Neuroprotective effect of quercetin nanoparticles: A possible prophylactic and therapeutic role in alzheimer’s disease

Rifaai, Rehab Ahmed; Mokhemer, Sahar Ahmed; Saber, Entesar Ali; El-Aleem, Seham A Abd; El‐Tahawy, Nashwa Fathy Gamal

doi:10.1016/j.jchemneu.2020.101795

Cited by 66 publications

(34 citation statements)

References 93 publications

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“…Recently, quercetin was subjected to a clinical trial to evaluate its effect on improving the cerebral blood flow in the aged population ( NCT01376011 ). However, it was found that quercetin possessed low oral bioavailability (<2%) and weak BBB permeability, limiting its pharmacological application in ischemic stroke [ 188 ]. Rutin (quercetin-3-rhamnosyl glucoside), a glycoside of quercetin, abundantly exists in buckwheat, passionflower, and apple.…”

Section: Phytochemicals That Exert Neuroprotection In Experimental Ischemic Strokementioning

confidence: 99%

Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications

Wang

Chen

et al. 2021

Oxidative Medicine and Cellular Longevity

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Ischemic stroke is a challenging disease with high mortality and disability rates, causing a great economic and social burden worldwide. During ischemic stroke, ionic imbalance and excitotoxicity, oxidative stress, and inflammation are developed in a relatively certain order, which then activate the cell death pathways directly or indirectly via the promotion of organelle dysfunction. Neuroprotection, a therapy that is aimed at inhibiting this damaging cascade, is therefore an important therapeutic strategy for ischemic stroke. Notably, phytochemicals showed great neuroprotective potential in preclinical research via various strategies including modulation of calcium levels and antiexcitotoxicity, antioxidation, anti-inflammation and BBB protection, mitochondrial protection and antiapoptosis, autophagy/mitophagy regulation, and regulation of neurotrophin release. In this review, we summarize the research works that report the neuroprotective activity of phytochemicals in the past 10 years and discuss the neuroprotective mechanisms and potential clinical applications of 148 phytochemicals that belong to the categories of flavonoids, stilbenoids, other phenols, terpenoids, and alkaloids. Among them, scutellarin, pinocembrin, puerarin, hydroxysafflor yellow A, salvianolic acids, rosmarinic acid, borneol, bilobalide, ginkgolides, ginsenoside Rd, and vinpocetine show great potential in clinical ischemic stroke treatment. This review will serve as a powerful reference for the screening of phytochemicals with potential clinical applications in ischemic stroke or the synthesis of new neuroprotective agents that take phytochemicals as leading compounds.

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Section: Phytochemicals That Exert Neuroprotection In Experimental Ischemic Strokementioning

confidence: 99%

Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications

Wang

Chen

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…However, quercetin is a well-known flavonoid with low bioavailability. Recently, quercetin nanoparticles have been shown to have a better bioavailability [86]. In 6-week-old male albino Sprague-Dawley rats, pre-irradiation oral administration of Rutin with 200 mg/kg b.w/day for 21 days provided neuroprotection against γ-radiation-induced neurotoxicity via activation of the phosphatidylinositol-3-kinase (PI3K)/serine-threonin protein kinase (AKT)/ glycogen synthase kinase 3 β (GSK3β)/ nuclear factor erythroid-2 related factor-2 (NRF-2) pathway by altering the phosphorylation state through its ability to scavenge free radicals generation, modulating gene expression, and its anti-inflammatory effects when animals were γ-irradiated with 5 Gy [87].…”

Section: Radio-neuro-protective Roles Of Flavonoidsmentioning

confidence: 99%

Radioprotective Effect of Flavonoids on Ionizing Radiation-Induced Brain Damage

Wang

Xie

et al. 2020

Molecules

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Patients receiving brain radiotherapy may suffer acute or chronic side effects. Ionizing radiation induces the production of intracellular reactive oxygen species and pro-inflammatory cytokines in the central nervous system, leading to brain damage. Complementary Chinese herbal medicine therapy may reduce radiotherapy-induced side effects. Flavonoids are a class of natural products which can be extracted from Chinese herbal medicine and have been shown to have neuroprotective and radioprotective properties. Flavonoids are effective antioxidants and can also inhibit regulatory enzymes or transcription factors important for controlling inflammatory mediators, affect oxidative stress through DNA interactions and enhance genomic stability. In this paper, radiation-induced brain damage and the relevant molecular mechanism were summarized. The radio-neuro-protective effect of flavonoids, i.e., antioxidant, anti-inflammatory and maintaining genomic stability, were then reviewed. We concluded that flavonoids treatment may be a promising complementary therapy to prevent radiotherapy-induced brain pathophysiological changes and cognitive impairment.

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“…A constant dose of quercetin nanoparticles was administrated to animals along with AlCl 3 . Based on microscopic results, nanoparticles showed neurogenerative changes and improvement of tyrosine hydroxylase (TH), and this study was the first study revealing the therapeutic effects of quercetin nanoparticles for Alzheimer's disease (AD) model and further investigation was warned by Rifaai et al [85]. Neuroprotection against cerebral ischemia/reperfusion injury in rats was studied by Wang et al [86] using quercetin oral pretreatment.…”

Section: Quercetin As a Neuroprotective Agentmentioning

confidence: 95%

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Bhat

2021

Biology

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Quercetin, a bioactive secondary metabolite, holds incredible importance in terms of bioactivities, which has been proved by in vivo and in vitro studies. The treatment of cardiovascular and neurological diseases by quercetin has been extensively investigated over the past decade. Quercetin is present naturally in appreciable amounts in fresh produce (fruits and vegetables). However, today, corresponding to the growing population and global demand for fresh fruits and vegetables, a paradigm shift and focus is laid towards exploring industrial food wastes and/or byproducts as a new resource to obtain bioactive compounds such as quercetin. Based on the available research reports over the last decade, quercetin has been suggested as a reliable therapeutic candidate for either treating or alleviating health issues, mainly those of cardiovascular and neurological diseases. In the present review, we have summarized some of the critical findings and hypotheses of quercetin from the available databases foreseeing its future use as a potential therapeutic agent to treat cardiovascular and neurological diseases. It is anticipated that this review will be a potential reference material for future research activities to be undertaken on quercetin obtained from fresh produce as well as their respective processing wastes/byproducts that rely on the circular concept.

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Neuroprotective effect of quercetin nanoparticles: A possible prophylactic and therapeutic role in alzheimer’s disease

Cited by 66 publications

References 93 publications

Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications

Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications

Radioprotective Effect of Flavonoids on Ionizing Radiation-Induced Brain Damage

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

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