Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease

Braidy, Nady; Behzad, Sahar; Habtemariam, Solomon; Ahmed, Touqeer; Daglia, Maria; Nabavi, Seyed Mohammad; Sobarzo‐Sánchez, Eduardo

doi:10.2174/1871527316666170328113309

Cited by 126 publications

(87 citation statements)

References 113 publications

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“…Furthermore, nobiletin has been found to have positive effects of nobiletin on propofol-mediated antiinflammatory as well as having neuroprotective effect [4]. It may represent beneficial drug candidates for the treatment and prevention of Alzheimer's and Parkinson's disease because of its naturally occurring phytochemicals [5]. Similar to other flavonoids, NOB exists widely in nature and is found mainly in various citrus peels.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterisation of Nobiletin-Loaded Nanostructured Lipid Carriers

Huang

Dou

et al. 2017

Journal of Nanomaterials

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The objective of this manuscript was to investigate and optimise the potential of nanostructured lipid carriers (NLCs) as a carrier system for nobiletin (NOB), which was prepared by high-pressure homogenisation method. Additionally, this study was focused on the application of NOB-loaded NLC (NOB-NLC) in functional food. Response surface method with a three-level Box-Behnken design was validated through analysis of variance, and the robustness of the design was confirmed through the correspondence between the values measured in the experiments and the predicted ones. Properties of the prepared NOB-NLC, such asaverage, polydispersity, entrapment efficiency, zeta potential, morphology, and crystallinity, were investigated. NOB-NLC exhibited a spherical shape with a diameter of 112.27 ± 5.33 nm, zeta potential of −35.1 ± 2.94 mV, a polydispersity index of 0.251 ± 0.058, and an EE of 81.06% ± 6.02%. Results from X-ray diffraction and differential scanning calorimetry of NOB-NLC reviewed that the NOB crystal might be converted to an amorphous state. Fourier transform infrared spectroscopic analysis demonstrated that chemical interaction was absent between the compound and lipid mixture in NOB-NLC.

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Section: Introductionmentioning

confidence: 99%

Preparation and Characterisation of Nobiletin-Loaded Nanostructured Lipid Carriers

Huang

Dou

et al. 2017

Journal of Nanomaterials

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“…Reducing Aβ1-42 accumulation and levels of APP, inhibiting BACE1 activity (Liu et al, 2017) Curcumin Activating neuronal nitric oxide pathway Caffeic acid Blocking Aβ formation and aggregation (Habtemariam, 2016) Epigallocatechin Modulating the enzymes involved in APP processing and reducing the formation of Aβ (Rezai-Zadeh, 2005) Ferulic acid Exerting antiinflammatory actions (Ghosh et al, 2017) Gallic acid Preventing fibril formation by Aβ peptide (Liu et al, 2013) Genistein Modulating neuroinflammation, Aβ deposition, and tau hyperphosphorylation (Park et al, 2016) Hesperidin Exhibiting high-affinity BACE1 inhibitor, preventing Aβ fibril formation (Chakraborty et al, 2016) Honokiol Modulating excitotoxicity associated with the blockade of glutamate receptors and reducing neuroinflammation (Talarek et al, 2017) Icariin Preventing Aβ1-42 aggregation (Liu et al, 2015) Leucomicin Preventing Aβ1-42 induced oxidative stress (Türkez, 2018) Lycopene Inhibiting NF-κB activity and regulating neuroinflammatory cytokines (Sachdeva and Chopra, 2015) Naringenin Alleviating Aβ-induced impairments, lipid peroxidation, and apoptosis via the estrogenic pathway. (Ghofrani et al, 2015) Nobiletin Reducing Aβ plaques, NFTs, and cognitive impairments (Nakajima et al, 2015) Oleuropein Counteracting amyloid-β peptide and tau aggregation (Martorell et al, 2016) Quercetin Minimizing Aβ1-40 and Aβ1-42 amounts, decreasing BACE1-mediated cleavage of APP (Sabogal-Guáqueta et al, 2015) Rosmarinic acid Preventing Aβ-sheet assembly (Cornejo et al, 2017) Resveratrol Promoting the removal of Aβ peptides and antiinflammatory content (Braidy et al, 2016) Rutin Inhibiting Aβ aggregation, supporting antioxidant SOD, CAT, and GSH-Px enzyme activities (Yu et al, 2015) Sulforaphane Reducing cholinergic neuron loss (Zhang et al, 2014) Tangeretin Alleviating cholinergic deficits, reducing Aβ accumulation, inhibiting tau hyperphosphorylation and increasing NEP levels (Braidy et al, 2017a) Tannic acid…”

Section: Antioxidantmentioning

confidence: 99%

Nonpharmacological treatment options for Alzheimer’s disease: from animal testing to clinical studies

Türkez¹,

Arslan²,

Stefano³

et al. 2020

Turk J Zool

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Despite extensive pharmacological approaches, there is no curative therapy for Alzheimer's disease (AD) or other types of dementias. While current pharmacological options alleviate some symptoms of AD, they can lead to various adverse effects. Hence, nonpharmacological treatment options for AD are often considered with the assumption that they are safe, effective, and economic in managing patients. Furthermore, studies on animal models have suggested that environmental exposures like diet, music, or rewardrelated actions can stimulate neuronal regeneration and differentiation without using any pharmacological factors. The aim of this review is to provide a summary of nonpharmacological treatment options for the management of cognitive, emotional, and behavioral symptoms of AD. In addition, this review provides an overview of the challenging and encouraging experiences and recent studies and problems in cognitive training related to animal models. Nonpharmacological studies of AD are discussed in this literature review in terms of animal models, physical activity, brain stimulation, and the role of social communication.

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“…Nobiletin and tangeretin are two major PMFs that are particularly abundant in citrus peels (Choi et al, 2007;Inafuku-Teramoto et al, 2011;Nogata et al, 2006). Recently, citrus PMFs have attracted great interest due to their protective effects against memory impairment in Alzheimer's disease (Braidy et al, 2017;Kimura et al, 2018;Onozuka et al, 2008), as well as their anti-tumor, anti-hyperglycemia, antiobesity, and anti-neuroinflammation and insulin resistance activities (Ho and Kuo, 2014;Kawaii et al, 1999;Lee et al, 2010Lee et al, , 2013Minagawa et al, 2001;Miyata et al, 2008;Onda et al, 2013;Surichan et al, 2018;Wang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Accumulation of Polymethoxyflavones and <i>O</i>-methyltransferase Gene Expression in Various Citrus Cultivars

et al. 2020

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Polymethoxyflavones (PMFs) are naturally occurring O-methylated flavones predominantly accumulated in different citrus tissues that show numerous human-health promoting activities. O-methyltransferase (OMT) family members are involved in the biosynthesis of PMFs in plant species including citrus. Although the distribution of PMFs has been determined in citrus cultivars, the relation between the accumulation of PMFs and the related OMT gene expression in leaves and flavedos (exocarps) of citrus cultivars remains to be clarified. In this study, we investigated the accumulation of nobiletin and tangeretin in the leaves and flavedos of various citrus cultivars widely grown in Japan. As expected, the accumulation of nobiletin and tangeretin varied among the citrus cultivars and the two tissues, and nobiletin and tangeretin accumulated at higher levels in flavedos than in leaves. In particular, we clearly demonstrated that the nobiletin content showed a significant and positive correlation (r = 0.824, P = 0.00182) between leaves and flavedos. Based on these results, the concentration of PMFs in leaves could be utilized as an early selection marker for seedlings in the juvenile phase that are expected to accumulate a higher amount of PMFs in fruit, resulting in a shortening of the breeding period. We also identified two novel candidate genes, CreOMT1 and CreOMT4, putatively involved in PMF biosynthesis in citrus. Notably, the expression of CreOMT1 showed a significant correlation (r = 0.700, P = 0.0243) with the nobiletin content in the flavedos of 10 citrus cultivars. Our results provide valuable information for developing new citrus cultivars that could accumulate higher PMFs and insight into elucidating the PMF biosynthetic pathway in citrus in the future.

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Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease

Cited by 126 publications

References 113 publications

Preparation and Characterisation of Nobiletin-Loaded Nanostructured Lipid Carriers

Preparation and Characterisation of Nobiletin-Loaded Nanostructured Lipid Carriers

Nonpharmacological treatment options for Alzheimer’s disease: from animal testing to clinical studies

Accumulation of Polymethoxyflavones and <i>O</i>-methyltransferase Gene Expression in Various Citrus Cultivars

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