Neuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in rats

Gökçe, Emre Cemal; Kahveci, Ramazan; Atanur, Osman Malik; Gürer, Bora; Aksoy, Nurkan; Gökçe, Aysun; Sargon, Mustafa F.; Cemil, Berker; Erdoğan, Bülent; Kahveci, Ozan

doi:10.1016/j.injury.2015.08.017

Cited by 41 publications

(20 citation statements)

References 52 publications

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“…The (R)-ATester of 12b was synthesized by the same method and obtained from HPLC chromatograph (3.71 mg, t R 17.5 min). Data of 12b: white powder 1. H-NMR (CDCl 3 500 MHz, selected signals): 1.22 (s, Me(18)); 1.25 (s, Me (19)); 0.74 (d, J = 6.0, Me(21)); 0.93 (s, Me(29)); 1.10 (d, J = 7.0, Me(27)).…”

mentioning

confidence: 99%

Triterpenes and Meroterpenes with Neuroprotective Effects from Ganoderma leucocontextum

Chen

Zhang

Ren

et al. 2018

Chemistry & Biodiversity

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Ganoderma leucocontextum is a well-known medicinal mushroom cultivated in the Tibet Plateau of China. Chemistry investigation on the fruiting bodies of this mushroom resulted in the isolation of sixteen secondary metabolites including three new lanostane triterpenes, ganoleucoins Q - S (1 - 3), as well as thirteen known compounds (4 - 16). The structures of compounds 1 - 3 were determined by NMR, MS, CD spectral analysis, and chemical derivation method. The neuroprotective effects of compounds 1 - 16 were tested on PC12 cells. Compounds 1 and 2 showed protective effects against the H O induced damage with the survival rate of 83.19 ± 0.92%, 73.37 ± 1.25% at the concentration of 200 μm, respectively. Meanwhile, compounds 1 and 2 induced neurite outgrowth at 50 - 200 μm. The results from this study suggested that G. leucocontextum and its metabolites may be potential functional food ingredients for the prevention of neurodegenerative diseases.

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mentioning

confidence: 99%

Triterpenes and Meroterpenes with Neuroprotective Effects from Ganoderma leucocontextum

Chen

Zhang

Ren

et al. 2018

Chemistry & Biodiversity

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“…Recent studies especially report the therapeutic effects of the mushroom on cancer, asthma, allergies, autoimmune diseases, neurological diseases, diabetes, hypertension, obesity, liver diseases, and many other conditions ( Figure 2). [36][37][38][39][40][41][42][43][44] anTIcancer eFFecT…”

Section: Health Effectmentioning

confidence: 99%

“…GL-PS reduced expressions of pro-inflammatory and cytotoxic factors from microglia and efficiently protected dopaminergic neurons against inflammation. 40 Moreover, Zhang et al suggested that G. lucidum spores protect injured spinal motor neurons by up-or down-regulating the expression levels of the proteins that play an important role in axon degeneration. 78 Such results show the nerve protection and antioxidant characteristics of G. lucidum extracts.…”

Section: Rats Exposed To 4-gy or 8-gy Radiation Dosementioning

confidence: 99%

“…Treatment with both GL-PS and MP inhibited lipid peroxidation and significantly lowered MDA levels (Trauma group: 5.68±0.58 nmol/mg-protein; MP group: 2.22±0.21 nmol/mg-protein; GL-PS group: 2.05±0.27 nmol/mg-protein). 40 Matsuzaki et al found in their study performed on rats that G. lucidum mycelium (MAC) has an antidepressant-like potential and anxiety reducing-like effects on memory-associated and/or stress-induced anxiety because of the antagonism of serotonin precursor 5-hydroxytryptamine receptor 2A receptors. 79 Another study performed on rats found an increase on neural progenitor cell (NPC) proliferation by oral administration of GL-PS to increase neurogenesis and to relieve cognitive disorders in the rats with transgenic Alzheimer's disease.…”

Section: Rats Exposed To 4-gy or 8-gy Radiation Dosementioning

confidence: 99%

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Connection of Ganoderma Lucidum with Health

Zengin¹,

Şanlıer²

2020

J Tradit Complem Med

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“…In the last two years, many research studies, focusing on the identification of drugs potentially effective in SCI treatment, have been published [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 ,…”

Section: Overview Of Current Pharmacological Approaches For the Trmentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems to Bridge Spinal Cord Injury

et al. 2017

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The complex pathophysiology of spinal cord injury (SCI) may explain the current lack of an effective therapeutic approach for the regeneration of damaged neuronal cells and the recovery of motor functions. A primary mechanical injury in the spinal cord triggers a cascade of secondary events, which are involved in SCI instauration and progression. The aim of the present review is to provide an overview of the therapeutic neuro-protective and neuro-regenerative approaches, which involve the use of nanofibers as local drug delivery systems. Drugs released by nanofibers aim at preventing the cascade of secondary damage (neuro-protection), whereas nanofibrous structures are intended to re-establish neuronal connectivity through axonal sprouting (neuro-regeneration) promotion, in order to achieve a rapid functional recovery of spinal cord.

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Neuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in rats

Cited by 41 publications

References 52 publications

Triterpenes and Meroterpenes with Neuroprotective Effects from Ganoderma leucocontextum

Triterpenes and Meroterpenes with Neuroprotective Effects from Ganoderma leucocontextum

Connection of Ganoderma Lucidum with Health

Nanofiber Scaffolds as Drug Delivery Systems to Bridge Spinal Cord Injury

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