Neuroprotective Effects of Extract of Panax ginseng Sprouts Cultivated by Hydroponics Using Desalinated Magma Seawater of Jeju Island (Korea) Against Neurotoxicity In Vitro

최윤표,; 장윤비,; 최지선,; 권미향,; 이다연,; 강병우,; 이진설,; 서보승,; 김대원,; 정재준,; 이지윤,; 장원국,; 강승우,

doi:10.3746/jkfn.2020.49.9.925

Cited by 2 publications

(3 citation statements)

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“…In addition, ThinkGIN™ had no side effects. In a previous study conducted with hydroponic ginseng sprout extract [ 61 ], AChE activity was decreased by ginseng sprout extract, suggesting that it could improve memory by increasing ACh, a neurotransmitter important for regulating synaptic plasticity. A previous study [ 62 ] has also shown that ginseng extract can increase ACh synthesis and inhibit ACh degradation, which can significantly increase synaptic ACh levels and improve scopolamine-induced amnesia.…”

Section: Discussionmentioning

confidence: 99%

“…Preclinical studies have suggested that ginseng sprouts can improve memory [ 17 , 31 , 61 ]. In a scopolamine-induced memory deficit mouse model [ 17 ], ThinkGIN™ regulated synaptic plasticity by activating the signaling pathway of AKT/ERK/CREB and reduced cortical inflammation by inhibiting COX-2, NLRP3, and Iba-1, thereby improving the memory deficit behavior.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that ginsenosides can improve memory by improving neuroinflammation [ 17 ]. In vitro studies [ 61 ] of hydroponic sprout ginseng extract have shown that it can inhibit neurotoxicity (caspase-3, PPAR, Bax, Bcl-2), decrease neuroinflammatory responses (MAPK, NF-κB p65, and COX-2), and regulate synaptic plasticity. It also showed an effect of improving memory through CREB activation (BDNF) and neurotransmitter regulation (AChE).…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Baek,

Ha,

Park

et al. 2024

Nutrients

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Sprout ginseng extract (ThinkGIN™) manufactured through a smart farm system has been shown to improve memory in preclinical studies. This study conducted a 12-week randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of ThinkGIN™ for improving memory in subjective memory impairment (SMI). Subjects aged 55 to 75 years with SMI participated in this study. A total of 80 subjects who met the inclusion/exclusion criteria were assigned to the ThinkGIN™ group (n = 40, 450 mg ThinkGIN™/day) or a placebo group (n = 40). Efficacy and safety evaluations were conducted before intervention and at 12 weeks after intervention. As a result of 12 weeks of ThinkGIN™ intake, significant differences in SVLT, RCFT, MoCA-K, PSQI-K, and AChE were observed between the two groups. Safety evaluation (AEs, laboratory tests, vital signs, and electrocardiogram) revealed that ThinkGIN™ was safe with no clinically significant changes. Therefore, ThinkGIN™ has the potential to be used as a functional food to improve memory.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Baek,

Ha,

Park

et al. 2024

Nutrients

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Antioxidant efficacy of Jeju crop extracts using Jeju lava seawater as a solvent

et al. 2022

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Jeju lava seawater's abundant minerals are known to exert antioxidant effects that remove the free radicals responsible for aging. Therefore, lava seawater reportedly possesses high commercial value as a functional food material. This study compared and analyzed the antioxidant activities of extracts from crops produced in Jeju (carrots, blueberries, and mandarins) using distilled water and lava seawater as solvents. Lava seawater extracts exhibited higher total polyphenol and flavonoid contents of blueberries and mandarins than distilled water extracts. Furthermore, the antioxidant enzymatic and 2, 2-diphenyl-1picrylhydrazyl radical-scavenging activities of these crops were higher in lava seawater extracts than in distilled water extracts. In particular, using Vero cells, the ROS-scavenging efficacies of blueberries and mandarins were found to be higher in lava seawater extracts. Meanwhile, the antioxidant activities of carrots were higher in lava seawater extracts, despite no difference in total polyphenol and flavonoid contents. These results suggest that lava seawater exhibits favorable potential as a solvent in the functional food industry, and lava seawater-based Jeju crop extracts are potentially useful as functional food ingredients.

show abstract

Neuroprotective Effects of Extract of Panax ginseng Sprouts Cultivated by Hydroponics Using Desalinated Magma Seawater of Jeju Island (Korea) Against Neurotoxicity In Vitro

Cited by 2 publications

References 0 publications

Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Antioxidant efficacy of Jeju crop extracts using Jeju lava seawater as a solvent

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