2000
DOI: 10.1089/neu.2000.17.19
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Neuroprotective Effects of Gacyclidine After Experimental Photochemical Spinal Cord Lesion in Adult Rats: Dose-Window and Time-Window Effects

Abstract: The aim of this study was to evaluate the efficacy, optimal dose, and optimal time-window of gacyclidine, a novel N-methyl-D-aspartate (NMDA) receptor antagonist, in terms of its functional, histopathological, and electrophysiological effects after experimental spinal cord injury. The spinal cord of rats was damaged by a photochemical method and the animals were treated by saline or gacyclidine at doses of 1, 2.5, or 5 mg/kg 10 min after injury or gacyclidine 1 mg/kg 10, 30, 60, and 120 min after injury. The t… Show more

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Cited by 45 publications
(35 citation statements)
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“…* /1/w p , 0.05; ** /11/w w p , 0.01; *** /111 /w w w p , 0.001. (Gaviria et al, 2000b;Pencalet et al, 1993) and 5 min in Watson's studies (Prado et al, 1987), was most inadequate in mice, which constrained us to apply significantly longer irradiation times.…”
Section: Discussionmentioning
confidence: 99%
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“…* /1/w p , 0.05; ** /11/w w p , 0.01; *** /111 /w w w p , 0.001. (Gaviria et al, 2000b;Pencalet et al, 1993) and 5 min in Watson's studies (Prado et al, 1987), was most inadequate in mice, which constrained us to apply significantly longer irradiation times.…”
Section: Discussionmentioning
confidence: 99%
“…Since ischemia represents one of the main aspects of traumatic SCI, the infarct model developed by Watson in rats (Cameron et al, 1990;Prado et al, 1987;Watson et al, 1986) has been extremely useful in investigating this component of traumatic SCI (Bunge et al, 1994;Gaviria et al, 2000b;Olby and Blakemore, 1996;Pencalet et al, 1993;Sampath et al, 1995;Van Reempts and Borgers, 1994). Our results demonstrate that a consistent progression of behavioral and histopathological abnormalities could be established, reproducing experimentally controlled, graded ischemic SCI in mice.…”
Section: Discussionmentioning
confidence: 99%
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“…For instance, Vitamin C and E are strong antioxidant, which can provide best protection against cord ischemia [18][19][20]. A novel N-methyl-D-aspartate (NMDA) antagonist, Gacyclidine, owns its capacity for reducing the extent of an ischemic lesion and may promise its future use [21,22]. If medical managements don't reveal significant improvement of delayed neurologic compromise, surgery that return spinal cord to its former kyphotic position by releasing part of the correction may be considered [4,23].…”
Section: Disscussionmentioning
confidence: 99%