Neuroprotective Effects of 5-HT1A Receptor Agonists

Peruche, Barbara; Ausmeier, Franz; Backhauß, Cord; Nuglisch, Jörg; Prehn, Jochen H.M.; Krieglstein, Josef

doi:10.1007/978-3-642-78151-3_22

Cited by 1 publication

(1 citation statement)

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“…There is probably also a direct hypoxic activation of raphe neurones, because 5-HT levels remained elevated during and shortly after hypoxic apnoea. Persistent activation of 5-HT-1A receptors may protect the respiratory network by curtailing influx of calcium ions into neurones and serve to protect against hypoxic impairment of brain structure and function (Shibata et al 1992;Peruch et al 1994). …”

Section: Technical Considerationsmentioning

confidence: 99%

Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized cats

Richter

Schmidt-Garcon

Pierrefiche

et al. 1999

The Journal of Physiology

189

162

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1. The contributions of neurotransmitters and neuromodulators to the responses of the respiratory network to acute hypoxia were analysed in anaesthetized cats. 2. Samples of extracellular fluid were collected at 1-1·5 min time intervals by microdialysis in the medullary region of ventral respiratory group neurones and analysed for their content of glutamate, ã_aminobutyric acid (GABA), serotonin and adenosine by high performance liquid chromatography. Phrenic nerve activity was correlated with these measurements. 3. Levels of glutamate and GABA increased transiently during early periods of hypoxia, coinciding with augmented phrenic nerve activity and then fell below control during central apnoea. Serotonin and adenosine increased slowly and steadily with onset of hypoxic depression of phrenic nerve activity. 4. The possibility that serotonin contributes to hypoxic respiratory depression was tested by microinjecting the 5-HT-1A receptor agonist 8-OH-DPAT into the medullary region that is important for rhythmogenesis. Hypoxic activation of respiratory neurones and phrenic nerve activity were suppressed. Microinjections of NAN-190, a 5-HT-1A receptor blocker, enhanced hypoxic augmentation resulting in apneustic prolongation of inspiratory bursts. 5. The results reveal a temporal sequence in the release of neurotransmitters and neuromodulators and suggest a specific role for each of them in the sequential development of hypoxic respiratory disturbances.8538

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Section: Technical Considerationsmentioning

confidence: 99%