuable animal study, we concluded that the HAEATL showing significantly affect compeer to the disease control group on neuroprotective activity.

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“…Polyphenolic compounds like flavonoids present in marine macro algae being potent antioxidants. The antioxidant, anti-inflammatory and neuroprotective effects of Sargassum wightii were well established [7,8]. But there is paucity of data regarding neuroprotective effect of Sargassum wightii especially of Indian coasts origin.…”

Section: Introductionmentioning

confidence: 99%

Effects of Sargassum wightii Methanolic Extract on L-Methionine Induced Experimental Vascular Dementia like Syndrome in Albino Wistar Rats

Rout

Rath

Bhattamisra

et al. 2021

JPRI

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Sargassum wightii is brown seaweeds with high nutritive value with natural bioactive compounds having diverse therapeutic activity. In recent years, research on Sargassum wightii has gain much interest in neuropharmacological field. Basing on neuroprotective effect of Sargassum wightii against Parkinson’s disease animal models, the possible protective effect on dementia is hypothesised. Addressing this question the present study was designed to investigate the effect of S. wightii on L-methionine induced vascular dementia like syndrome in male wistar albino rats. Vascular dementia was induced by oral administration of L-methionine (1.7 g/kg) per body weight for 4weeks S. wightii was given from day1 to day32. The neurobehavioral assessment was performed by Morris water maze test for learning and memory ability and blood sample was collected for serum nitrite and homocysteine analysis. The whole brain content was subjected to a series of biochemical analysis that included brain cholinesterase, malondialdehyde, reduced glutathione and histopathological examination. L-methionine impaired learning and memory, increased serum homocysteine and decreased serum nitrite level significantly (p<0.001). It also increased brain thiobarbituric acid reactive substances, reduced glutathione and increased acetylcholinesterase activity significantly (p<0.001). Sargassum wightii at 200mg/kg and 400mg/kg body weight reversed the L-methionine induced learning and memory deficits (p<0.01) and (p<0.001) respectively. The L-methionine induced biochemical alterations in serum and brain as well as histopathological aberration in cortex and hippocampus were restored by Sargassum wightii (p<0.01). This study concluded that Sargassum wightii ameliorated L-methionine induced vascular dementia like syndrome and provided a new concept in anti-dementia therapy as a neuroprotectants.

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Neuroprotective Effect of Methanolic Extract of Sargassum Wightii on Haloperidol Induced Catalepsy and Tardive Dyskinesia in Albino Rats

Cited by 7 publications

References 26 publications

Neuroprotective effect of methanolic extract of Sargassum wightii on rotenone-induced parkinsonism-like symptoms in Wistar albino rats

Neuroprotective effect of methanolic extract of Sargassum wightii on rotenone-induced parkinsonism-like symptoms in Wistar albino rats

Neuroprotective Effect of Hydroalcoholic Extract of Amaranthus Tricolor Leaves on Experimental Animals

Effects of Sargassum wightii Methanolic Extract on L-Methionine Induced Experimental Vascular Dementia like Syndrome in Albino Wistar Rats

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