Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats

Red wine but not ethanol at low doses can protect against the toxicity of methamphetamine

“…Red wine contains a large range of polyphenolic and flavonoid compounds (Croft, 1998;Sun et al, 2002) and it remains to be determined whether the protective agent is related to resveratrol. Resveratrol can attenuate the effect of acute MPTP treatment, in depleting dopamine and its metabolites (Blanchet et al, 2008) and can retard the development of Parkinsonian symptoms following administration of 6-hydroxydopamine (Jin et al, 2008). Direct comparison with our findings is difficult since the study of Blanchet employed doses of resveratrol several order of magnitude greater that those found in red wine.…”

Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice

“…Indeed, potent therapeutic effects of resveratrol administration were reported in animal models of Alzheimer's disease and accelerated ageing [10,26,46], multiple sclerosis [47,48], Huntington's disease [9,49], Parkinson's disease [22,50], and even reducing peripheral axonal degeneration [51] or promoting functional recovery after traumatic spinal cord injury [23]. In this sense, resveratrol has been also reported to exert neuroprotection on in vitro models of ALS.…”

Grape Secondary Metabolites – Benefits for Human Health

“…As contributing factors to the disease, mitochondrial dysfunction, inflammation, oxidative stress and apoptosis appear to have a major role in the development and progression of PD. Recent studies showed that resveratrol has neuroprotective function against the deleterious effect of 6-hydroxydopamine (6-OHDA) in rat models of PD (Jin et al, 2008;Khan et al, 2010). The conducted trials revealed that resveratrol suppresses the expression of pro-inflammatory cytokines (TNF-α) and enzymes (COX-2), which play a key role in the inflammatory process that is related with the progression of neurodegenerative diseases.…”

“…The conducted trials revealed that resveratrol suppresses the expression of pro-inflammatory cytokines (TNF-α) and enzymes (COX-2), which play a key role in the inflammatory process that is related with the progression of neurodegenerative diseases. Jin et al (2008) demonstrated that the overexpression of COX-2 and TNF-α mRNA is involved in the pathogenesis of PD and resveratrol can be used to reduce the levels of these proteins, resulting in improvement of pathological lesions in substantia nigra neurons in rat models of PD. These results confirm the beneficial effect of resveratrol in the treatment of PD.…”