Neuroprotective effects of chrysin: From chemistry to medicine

Nabavi, Seyed Fazel; Braidy, Nady; Habtemariam, Solomon; Orhan, İlkay Erdoğan; Daglia, Maria; Manayi, Azadeh; Gortzi, Olga

doi:10.1016/j.neuint.2015.09.006

Cited by 165 publications

(90 citation statements)

References 77 publications

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“…Albert Szent-Gyorgyii reported the first evidence of biological activity of flavonoids in 1938 [9]. Since then, a broad spectrum of biological activities such as anti-inflammatory, antioxidant, antibacterial, antiviral, anticancer, and neuroprotective has been described for flavonoids [10][11][12][13][14]. In this study different flavonoids and their subclasses with antioxidant, hepatoprotective, antibacterial, anti-inflammatory, anticancer and antiviral properties from different literatures [15][16] were screened against our modeled structure ofreceptor-binding domain of S protein (RBD of nCoV-SP) of 2019-CoV and human angiotensin-converting enzyme 2 (ACE-2).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Flavonoids as 2019-nCoV Cell Entry Inhibitor Through Molecular Docking and Pharmacological Analysis

Bhowmik¹,

Nandi²,

Kumar

2020

Preprint

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In this study we aimed at the receipt binding domain of S protein and ACE-2 receptor as a promising drug targets against SARS-CoV-2. Flavonoids with anti-viral properties were taken as ligand for molecular docking. Selected flavonoids showed extremely good pharmacokinetics properties with good absorption, solubility, metabolism, excretion,distribution, bioavailability and minimal toxicity. These identified lead flavonoids may act as potential compound for the development of effective drugs and may help in controlling the rapid spread of SARS-CoV-2 by potentially inhibiting the virus entry into the host cell.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Flavonoids as 2019-nCoV Cell Entry Inhibitor Through Molecular Docking and Pharmacological Analysis

Bhowmik¹,

Nandi²,

Kumar

2020

Preprint

View full text Add to dashboard Cite

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“…oyster mushroom), bee propolis and honey 12 . Chrysin is already available in market as a dietary supplement in the form of capsule (500 mg per capsule) and it is widely used as a sports supplement, with athletes taking doses up to 2–3 g per day without any associated side effects 13 .…”

Section: Introductionmentioning

confidence: 99%

Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathways

Mantawy

Esmat

El-Bakly

et al. 2017

Sci Rep

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Doxorubicin (DOX) is the mainstay chemotherapeutic agent against a variety of human neoplasmas. However, its clinical utility is limited by its marked cardiotoxicity. Chrysin, is a natural flavone which possesses antioxidant, anti-inflammatory and anti-cancer properties. The current study aimed to investigate the potential protective effect of chrysin against DOX-induced chronic cardiotoxicity and the underlying molecular mechanisms. Male Sprague-Dawley rats were treated with either DOX (5 mg/kg, once a week) and/or chrysin (50 mg/kg, four times a week) for four weeks. Chrysin prevented DOX-induced cardiomyopathy which was evident by conduction abnormalities, elevated serum CKMB and LDH and histopathological changes. Chrysin also ameliorated DOX-induced oxidative stress by decreasing lipid peroxidation and upregulating the antioxidant enzymes. Moreover, chrysin attenuated DOX-induced apoptosis via decreasing expression of p53, Bax, Puma, Noxa, cytochrome c and caspase-3 while increasing expression of Bcl-2. DOX induced activation of MAPK; p38 and JNK and increased expression of NF-κB. Meanwhile, DOX suppressed AKT pathway via decreasing expression of its upstream activator VEGF and increasing expression of PTEN. Conversely, chrysin effectively neutralised all these effects. Collectively, these findings indicate that chrysin effectively protected against DOX-induced cardiomyopathy via suppressing oxidative stress, p53-dependent apoptotic pathway, MAPK and NF-κB pathways while augmenting the VEGF/AKT pathway.

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“…The flavone scutellarin shows potential in inhibiting retinal angiogenesis through ROS/HIF-1α/VEGF pathway [27]. Chrysin (Figure 1A) is a flavone-type flavonoid found in honey and herbs and possesses diverse pharmacological activities and multiple biological effects in the central nervous and immune systems [29,30]. Our previous study showed that the multifunctional chrysin exhibited the renoprotection by inhibiting diabetic renal tubulointerstitial fibrosis through blocking epithelial to mesenchymal transition [31].…”

Section: Introductionmentioning

confidence: 99%

Dietary Compound Chrysin Inhibits Retinal Neovascularization with Abnormal Capillaries in db/db Mice

et al. 2016

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Diabetic retinopathy (DR) develops in a significant proportion of patients with chronic diabetes, characterized by retinal macular edema and abnormal retinal vessel outgrowth leading to vision loss. Chrysin, a naturally-occurring flavonoid found in herb and honeycomb, has anti-inflammatory, antioxidant, and anti-cancer properties. This study sought to determine the protective effects of chrysin on retinal neovascularization with abnormal vessels and blood-retinal barrier (BRB) breakdown in 33 mM glucose-exposed human retinal endothelial cells and in db/db mouse eyes. High glucose caused retinal endothelial apoptotic injury, which was inhibited by submicromolar chrysin. This compound diminished the enhanced induction of HIF-1α, vascular endothelial growth factor (VEGF), and VEGF receptor-2 (VEGFR2) in high glucose-exposed retinal endothelial cells. Consistently, oral administration of 10 mg/kg chrysin reduced the induction of these proteins in db/db mouse eye tissues. In addition, chrysin restored the decrement of VE-cadherin and ZO-1 junction proteins and PECAM-1 in hyperglycemia-stimulated retinal endothelial cells and diabetic mouse retina, possibly maintaining tight cell-cell interactions of endothelial cells and pericytes. Anti-apoptotic chrysin reduced the up-regulation of Ang-1, Ang-2, and Tie-2 crucial to retinal capillary occlusion and BRB permeability. Furthermore, orally treating chrysin inhibited acellular capillary formation, neovascularization, and vascular leakage observed in diabetic retinas. These observations demonstrate, for the first time, that chrysin had a capability to encumber diabetes-associated retinal neovascularization with microvascular abnormalities and BRB breakdown.

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Neuroprotective effects of chrysin: From chemistry to medicine

Cited by 165 publications

References 77 publications

Evaluation of Flavonoids as 2019-nCoV Cell Entry Inhibitor Through Molecular Docking and Pharmacological Analysis

Evaluation of Flavonoids as 2019-nCoV Cell Entry Inhibitor Through Molecular Docking and Pharmacological Analysis

Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathways

Dietary Compound Chrysin Inhibits Retinal Neovascularization with Abnormal Capillaries in db/db Mice

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