Neuroprotective effect of sinapic acid in a mouse model of amyloid β1–42 protein-induced Alzheimer's disease

Lee, Hyung Eun; Kim, Dong Hyun; Park, Se Jin; Kim, Jong Min; Lee, Young Woo; Jung, Jun Man; Lee, Chang Hwan; Hong, Jin Gyu; Liu, Xiaotong; Cai, Mudan; Park, Keon Ju; Jang, Dae Sik; Ryu, Jong Hoon

doi:10.1016/j.pbb.2012.08.015

Cited by 94 publications

(62 citation statements)

References 54 publications

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“…Sinapic acid is a phenylpropanoid compound that is found in various herbal materials including cereals, nuts, oil seeds, and berries (Shin et al 2013). Sinapic acid has shown antioxidant activity (Roy and Mainzen Prince 2013), metal chelating potential (Pari and Mohamed Jalaludeen 2011), antiinflammatory (Yun et al 2008) and neuroprotective properties (Lee et al 2012). This compound also exhibits protective potential against lysosomal dysfunction (Roy and Stanely Mainzen Prince 2012) and protects rat liver from carbon tetrachloride-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB activation and proinflammatory cytokine expression (Shin et al 2013).…”

Section: Introductionmentioning

confidence: 99%

The neuroprotective potential of sinapic acid in the 6-hydroxydopamine-induced hemi-parkinsonian rat

et al. 2014

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Parkinson's disease (PD) is a neurodegenerative movement disorder due to selective loss of dopaminergic neurons of mesencephalic substantia nigra pars compacta (SNC) with debilitating motor symptoms. Current treatments for PD afford symptomatic relief with no prevention of disease progression. Due to the antioxidant and neuroprotective potential of sinapic acid, this study was conducted to evaluate whether this agent could be of benefit in an experimental model of early PD in rat. Unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated p.o. with sinapic acid at doses of 10 or 20 mg/kg. One week after surgery, apomorphine caused significant contralateral rotations, a significant reduction in the number of Nissl-stained and tyrosine hydroxylase (TH)-positive neurons and a significant increase of iron reactivity on the left side of SNC. Meanwhile, malondialdehyde (MDA) and nitrite levels in midbrain homogenate significantly increased and activity of superoxide dismutase (SOD) significantly reduced in the 6-OHDA-lesioned group. In addition, sinapic acid at a dose of 20 mg/kg significantly improved turning behavior, prevented loss of SNC dopaminergic neurons, lowered iron reactivity, and attenuated level of MDA and nitrite. These results indicate the neuroprotective potential of sinapic acid against 6-OHDA neurotoxicity that is partially due to the attenuation of oxidative stress and possibly lowering nigral iron level.

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Section: Introductionmentioning

confidence: 99%

The neuroprotective potential of sinapic acid in the 6-hydroxydopamine-induced hemi-parkinsonian rat

et al. 2014

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“…Aggregated Aβ 1-42 peptide (3 μl) was then unilaterally injected into the hippocampal region (anterior-posterior, -2.00 mm; mediallateral, 1.50 mm; dorsal-ventral, 1.0 mm) [19]. Mice in the control group were injected with saline.…”

Section: Aβ 1-42 Protein Injection and Drug Administrationmentioning

confidence: 99%

Brain Metabolomics Study on the Protective Effects of Ginsenosides Rg1 and Rb1 in an Alzheimer’s Disease Mouse Model

Li¹

2015

Pharm Anal Chem

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“…Sinapic acid (SA): shows cerebral protective and cognitionimproving medicine.SA has anti-oxidative and anti-inflammatory activities, and may be an efficacious treatment for Alzheimer's disease [13]. Daucosterol: The treatment with DS-given mice with anti-mouse IFNγ, the protection was also abolished.…”

Section: Snomentioning

confidence: 99%

Phytochemical Analysis of Cynanchum callialatum through GCMS and LCMS

Muthusamy¹

2014

J Homeop Ayurv Med

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Medicinal plants are still important source for drug discovery. Herbal medicines have gained importance in recent years because of their efficacy and cost effectiveness. The objective of the present study is to investigate the phytochemical present in the Cynanchum callialatum. The phytochemical analysis was done by preliminary phytochemical test for secondary metabolites, GCMS for volatile constituents and LCMS for nonvolatile constituents.The phytochemical test confirms the presents of alkaloids, flavonoids, terpenoids, tanins etc. The GCMS analysis shows the presents of 52 compounds in which some have medicinal value. The LCMS analysis shows the presents of compounds in which most of them have the medicinal properties. The present study on Cynanchum callialatum reveals the presence of various phytochemical constituents like Betulinic acid, Lupeol, Germacrone and Longiverbenone. Cynanchum callialatum may be a potential source for anticancer, antiHIV, antiinflammatory, antimicrobial drug discovery.

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Neuroprotective effect of sinapic acid in a mouse model of amyloid β1–42 protein-induced Alzheimer's disease

Cited by 94 publications

References 54 publications

The neuroprotective potential of sinapic acid in the 6-hydroxydopamine-induced hemi-parkinsonian rat

The neuroprotective potential of sinapic acid in the 6-hydroxydopamine-induced hemi-parkinsonian rat

Brain Metabolomics Study on the Protective Effects of Ginsenosides Rg1 and Rb1 in an Alzheimer’s Disease Mouse Model

Phytochemical Analysis of Cynanchum callialatum through GCMS and LCMS

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