Neuroprotective effect of Shenqi Fuzheng injection pretreatment in aged rats with cerebral ischemia/reperfusion injury

Cai, Yingmin; Zhang, Yong; Zhang, Peng-bo; Zhen, Luming; Sun, Xuehua; Zhi-ling, Wang; Ren, Xu; Xue, Renyu

doi:10.4103/1673-5374.175052

Cited by 18 publications

(34 citation statements)

References 39 publications

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“…Additionally, the gene expression pattern in blood indicates that biological pathways associated with oxidative stress, inflammation, apoptosis, and immune activation are involved in AD [ 110 , 111 ]. The dysfunction of smooth muscle, which is responsible for regulating blood vessels, could lead to AD complications, such as atherosclerosis and other vascular diseases [ 22 ]. In total, these data indicated that the combination of ATR and CR effectively prevents AD not only in the brain but also in other organs.…”

Section: Resultsmentioning

confidence: 99%

“…Nannf., Dang Shen in Chinese) functions by reinforcing qi (vital energy), improving the immune system, and reducing blood pressure and also has an antidiabetic effect by reducing the blood glucose level and inhibiting reactive oxygen species (ROS)-induced damage [ 20 , 21 ]. Injection of CR has neuroprotective effects based on blockade of brain Ca 2+ accumulation and improvement in superoxide dismutase activity [ 22 ]. For enhanced efficiency, CR is usually combined with ATR, such as Tiaoxin Recipe [ 23 ] and Shen-Zhi-Ling oral liquid [ 24 ], and it is known as a monarch, minister, assistant, and guide in TCM.…”

Section: Introductionmentioning

confidence: 99%

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Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer’s Disease Based on Systems Pharmacology

Liu

Liao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background and Aim. Alzheimer’s disease (AD) is a common neurological disorder worldwide. In traditional Chinese medicine (TCM), Acori Tatarinowii Rhizoma (ATR) and Codonopsis Radix (CR) are common herbs used to treat AD. However, due to the many active ingredients and targets in these herbs, it is difficult to clarify the synergistic mechanism of ATR and CR. To reveal the multicomponent synergistic mechanism of ATR and CR in Alzheimer’s disease, we analyzed important components, drug targets, and crucial pathways using a systems pharmacology strategy. Materials and Methods. In this study, a systems pharmacology-based strategy was used to elucidate the synergistic mechanism of Acori Tatarinowii Rhizoma and Codonopsis Radix for the treatment of AD. This novel systems pharmacology model consisted of component information, pharmacokinetic analysis, and pharmacological data. Additionally, the related pathways were compressed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, and the organ distributions were determined in the BioGPS bank. Results. Sixty-eight active ingredients with suitable pharmacokinetic profiles and biological activities were selected through ADME screening in silico. Based on 62 AD-related targets, such as APP, CHRM1, and PTGS1, systematic analysis showed that these two herbs were mainly involved in the PI3K-Akt signaling pathway, MAPK signaling pathway, neuroactive ligand-receptor interaction, and fluid shear stress and atherosclerosis, indicating that they had a synergistic effect on AD. However, ATR acted on the KDR gene, while CR acted on IGF1R, MET, IL1B, and CHUK, showing that they also had complementary effects on AD. The ingredient contribution score involved 29 ingredients contributing 90.14% of the total contribution score of this formula for AD treatment, which emphasized that the effective therapeutic effects of these herbs for AD were derived from both ATR and CR, not a single herb. Organ distribution showed that the targets of the active ingredients were mainly located in the whole blood, the brain, and the muscle, which are associated with AD. Conclusions. In sum, our findings suggest that the systems pharmacology methods successfully revealed the synergistic and complementary mechanisms of ATR and CR for the treatment of AD.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer’s Disease Based on Systems Pharmacology

Liu

Liao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…When excess free radicals are generated and accumulated in the body, they can cause neuronal damage. A study reported that compared with the cerebral I/R injury rats, rats treated with Shenqi Fuzheng injection displayed lower MDA content and higher SOD activity, which indicated that Shenqi Fuzheng injection may have the ability to scavenge oxidative radicals [ 14 ]. In the present study, rats in the I/R group had lower SOD activity and higher MDA content than those in the sham-operated group.…”

Section: Discussionmentioning

confidence: 99%

“…Traditional medicines are typically composed of natural products which are promising sources of new ingredients for development of conventional medicines. Recent studies have demonstrated that Scutellaria baicalensis stem-leaf [ 13 ], Radix Astragali , Radix Codonopsis [ 14 ], and other herbal prescriptions [ 15 ] exert a positive protective effect on neurological disorders caused by cerebral infarction, indicating that Chinese herbs have become a focus of research for treatment of I/R injury. Yiqi Xingnao (YQXN) oral liquid is improved from Buyang Huanwu decoction, which is a classic prescription for the treatment of stroke.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Yiqi Xingnao Oral Liquid on Cerebral Ischemia‐Reperfusion Injury in Rats and Its Related Mechanisms

Pang

Zhao

zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Purpose. This study aimed to investigate the effects of different concentrations of Yiqi Xingnao (YQXN) oral liquid on cerebral ischemia/reperfusion (I/R) injury in rats and YQXN’s related mechanisms. Methods. Rats were pretreated with 3 mL/kg, 6 mL/kg, and 12 mL/kg YQXN and Naoxuekang capsule (NXK). Afterwards, cerebral I/R model rats were established by a middle cerebral artery occlusion surgery. Neurological deficits, histopathology, and cerebral infarction volume were used to evaluate the effects of YQXN. Evans blue and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining were utilized to determine the blood-brain barrier permeability and cell apoptosis, respectively. The expression of VEGF and Bcl-2 was analyzed by real-time quantification PCR (RT-qPCR) and western blot. The malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were measured using corresponding assay kits. Results. The rats pretreated with YQXN had improved neurological deficits, reduced infarct volume and blood-brain barrier permeability, and ameliorated ischemia-induced morphology change in injured brain tissues. TUNEL staining results showed that different concentrations of YQXN inhibited cell apoptosis of neurocytes in I/R rats. Besides, RT-qPCR and western blot analyses indicated that the expression levels of VEGF and Bcl-2 were significantly upregulated by YQXN compared with the I/R group (P<0.05). Additionally, rats in the I/R group had lower SOD activity and higher MDA content than those in the sham-operated group, while their levels were recovered by YQXN (P<0.05). Conclusion. YQXN could alleviate cerebral I/R injury by suppressing blood-brain barrier permeability, neuron apoptosis, and oxidative stress, promoting angiogenesis.

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“…Most ethnic drugs for treatment of ischemic stroke have the function of activating blood circulation to remove blood stasis or clear collaterals. NaoShuanTong capsule (Zhang H. et al, 2019), ShenQi Fuzheng injection (Cai et al, 2016), ShengMai injection (Yang et al, 2016), and PeiYuan TongNao capsule have been reported to significantly improve the symptoms of ischemic stroke with few adverse events. In recent years, some antiapoptotic protective effects of cerebral ischemia have also been reported, such as XueShuanTong injection (Li et al, 2009) and QianCao NaoMaiTong mixture (Lu et al, 2016).…”

Section: Authorized Products For Stroke Improvement By Regulating Mitmentioning

confidence: 99%

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

Sun

et al. 2020

Front. Pharmacol.

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Mammalian mitochondrial permeability transition pore (MPTP), across the inner and outer membranes of mitochondria, is a nonspecific channel for signal transduction or material transfer between mitochondrial matrix and cytoplasm such as maintenance of Ca 2+ homeostasis, regulation of oxidative stress signals, and protein translocation evoked by some of stimuli. Continuous MPTP opening has been proved to stimulate neuronal apoptosis in ischemic stroke. Meanwhile, inhibition of MPTP overopening-induced apoptosis has shown excellent efficacy in the treatment of ischemic stroke. Among of which, the potential molecular mechanisms of drug therapy for stroke has also been gradually revealed by researchers. The characteristics of multi-components or multitargets for ethnic drugs also provide the possibility to treat stroke from the perspective of mitochondrial MPTP. The advantages mentioned above make it necessary for us to explore and clarify the new perspective of ethnic medicine in treating stroke and to determine the specific molecular mechanisms through advanced technologies as much as possible. In this review, we attempt to uncover the relationship between abnormal MPTP opening and neuronal apoptosis in ischemic stroke. We further summarized currently authorized drugs, ethnic medicine prescriptions, herbs, and identified monomer compounds for inhibition of MPTP overopening-induced ischemic neuron apoptosis. Finally, we strive to provide a new perspective and enlightenment for ethnic medicine in the prevention and treatment of stroke by inhibition of MPTP overopeninginduced neuronal apoptosis.

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Neuroprotective effect of Shenqi Fuzheng injection pretreatment in aged rats with cerebral ischemia/reperfusion injury

Cited by 18 publications

References 39 publications

Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer’s Disease Based on Systems Pharmacology

Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer’s Disease Based on Systems Pharmacology

Protective Effects of Yiqi Xingnao Oral Liquid on Cerebral Ischemia‐Reperfusion Injury in Rats and Its Related Mechanisms

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

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