Neuroprotective effects of curcumin against acetamiprid-induced neurotoxicity and oxidative stress in the developing male rat cerebellum: biochemical, histological, and behavioral changes

Abstract

Curcumin is a molecule found in turmeric root that has anti-inflammatory, antioxidant, and anti-tumor properties and has been widely used as both an herbal drug and a food additive to treat or prevent neurodegenerative diseases. This study aimed to investigate the effect of curcumin on neurobehavioral and neuropathological alterations induced by acetamiprid on male rats. Three groups of ten male Wistar rats each were used for the study: the first was a control group (CTR) that did not consume acetamiprid (ACE); the second was an experimental group (ACE) that consumed 40 mg/kg body weight/day of acetamiprid; and the third group (CUR) received curcumin (100 mg/kg) and acetamiprid (40 mg/kg) in combination. Neurobehavioral evaluations including inclined plane performance and forepaw grip time were studied. Treatment with CUR significantly prevented ACE-treated rats from impairments in the performance of neurobehavioral tests, indicating the presence of deficits on sensorimotor and neuromuscular responses. In addition, Curcumin administration protects rats against acetamiprid-induced cerebellum toxicity such as increase in AChE and BChE activities, decrease on cells viability, oxidative stress, and an increase of intracellular calcium. Taken together, these results demonstrate for the first time that ACE treatment substantially impairs the survival of primary neuronal cells through the induction of necrosis concomitantly with the generation of an oxidative stress. Additionally, curcumin reduced histopathological changes caused by ACE.

Involvement of the serotonergic system and neuroplasticity in the antidepressant effect of curcumin in ovariectomized rats: Comparison with oestradiol and fluoxetine

“…CUR as a phytonutrient was documented to have antidepressant activity on experimental animals and patient with depression status (Behr et al, ; Ng et al, ; Xu et al, ). Based on several studies used various doses of CUR to address its neuroprotective impact, a dose of 100 mg kg − 1 of CUR was documented to have antidepressant activity in primary studies (Da Silva Morrone et al, ; Dhouib et al, ; Sanmukhani et al, ). The current results revealed that CUR improved the depressive‐like behaviour relative to E 2 , suggesting the antidepressant effect of CUR.…”

Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer’s Disease

“…Molecules derived from plant extracts are currently considered as potential complementary and/or alternative therapies against AD. Indeed, the use of antioxidant agents from diet showed a significant therapeutic effect on various neurodegenerative disorders associated with oxidative stress [ 15 ]. Curcumin (CUR), a major compound of curcuma, was extensively studied for its antioxidant, anticancer, anti-inflammatory and cytoprotective properties [ 15 , 16 , 17 ].…”

“…Indeed, the use of antioxidant agents from diet showed a significant therapeutic effect on various neurodegenerative disorders associated with oxidative stress [ 15 ]. Curcumin (CUR), a major compound of curcuma, was extensively studied for its antioxidant, anticancer, anti-inflammatory and cytoprotective properties [ 15 , 16 , 17 ]. Particularly, CUR was shown to provide neuroprotection by inducing the upregulation of the transcription of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and by suppression of NF-κB activation in cellular and animal models of neurodegenerative disorders [ 18 , 19 ].…”

Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice

“…However, recent studies have reported reproductive toxicity in quails (Tokumoto et al, 2013;Hoshi et al, 2014) and adverse neurobehavioral effects in mice and rats (Hirano et al, 2015Dhouib et al, 2017;Takada et al, 2018;Yoneda et al, 2018). In addition, it has been shown that exposure of perinatal mice to NNs causes abnormalities in germ cells (Yanai et al, 2017) and induction of anxiety-like behaviors (Tanaka , 2012;Sano et al, 2016) in their offspring.…”