Neuroprotective effect of plasmalogens on AlCl3-induced Alzheimer's disease zebrafish via acting on the regulatory network of ferroptosis, apoptosis and synaptic neurotransmission release with oxidative stress as the center

Zhang, Jian; Guo, Shunyuan; Tao, Rong; Wang, Fan; Xie, Yihong; Wang, Huizi; Ding, Lan; Shen, Yuejian; Zhou, Xiaoli; Feng, Junli; Shen, Qing

doi:10.1016/j.neulet.2023.137560

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…This damage to membrane function has stimulated research into the protective effects of antioxidants on membranes. Different endogenous and exogenous molecules can efficiently protect against LP: enzymes, vitamin E, cholesterol, plasmalogens, and polyphenols. − Food-borne plant polyphenols (FPPs) are one of the most efficient compounds among exogenous antioxidants against oxidative stress. FPPs, naturally occurring in foods such as fruits, vegetables, and tea, are increasingly recommended as daily supplements. − The intake of a certain amount of FPPs has a positive effect on the growth and development of the organism and may inhibit the onset and progression of diseases.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Zhang,

Liu,

et al. 2024

J. Agric. Food Chem.

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Lipid peroxidation (LP) leads to changes in the fluidity and permeability of cell membranes, affecting normal cellular function and potentially triggering apoptosis or necrosis. This process is closely correlated with the onset of many diseases. Evidence suggests that the phenolic hydroxyl groups in food-borne plant polyphenols (FPPs) make them effective antioxidants capable of preventing diseases triggered by cell membrane LP. Proper dietary intake of FPPs can attenuate cellular oxidative stress, especially damage to cell membrane phospholipids, by activating the Nrf2/GPx4 pathway. Nuclear factor E2-related factor 2 (Nrf2) is an oxidative stress antagonist. The signaling pathway regulated by Nrf2 is a defense transduction pathway of the organism against external stimuli such as reactive oxygen species and exogenous chemicals. Glutathione peroxidase 4 (GPx4), under the regulation of Nrf2, is the only enzyme that reduces cell membrane lipid peroxides with specificity, thus playing a pivotal role in regulating cellular ferroptosis and counteracting oxidative stress. This study explored the Nrf2/GPx4 pathway mechanism, antioxidant activity of FPPs, and mechanism of LP. It also highlighted the bioprotective properties of FPPs against LP and its associated mechanisms, including (i) activation of the Nrf2/GPx4 pathway, with GPx4 potentially serving as a central target protein, (ii) regulation of antioxidant enzyme activities, leading to a reduction in the production of ROS and other peroxides, and (iii) antioxidant effects on LP and downstream phospholipid structure. In conclusion, FPPs play a crucial role as natural antioxidants in preventing LP. However, further in-depth analysis of FPPs coregulation of multiple signaling pathways is required, and the combined effects of these mechanisms need further evaluation in experimental models. Human trials could provide valuable insights into new directions for research and application.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Zhang,

Liu,

et al. 2024

J. Agric. Food Chem.

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Role of miRNA regulation in IGFBP-2 overexpression and neuronal ferroptosis: Insights into the Nrf2/SLC7A11/GPX4 pathway in Alzheimer's disease

Luo,

Wu,

Xiao

et al. 2025

International Journal of Biological Macromolecules

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Introduction to Alzheimer's Disease, Biomarkers, and the AI Revolution

Yingngam

2024

Advances in Medical Technologies and Clinical Practice

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Alzheimer's disease (AD) is a progressive neurodegenerative disease that results in a steady decline in cognitive ability and memory function. As society ages, the need for an optimum AD management strategy becomes more important. This chapter analyzes the stage-construction etiology and escalating symptoms of AD discovered throughout this review, as well as the identification of the barrier to precise diagnosis. The ability of artificial intelligence to achieve more precise and quicker detection through machine learning, data analytics, and predictive modeling is also being considered. Therefore, employing AI in AD-related studies is a novel approach to enhancing patient outcomes. Proper diagnosis of the parallel increased probability of many parameters is one of the most difficult AD moments to identify. However, the use of artificial intelligence evaluation sensor network technologies and big data analysis has advanced, and preventive instruments can be used. Thus, technology gives humanity hope to stop or, at the very least, slow down this tragedy.

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Neuroprotective effect of plasmalogens on AlCl3-induced Alzheimer's disease zebrafish via acting on the regulatory network of ferroptosis, apoptosis and synaptic neurotransmission release with oxidative stress as the center

Cited by 3 publications

References 32 publications

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Role of miRNA regulation in IGFBP-2 overexpression and neuronal ferroptosis: Insights into the Nrf2/SLC7A11/GPX4 pathway in Alzheimer's disease

Introduction to Alzheimer's Disease, Biomarkers, and the AI Revolution

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