Neuroprotective effects of ethanolic extract from dry Rhodiola rosea L. rhizomes

Kim, Kwan Joong; Jung, Young Sung; You, Dong Min; Lee, Seung Hyun; Lee, Guemsan; Kwon, Kang Beom; Kim, Dae‐Ok

doi:10.1007/s10068-020-00868-7

Cited by 15 publications

(9 citation statements)

References 31 publications

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“…Indeed, an ethanolic RRE containing high concentrations of phenolic compounds, particularly salidroside, showed a strong antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl scavenging capacity assay (DPPH), in the 2,2'-azino-bis(3-ethylbenzothiazoline-6- 13 Oxidative Medicine and Cellular Longevity sulphonic acid) scavenging capacity assay (ABTS), and in the ferric reducing antioxidant power assay (FRAP) [55]. In line, a very recent study showed that Rhodiola rosea rhizomes, especially the two bioactive compounds salidroside and tyrosol, showed free radical scavenging activity when assessed in the ABTS and DPPH assays, while it also normalized dihydrochloride-induced increase of ROS in PC12 cells [59]. Additionally, salidroside protected PC12 cells from H 2 O 2induced apoptosis through inactivation of the caspase cascade and through prevention of cytochrome c release [53].…”

Section: Discussionmentioning

confidence: 88%

Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic Response Curve Manner via Elimination of ROS and Induction of Neurite Outgrowth

Agapouda

Grimm

Lejri

2022

Oxidative Medicine and Cellular Longevity

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Background. Sustained stress with the overproduction of corticosteroids has been shown to increase reactive oxygen species (ROS) leading to an oxidative stress state. Mitochondria are the main generators of ROS and are directly and detrimentally affected by their overproduction. Neurons depend almost solely on ATP produced by mitochondria in order to satisfy their energy needs and to form synapses, while stress has been proven to alter synaptic plasticity. Emerging evidence underpins that Rhodiola rosea, an adaptogenic plant rich in polyphenols, exerts antioxidant, antistress, and neuroprotective effects. Methods. In this study, the effect of Rhodiola rosea extract (RRE) WS®1375 on neuronal ROS regulation, bioenergetics, and neurite outgrowth, as well as its potential modulatory effect on the brain derived neurotrophic factor (BDNF) pathway, was evaluated in the human neuroblastoma SH-SY5Y and the murine hippocampal HT22 cell lines. Stress was induced using the corticosteroid dexamethasone. Results. RRE increased bioenergetics as well as cell viability and scavenged ROS with a similar efficacy in both cells lines and counteracted the respective corticosteroid-induced dysregulation. The effect of RRE, both under dexamethasone-stress and under normal conditions, resulted in biphasic U-shape and inverted U-shape dose response curves, a characteristic feature of adaptogenic plant extracts. Additionally, RRE treatment promoted neurite outgrowth and induced an increase in BDNF levels. Conclusion. These findings indicate that RRE may constitute a candidate for the prevention of stress-induced pathophysiological processes as well as oxidative stress. Therefore, it could be employed against stress-associated mental disorders potentially leading to the development of a condition-specific supplementation.

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Section: Discussionmentioning

confidence: 88%

Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic Response Curve Manner via Elimination of ROS and Induction of Neurite Outgrowth

Agapouda

Grimm

Lejri

2022

Oxidative Medicine and Cellular Longevity

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“…Thus, safer and more e cacious compounds for treating depression are urgently needed. Salidroside, as a bioactive compound, is safe and has been developed as a novel drug for the prevention and treatment of mood disorders such as depression and anxiety (54,(63)(64)(65)(66)(67). Herein, the mechanisms underlying the effects of salidroside are discussed and analysed to explore the potential of this agent in alleviating mental disorders and related sequelae.…”

Section: Effects Of Salidroside On Depression and Anxietymentioning

confidence: 99%

“…Salidroside, a natural phenolic compound, is one of the main active ingredients of the rhizomes of Rhodiola (50)(51)(52)(53)(54)(55). Recent studies have shown that salidroside has various pharmacological activities, including anti-in ammatory, antioxidant, anticancer, antimetabolic, and neuroprotective activities (56-58), demonstrating its great potential for preventing mental health disorders and improving mental health in humans.…”

Section: Introductionmentioning

confidence: 99%

Brain Network Homeostasis and Plasticity of Salidroside for Achieving Neuroprotection and Treating Psychiatric Sequelae Stemming from Stress

Zhu

Liu

Gao

et al. 2023

Preprint

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The coronavirus disease 2019 (COVID-19) pandemic has affected the mental health of individuals worldwide, and the risk of psychiatric sequelae and consequent mental disorders has increased among the general population, health care workers and patients with COVID-19. Achieving effective and widespread prevention of pandemic-related psychiatric sequelae to protect the mental health of the global population is a serious challenge. Salidroside, as a natural agent, has substantial pharmacological activity and health effects, exerts obvious neuroprotective effects, and may be effective in preventing and treating psychiatric sequelae and mental disorders resulting from stress stemming from the COVID-19 pandemic. Herein, we systematically summarise, analyse and discuss the therapeutic effects of salidroside in the prevention and treatment of psychiatric sequelae as well as its roles in preventing the progression of mental disorders, and fully clarify the potential of salidroside as a widely applicable agent for preventing mental disorders caused by stress; the mechanisms underlying the potential protective effects of salidroside are involved in the regulation of the oxidative stress, neuroinflammation, neural regeneration and cell apoptosis in the brain, the network homeostasis of neurotransmission, HPA axis and cholinergic system, and the improvement of synaptic plasticity. Notably, this review innovatively proposes that salidroside is a potential agent for treating stress-induced health issues during the COVID-19 pandemic and provides scientific evidence and a theoretical basis for the use of natural products to combat the current mental health crisis.

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“…Phenylpropane derivatives mediate the adaptogenic action of R. Rosea preparations (e.g., rosavin) and phenylethylene derivatives (e.g., tyrosol and salidroside), which have pleiotropic pharmacological effects on the neuroendocrine and immune systems ( Panossian et al, 2021 ). The rhizome of R. Rosea L. (and the chemicals isolated from it) have been shown to protect neuronal PC-12 cells from oxidative stress and demonstrate mild acetylcholinesterase inhibition, respectively ( Kim K. J. et al, 2021 ). Several clinical studies have demonstrated that using the R. Rosea extract SHR-5 regularly has an anti-fatigue effect and promotes cognitive function while decreasing “burnout” in individuals with chronic fatigue syndrome.…”

Section: Aromatic Plants and Extracts For Mood Disordersmentioning

confidence: 99%

Inhalation Aromatherapy via Brain-Targeted Nasal Delivery: Natural Volatiles or Essential Oils on Mood Disorders

Cui

Wei

et al. 2022

Front. Pharmacol.

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Mood disorders, also often referred to as affective disorders, are a group of psychiatric illnesses that severely impact mood and its related functions. The high medical expenditures have placed a significant financial burden on patients and their families. Aromatherapy is an alternative and complementary treatment that utilizes essential oils (EOs) or volatile oils (VOs) to achieve major therapeutic goals. In general, EOs are volatile chemicals that enter the body primarily through skin absorption and/or nasal inhalation. In addition, they can work through oral administration. Inhalation aromatherapy has shown unique advantages for treating mood disorders, especially depression, anxiety and mental disorders such as sleep disorder, which have been validated over the last decade through clinical and animal studies. Accumulating evidence has shown that EOs or VOs can bypass the blood-brain barrier to target brain tissue through the nasal-brain pathway. Subsequently, they act on the cerebral cortex, thalamus, and limbic system in the brain to improve symptoms of anxiety, depression and improve sleep quality. Here, we review the natural aromatic plants’ volatiles or essential oils used commonly as adjuncts to manage mood disorders and illustrate the mechanisms of inhalation aromatherapy, and mainly summarized the application of transnasal inhalation aromatherapy in depression, anxiety, and sleep disorders. We conclude that aromatherapy does not cause side-effects, which is vastly different from commonly used psychotropic drugs. Inhalation aromatherapy via brain-targeted nasal delivery offers potentially efficacious treatment for mental disorders and merits further study.

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Neuroprotective effects of ethanolic extract from dry Rhodiola rosea L. rhizomes

Cited by 15 publications

References 31 publications

Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic Response Curve Manner via Elimination of ROS and Induction of Neurite Outgrowth

Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic Response Curve Manner via Elimination of ROS and Induction of Neurite Outgrowth

Brain Network Homeostasis and Plasticity of Salidroside for Achieving Neuroprotection and Treating Psychiatric Sequelae Stemming from Stress

Inhalation Aromatherapy via Brain-Targeted Nasal Delivery: Natural Volatiles or Essential Oils on Mood Disorders

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