Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review

Zhang, Jinlin; Wu, Jingjing; Liu, Fengguo; Tong, Lijuan; Chen, Zhuo; Chen, Jinliang; He, Haiyan; Xu, Rong; Ma, Yao‐Ying; Huang, Chao

doi:10.1016/j.ejphar.2019.172500

Cited by 98 publications

(71 citation statements)

References 131 publications

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“…Globally, anthocyanins and anthocyanins-rich foods are able to improve metabolic homeostasis. More recently, anthocyanins have also revealed promising effects on cognitive function [ 51 , 77 , 78 , 79 ].…”

Section: Anthocyaninsmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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Section: Anthocyaninsmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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“…Patients suffering from Parkinson’s or Alzheimer’s diseases show lower levels of BDNF [ 25 ], and this is associated to an increase in degeneration of dopaminergic neurons in the former [ 26 ] and to memory impairment in the latter [ 27 ]. In this context, the modulation of BDNF has emerged as another promising therapeutic approach to counteract neurodegeneration, and anthocyanins have been suggested as potential modulating agents [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Fruit Quality Characterization of New Sweet Cherry Cultivars as a Good Source of Bioactive Phenolic Compounds with Antioxidant and Neuroprotective Potential

et al. 2020

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Sweet cherries (Prunus avium L.) are highly appreciated fruits for their taste, color, nutritional value, and beneficial health effects. In this work, seven new cultivars of sweet cherry were investigated for their main quality traits and nutraceutical value. The phytochemical profile of three classes of phenolic compounds and the antioxidant activity of the new cultivars were investigated through high-performance liquid chromatography with diode array detection (HPLC-DAD) and spectrophotometric assays, respectively, and compared with those of commonly commercialized cultivars. Cyanidine-3-O-rutinoside was the main anthocyanin in all genotypes, and its levels in some new cultivars were about three-fold higher than in commercial ones. The ORAC-assayed antioxidant capacity was positively correlated with the total anthocyanin index. The nutraceutical value of the new cultivars was investigated in terms of antioxidant/neuroprotective capacity in neuron-like SH-SY5Y cells. Results demonstrated that the new cultivars were more effective in counteracting oxidative stress and were also able to upregulate brain-derived neurotrophic factor (BDNF), a pro-survival neurotrophin, suggesting their potential pleiotropic role in counteracting neurodegenerations.

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“…These studies have shown the neuroprotective effect of ACNs in rat or mouse models of cerebral ischemia and defined some of the possible mechanisms of protection (Zhang et al, 2019).…”

Section: Cerebral Ischemiamentioning

confidence: 99%

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

et al. 2020

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Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.

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Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review

Cited by 98 publications

References 131 publications

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Fruit Quality Characterization of New Sweet Cherry Cultivars as a Good Source of Bioactive Phenolic Compounds with Antioxidant and Neuroprotective Potential

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

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