Neuroprotective effect of short‐chain fatty acids against oxidative stress‐induced SH‐SY5Y injury via GPR43‐dependent pathway

Abstract

A neurodegenerative disorder is a condition that causes a degeneration of neurons in the central nervous system, leading to cognitive impairment and movement disorders. An accumulation of oxidative stress in neurons contributes to the pathogenesis of neurodegenerative disorders. Over the past few years, several studies have suggested that short-chain fatty acids, metabolites of the gut microbiota, might have a beneficial effect in neurodegenerative disorders. A G protein-coupled receptor 43

Evaluation of in vitro prebiotic effects of galactomannan oligosaccharides derived from guar gum

“…SCFAs are the essential metabolic products of oligosaccharides fermented by intestinal microorganisms. It has been reported that SCFAs have a variety of physiological functions and a wide range of applications in the treatment of diseases (Li et al ., 2023; Saikachain et al ., 2023). The composition and concentration of SCFAs in the control group, FOS group, and GMOS group during in vitro fermentation are shown in Fig.…”

Gut Microbiota Metabolite Messengers in Brain Function and Pathology at a View of Cell Type-Based Receptor and Enzyme Reaction

“…Studies focused on GPR41/GPR43 functions suggest their role in modulating oxidative stress and inflammation in various tissues, including neuronal cells. Some studies investigated the protective role of SCFAs and GPR41 activation against oxidative stress-induced neuronal cell injury ( Saikachain et al ., 2023 ) ( Fig. 1D ).…”