Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms

Jiang, Yumao; Li, Zongyang; Liu, Yamin; Liu, Xinmin; Chang, Qi; Liao, Yonghong; Pan, Rui‐Le

doi:10.1016/j.jep.2014.10.062

Cited by 42 publications

(22 citation statements)

References 53 publications

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“…Glucocorticoids are also a potent antiinflammatory drug and could be used in PD therapeutics. Studies have shown the protective effect of glucocorticoid in experimental models of PD (Jiang et al, 2015;Tentillier et al, 2016). Dexamethasone, a synthetic glucocorticoid receptor ligand, and genistein, an isoflavone, protect the neuronal SK-N-SH cells against 6-OHDA-induced apoptosis by upregulating the Bax and downregulating the Bcl proteins (Gao, Xie, Wong, & Chen, 2012).…”

Section: R E La Te D T He Ra P E U Ti C I N Te Rv E Nti Onmentioning

confidence: 99%

Updates on immunity and inflammation in Parkinson disease pathology

Joshi

Singh

2017

J of Neuroscience Research

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Studies in the last decade have suggested the association of both neuroinflammatory processes and immune responses in Parkinson disease (PD) pathology. PD pathology is related to depleted dopamine levels, α-synuclein aggregation, and death of nigrostriatal dopaminergic neurons. Reports have suggested central and peripheral inflammation in the prodromal stage of the disease, which is sustained during disease progression. Alongside the activation of peripheral immune system exacerbates the dissonant central inflammatory responses and could contribute in synergistic neurodegeneration. Activated glial cells contribute significantly in the neuroinflammatory process during the occurrence of the disease and are also acknowledged as a hallmark of disease progression. However, the contribution of glial cells is not well defined in the context of neurodegeneration and neuroprotection. This review provides an overview of the roles of immune and inflammatory responses and their consequences in PD disease pathogenesis and also discusses possible therapeutic strategies for PD based on these findings.

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Section: R E La Te D T He Ra P E U Ti C I N Te Rv E Nti Onmentioning

confidence: 99%

Updates on immunity and inflammation in Parkinson disease pathology

Joshi

Singh

2017

J of Neuroscience Research

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“…Furthermore, ginseng consumption led to a reduction in the expression levels of genes associated with lipid metabolism, as well as in the levels of leptin, insulin and adiponectin, all of which perform critical functions in the control of obesity . Recently, wild ginseng was shown to restore mitochondrial dysfunction against oxidative stress and neurodegenerative diseases in in‐vivo and in‐vitro studies . Ginseng, however, is rare and its rarity makes it very expensive.…”

Section: Introductionmentioning

confidence: 99%

“…[10] Recently, wild ginseng was shown to restore mitochondrial dysfunction against oxidative stress and neurodegenerative diseases in in-vivo and invitro studies. [11,12] Ginseng, however, is rare and its rarity makes it very expensive. Furthermore, the yield of active components from ginseng can be highly variable depending on the field cultivation.…”

Section: Introductionmentioning

confidence: 99%

Wild ginseng cambial meristematic cells ameliorate hepatic steatosis and mitochondrial dysfunction in high-fat diet-fed mice

Lee

Cho

Jin³

et al. 2016

Journal of Pharmacy and Pharmacology

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“…Acute corticosterone administration can result in anxiety and amygdaloid dendritic hypertrophy [9]. Moreover, chronic corticosterone exposure induces neuronal damage in hippocampus [10] and depressive-like behavior in animal model [11], apoptosis and injury of PC12 cells in vitro [12,13]. Interestingly, corticosterone can cause synaptic degeneration and exert toxic effects on hippocampal neurons, and finally induces depression [14].…”

Section: Introductionmentioning

confidence: 99%

H<sub>2</sub>S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway

Gao

Zou

et al. 2015

ABBS

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Corticosterone, one of the glucocorticoids, is toxic to neurons and plays an important role in depressive-like behavior and depression. We previously showed that hydrogen sulfide (H 2 S), a novel physiological mediator, plays an inhibitory role in depression. However, the mechanism underlying H 2 S-triggered antidepressant-like role is not clearly known. Brain-derived neurotrophic factor (BDNF), a neurotrophic factor, plays a neuroprotective role that is mediated by its high-affinity tropomysin-related kinase B (TrkB) receptor. In this study, to investigate the underlying mechanism of H 2 S-induced antidepressant-like role, we explored whether H 2 S could protect neurons against corticosterone-mediated cyctotoxicity and whether this protective role of H 2 S was involved in the regulation of BDNF-TrkB pathway. Our data demonstrated that sodium hydrosulfide (NaHS), the donor of H 2 S, could prevent corticosterone-induced cytotoxicity, apoptosis, accumulation of intracellular reactive oxygen species (ROS) and loss of mitochondrial membrane potential (MMP) in PC12 cells. NaHS not only induced the up-regulation of BDNF but also prevented the down-regulation of BDNF by corticosterone. It was also found that blocking BDNF-TrkB pathway by K252a, an inhibitor of TrkB, abolished the protection of H 2 S against corticosterone-induced cytotoxicity, apoptosis, accumulation of ROS, and loss of MMP. These results suggest that H 2 S protects against the neurotoxicity of corticosterone by modulation of the BDNF-TrkB pathway.

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Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms

Cited by 42 publications

References 53 publications

Updates on immunity and inflammation in Parkinson disease pathology

Updates on immunity and inflammation in Parkinson disease pathology

Wild ginseng cambial meristematic cells ameliorate hepatic steatosis and mitochondrial dysfunction in high-fat diet-fed mice

H<sub>2</sub>S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway

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Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms

Cited by 42 publications

References 53 publications

Updates on immunity and inflammation in Parkinson disease pathology

Updates on immunity and inflammation in Parkinson disease pathology

Wild ginseng cambial meristematic cells ameliorate hepatic steatosis and mitochondrial dysfunction in high-fat diet-fed mice

H&lt;sub&gt;2&lt;/sub&gt;S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway

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H<sub>2</sub>S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway