Neuroprotective effects of aripiprazole in stress-induced depressive-like behavior: Possible role of CACNA1C

Dashti, Somayeh; Nahavandi, Arezo

doi:10.1016/j.jchemneu.2022.102170

Cited by 4 publications

(2 citation statements)

References 78 publications

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“…The neuroprotective effects of aripiprazole in depression-like behavior caused by stress were studied by Dashti et al (2022). It was found that aripiprazole can promote synaptic plasticity by improving the expression of BDNF and GAP-43 genes.…”

Section: The Use Of Aripiprazole For the Correction Of Behavioral Dis...mentioning

confidence: 99%

The use of anxiolytic drugs for the correction of behavioral disorders in mammals

Poroshinska,

Polishchuk,

Shmayun

et al. 2024

Regul. Mech. Biosyst.

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The issue of stress and behavioral disorders are growing significantly in the contemporary word in humans and animals alike. Various drugs are used to modify affected behavior, including psychotropic, anticonvulsant, antihistamines, hormones, analgesics, and neuroleptics. Psychotropic drugs are prescribed for animals with behavioral disorders, signs of anxiety or hypersensitivity. Improving the methods of diagnosing and treating behavioral disorders in animals can enhance animal welfare and optimize animal husbandry technology. Future research should be aimed at improving and optimizing the use of psychotropic drugs for behavioral disorders of various animal species. The main indication for the use of anxiolytic drugs is behavioral disorders associated with anxiety in wild and domestic animals. When anxiolytic drugs are used in mammals their pharmacological properties, the dependence of their action on the route of administration, age and species of the animal, and the ability to selectively affect the central nervous system should be taken into account. The most commonly used drugs for the treatment of behavioral disorders in animals are fluoxetine, amitriptyline, escitalopram, haloperidol, zuclopentixol and azaperone. Fluoxetine is an effective drug for the treatment of dogs with behavioral disorders associated with psychological changes. An important component of escitalopram's pharmacological effect is the psychomotor influence, when the animal's behavior changes are due to improved motor activity. Zuclopentixol has a wide range of anxiolytic, sedative and analgesic effects when used in wild cloven-hoofed animals. Amitriptyline along with antidepressant properties, has a local analgesic impact. Azaperone has a pronounced anxiolytic and sedative effect on animals. It is widely used as an anti-stress agent to overcome anxiety caused by weaning, regrouping or veterinary manipulations. Azaperone is often used to control aggressive behavior in group housing, especially in the pig industry. The psychotropic drugs surveyed in this paper, along with direct anxiolytic action, are able to manifest additional physiological effects, which should be taken into account when developing treatment protocols for animals with behavioral problems. Further targeted studies are required to assess the pharmacological effects of anxiolytic drugs in animals.

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Section: The Use Of Aripiprazole For the Correction Of Behavioral Dis...mentioning

confidence: 99%

The use of anxiolytic drugs for the correction of behavioral disorders in mammals

Poroshinska,

Polishchuk,

Shmayun

et al. 2024

Regul. Mech. Biosyst.

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“…Moreover, the stimulation of APZ has been noted to down-regulate the mRNA levels of IL-1β, TNF-α, and IL-6 in human immune cells [18]. Furthermore, in a rat model exposed to stress, treatment with APZ has been linked to a decrease in peripheral IL-6 levels and a reduction in hippocampal cell death [19]. Moreover, it has been proposed that oxidative stress and apoptosis may be involved in the onset of certain neurological conditions, such as dementia and schizophrenia [20].…”

Section: Introductionmentioning

confidence: 99%

Aripiprazole Attenuates Cognitive Impairments Induced by Lipopolysaccharide in Rats through the Regulation of Neuronal Inflammation, Oxidative Stress, and Apoptosis

Mani,

Alshammeri

2023

Medicina

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Background and Objectives: Aripiprazole (APZ), an atypical antipsychotic, is mainly prescribed for conditions such as schizophrenia and bipolar disorder, while ongoing research indicates promising neuroprotective qualities. APZ’s mechanism of action, involving the regulation of neurotransmitter levels, appears to contribute to its potential to shield neural tissues from specific forms of harm and degeneration. Materials and Methods: To investigate its neuroprotective mechanisms, groups of rats were orally administered APZ at 1 or 2 mg/kg once daily for a 30-day period. In addition, neuronal toxicity was induced through intraperitoneal injection of four doses of lipopolysaccharide (LPS) at a concentration of 1 mg/kg. To evaluate cognitive function, particularly, short-term recognition memory, the procedure implemented the novel object recognition (NOR) task. Subsequently, brain tissues were gathered to examine markers linked with neuroinflammation, oxidative stress, and apoptosis. Results: The administration of LPS led to a decline in memory performance during the NOR tasks. Simultaneously, this LPS treatment raised inflammatory markers like cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-α, and nuclear factor kappa B (NF-κB), increased oxidative markers such as malondialdehyde (MDA), and triggered apoptosis markers like Caspase-3 and Bcl2 associated X protein (Bax) within the brain. Furthermore, it decreased levels of antioxidants like reduced glutathione (GSH) and catalase, as well as the anti-apoptotic marker B-cell lymphoma (Bcl)-2 in brain tissue. The use of APZ resulted in enhanced recognition memory performance, as indicated by improved exploration and discrimination abilities of the objects in the NOR task. Moreover, APZ lowered the markers associated with neuronal vulnerability, such as COX-2, NF-κB, MDA, Caspase-3, and Bax. Additionally, it increased the levels of protective markers, including GSH, catalase, and Bcl-2 in LPS-challenged brains. Conclusions: In summary, the findings suggest that APZ exhibits protective properties against neuronal inflammation, oxidative stress, and apoptosis markers in the context of inflammatory-related neurodegeneration. Additional in-depth investigations are needed to further explore potential applications.

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Pharmacological mechanism of natural antidepressants: The role of mitochondrial quality control

Lv,

Zhang,

et al. 2024

Phytomedicine

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Neuroprotective effects of aripiprazole in stress-induced depressive-like behavior: Possible role of CACNA1C

Cited by 4 publications

References 78 publications

The use of anxiolytic drugs for the correction of behavioral disorders in mammals

The use of anxiolytic drugs for the correction of behavioral disorders in mammals

Aripiprazole Attenuates Cognitive Impairments Induced by Lipopolysaccharide in Rats through the Regulation of Neuronal Inflammation, Oxidative Stress, and Apoptosis

Pharmacological mechanism of natural antidepressants: The role of mitochondrial quality control

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