2003
DOI: 10.1200/jco.2003.05.139
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Neuroprotective Effect of Vitamin E Supplementation in Patients Treated With Cisplatin Chemotherapy

Abstract: Supplementation of patients receiving cisplatin chemotherapy with vitamin E decreases the incidence and severity of peripheral neurotoxicity.

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Cited by 278 publications
(227 citation statements)
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“…In particular, glutathione, N-acetylcysteine, and vitamin E (a-tocopherol) may have a clinical role in patient neuroprotection. 4,6,7,25,29,35 However, the major bias of these clinical trials resides in their small size and/ or in their short term follow-up. 2 An important limit in this field is the insufficient information on the molecular basis of the neuropathy.…”
mentioning
confidence: 99%
“…In particular, glutathione, N-acetylcysteine, and vitamin E (a-tocopherol) may have a clinical role in patient neuroprotection. 4,6,7,25,29,35 However, the major bias of these clinical trials resides in their small size and/ or in their short term follow-up. 2 An important limit in this field is the insufficient information on the molecular basis of the neuropathy.…”
mentioning
confidence: 99%
“…A small, randomized trial enrolled 47 subjects to either usual care or to 300 mg of alpha-tocopherol twice a day throughout treatment with cisplatin chemotherapy, and for 3 months after completion [151]. Of the 27 subjects who completed the trial, the vitamin E group (n ¼ 13) showed a decreased incidence (31% versus 86%; P < .01) as well as decrease in severity (P < .01) of neurotoxicity.…”
Section: Neuropathymentioning
confidence: 99%
“…Decreased rate of neuropathy [151][152][153][154] Ginger postoperatively in surgical cancer patients; with MOPP chemotherapy; with cisplatin chemotherapy Decreased nausea [155][156][157] Calendula homeopathic lotion in radiation therapy…”
Section: Grifola Umbellatae In Bladder Cancermentioning
confidence: 99%
“…Although normal pain relief does not reduce the pain associated with CIPN, no specific anti-inflammatory drug has been trialled as a protective agent. This is one of the main mechanisms of action that has been identified in the nutrients and the herbs trialled for CIPN that have shown a possible beneficial protective effect [233][234][235][236][237][238][239][240][241][242][243][244][245][246]. The anti-inflammatory component may or may not protect patients against CIPN but it would be an interesting aspect to investigate.…”
Section: Strengths and Weaknesses And Gaps In The Researchmentioning
confidence: 99%
“…Vitamin E was demonstrated to have positive results in three RCT's showing a significant reduction in the relative risk of cisplatin induced PN, especially ototoxicity [233][234][235][236]254]. However, a phase III multi-centre trial combining vitamin E with taxanes, cisplatin, carboplatin, oxaliplatin or combination concluded that vitamin E did not appear to reduce the incidence of sensory neuropathy [254].…”
Section: Vitamin Ementioning
confidence: 99%