Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin

Oliveira, Juliana Sorraila de; Abdalla, Fátima Husein; Dornelles, Guilherme Lopes; Palma, Taís Vidal; Signor, Cristiane; Bernardi, Jamile da Silva; Baldissarelli, Jucimara; Lenz, Luana Suéling; Oliveira, Vinicius de Abreu; Schetinger, Maria Rosa Chitolina; Morsch, Vera Maria; Rubin, Maribel Antonello; Andrade, Cínthia Melazzo de

doi:10.1007/s00213-018-5090-6

Cited by 26 publications

(14 citation statements)

References 95 publications

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“…In addition, berberine reduced hyperphosphorylation of tau and APP [29,39], possibly through inactivation of GSK3β via Akt signaling [29]. On the other hand, growing evidence suggests that berberine prevents dementia associated with diabetes [43][44][45][46][47][48][49][50][51][52][53][54][55][61][62][63] (Table 2). Berberine inhibited apoptosis in the hippocampus and cerebral cortex, suppressed anxiety and restored recognition memory in the sporadic AD model induced by intracerebroventricular injection of streptozotocin (STZ), possibly via reduction of AChE activity [44,51].…”

Section: Ischemia-reperfusion Injury In T2dmmentioning

confidence: 99%

“…Berberine was able to promote cognitive functions [38,40], through enhancing cholinergic neurotransmission [30,33,36,41]. In addition, berberine alleviated diabetes-associated cognitive impairment [44,45,48,49,[51][52][53][54][55], possibly via the restoration of insulin signaling [50,51] and reduction of oxidative stress and inflammation [43,46,47] in the brain. Although bioavailability of berberine is relatively low, it crosses the blood brain barrier and stably distributes in the brain tissue, compared to other organs [162], suggesting that berberine could prevent dementia through direct actions in the brain.…”

Section: Direct Evidence Supporting Berberine's Antidementia Effectsmentioning

confidence: 99%

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Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Shinjyo

Parkinson

Bell

et al. 2020

Journal of Integrative Medicine

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Section: Ischemia-reperfusion Injury In T2dmmentioning

confidence: 99%

Section: Direct Evidence Supporting Berberine's Antidementia Effectsmentioning

confidence: 99%

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Shinjyo

Parkinson

Bell

et al. 2020

Journal of Integrative Medicine

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“…In our next study, we plan to examine differences in gut microbiota in berberineand non-berberine treated mice as we hypothesize that these differences might be associated with differences in relapse propensity. Furthermore, a number of studies found that berberine has multifunctional properties and can inhibit the activity of important pathogenic enzymes, ameliorate intracellular oxidative stress, attenuate neuroinflammation, trigger autophagy, and protect neurons against recognition memory damage (de Oliveira et al, 2019;Yuan et al, 2019;Zhao et al, 2019). Undeniably, more research is needed to understand the effects of pre-extinction berberine intervention on relapse and uncover the underlying neurochemical and molecular mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Berberine Facilitates Extinction of Drug-Associated Behavior and Inhibits Reinstatement of Drug Seeking

et al. 2020

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A high rate of relapse is a major clinical problem among drug-addicted individuals. Persistent traces of drug-associated reward memories contribute to intense craving and often trigger relapse. A number of interventions on drug-associated memories have shown significant benefits in relapse prevention. Among them are pre-or post-extinction pharmacological manipulations that facilitate the extinction of drug-associated behavior. Berberine, a bioactive isoquinoline alkaloid, has been recently reported to provide therapeutic benefits for a number of central nervous system (CNS) disorders, including morphine addiction. The present study aimed to investigate whether berberine could serve as a post-extinction pharmacological intervention agent to reduce risks of reinstatement of drug seeking. We found that an intragastric administration of berberine at doses of 25 and 50 mg/kg during the critical time window significantly facilitated the extinction of morphine-reward related behavior in free access and confined conditioned place preference (CPP) extinction paradigms, and subsequently, it prevented reinstatement and spontaneous recovery of morphine-induced CPP in mice. Intriguingly, the berberine treatment with or without extinction training altered expression of plasticity-related proteins such as brain-derived neurotrophic factor (BDNF), AMPA receptors (GluA1 and GluA2) in the nucleus accumbens (NAc). Moreover, the post-extinction berberine treatment significantly reduced reinstatement of cocaine-induced CPP and operant intravenous self-administration (IVSA) memories in rats. Altogether, our findings suggest that extinction training combined with the postextinction berberine treatment can facilitate extinction of drug-associated behavior making it an attractive therapeutic candidate in relapse prevention.

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“…Oxidative stress is defined as a redox state that occurs due to an imbalance between generation and detoxification of reactive radicals in the body, which can lead to cell and tissue damage. It is one of the main causes of AD and it is one of the key hypotheses [159,160].…”

Section: Ampk and Oxidative Stressmentioning

confidence: 99%

The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence

Assefa

Tafere

Wondafrash

et al. 2020

BioMed Research International

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Alzheimer’s disease is a multifactorial neurodegenerative disease characterized by progressive cognitive dysfunction. It is the most common form of dementia. The pathologic hallmarks of the disease include extracellular amyloid plaque, intracellular neurofibrillary tangles, and oxidative stress, to mention some of them. Despite remarkable progress in the understanding of the pathogenesis of the disease, drugs for cure or disease-modifying therapy remain somewhere in the distance. From recent time, the signaling molecule AMPK is gaining enormous attention in the AD drug research. AMPK is a master regulator of cellular energy metabolism, and recent pieces of evidence show that perturbation of its function is highly ascribed in the pathology of AD. Several drugs are known to activate AMPK, but their effect in AD remains to be controversial. In this review, the current shreds of evidence on the effect of AMPK activators in Aβ accumulation, tau aggregation, and oxidative stress are addressed. Positive and negative effects are reported with regard to Aβ and tauopathy but only positive in oxidative stress. We also tried to dissect the molecular interplays where the bewildering effects arise from.

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Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin

Cited by 26 publications

References 95 publications

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Berberine Facilitates Extinction of Drug-Associated Behavior and Inhibits Reinstatement of Drug Seeking

The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence

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