Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease

Liu, Li Xing; Chen, Wen Fang; Xie, Jun; Wong, Man Sau

doi:10.1016/j.neures.2007.10.005

Cited by 117 publications

(68 citation statements)

References 32 publications

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“…Thus, low amounts of phytoestrogens can protect against various cancers such as prostate, breast, bowel, and other cancers (Adlercreutz, 2002;Zhao and Mu, 2011). Moreover, soy isoflavones, including genistein and daidzein, can protect neurons in animal models of ALS, stroke, chronic sciatic nerve injury, and PD (Trieu and Uckun, 1999;Liu et al, 2008;Valsecchi et al, 2008;Chinta et al, 2013). Interestingly, findings suggest that soy isoflavones can improve cognitive function in postmenopausal women (Kritz-Silverstein et al, 2003).…”

Section: B Environmental Toxicantsmentioning

confidence: 99%

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

et al. 2014

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Section: B Environmental Toxicantsmentioning

confidence: 99%

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

et al. 2014

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“…Significant improvements in short-term and long-term memory have also been observed in human subjects eating a high-soy diet for 10 weeks (File et al, 2001). In addition, genistein has been found to have a neuroprotective effect on cortical cell lines (Sonee, Sum, Wang, & Mukherjee, 2004), on dopaminergic neurons in a mouse model of Parkinson's disease (Liu, Chen, Xie, & Wong, 2008), and in a 6-hydroxydopamine hemiparkinsonian rat model (Baluchnejadmojarad, Roghani, Nadoushan, & Bagheri, 2009). Estrogen also has a neuroprotective effect, as shown by several in vivo and in vitro experiments.…”

Section: Introductionmentioning

confidence: 99%

Genistein ameliorates learning and memory deficits in amyloid β(1–40) rat model of Alzheimer’s disease

Bagheri

Joghataei

Mohseni

et al. 2011

Neurobiology of Learning and Memory

210

112

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Genistein ameliorates learning and memory deficits in amyloid beta ((1-40) AbstractAlzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by increased β-amyloid (Aβ) deposition and neuronal dysfunction leading to impaired learning and recall.Ageing, heredity, and induced oxidative stress are among proposed risk factors. The increased frequency of the disease in women also suggests a role for estrogen in development of AD. In the present study, effects of the phytoestrogen genistein (10 mg/kg) on learning and memory impairments was assessed in intrahippocampal A (1-40) -injected rats. The estrogen receptor antagonist fulvestrant was injected intracerebroventricularly in a group of A-lesioned rats. The A-injected animals exhibited the following: lower spontaneous alternation score in Y-maze tasks, impaired retention and recall capability in the passive avoidance test, and fewer correct choices and more errors in the RAM task. Genistein, but not genistein and fulvestrant, significantly improved most of these parameters. Measurements of oxidative stress markers in hippocampal tissue of A-injected rats showed an elevation of malondialdehyde (MDA) and nitrite content, and a reduction of superoxide dismutase (SOD) activity. Genistein significantly attenuated the increased MDA content but did not affect the nitrite content or SOD activity.These results indicate that genistein pretreatment ameliorates Aβ-induced impairment of shortterm spatial memory in rats through an estrogenic pathway and by inducing attenuation of oxidative stress.

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“…Soy isoflavones have been reported to interact with estrogen receptors, particularly in the nervous system through inhibition of tyrosine kinases. 22 Additional trials evaluating soy consumption on QoL in men may be warranted since findings from this trial and from Sharma et al 9 are mixed.…”

Section: Hot Flash Symtpom Severitymentioning

confidence: 88%

Randomized Trial to Assess the Impact of Venlafaxine and Soy Protein on Hot Flashes and Quality of Life in Men With Prostate Cancer

Vitolins

Griffin

Tomlinson

et al. 2013

JCO

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A B S T R A C T PurposeHot flashes occur in approximately 80% of androgen-deprived men. Few intervention studies have been conducted to relieve hot flashes in men. Patients and MethodsEligible androgen-deprived men were randomly assigned to one of four daily regimens (2 ϫ 2 factorial design) for 12 weeks: milk protein powder and placebo pill, venlafaxine and milk protein powder, soy protein powder and placebo pill, or venlafaxine and soy protein powder. The primary end point was hot flash symptom severity score (HFSSS), defined as number of hot flashes times severity. The secondary end point was quality of life (QoL), assessed by using the Functional Assessment of Cancer Therapy-Prostate. ResultsIn all, 120 men age 46 to 91 years participated. Most were white (78%) and overweight or obese (83%). Toxicity was minimal. Neither venlafaxine nor soy protein alone or in combination had a significant effect on HFSSS. Soy protein, but not venlafaxine, improved measures of QoL. ConclusionIn androgen-deprived men, neither venlafaxine nor soy proved effective in reducing hot flashes. Interventions that appear effective for decreasing hot flashes in women may not always turn out to be effective in men.

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Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease

Cited by 117 publications

References 32 publications

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

Genistein ameliorates learning and memory deficits in amyloid β(1–40) rat model of Alzheimer’s disease

Randomized Trial to Assess the Impact of Venlafaxine and Soy Protein on Hot Flashes and Quality of Life in Men With Prostate Cancer

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